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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Addressing Decontaminated Respirators: Some Methods Appear To Damage Mask Integrity And Protective Function, Richard E. Peltier, Jiayuan Wang, Brian L. Hollenbeck, Jennifer Lanza, Ryan M. Furtado, Jay Cyr, Richard T. Ellison, Kimiyoshi J. Kobayashi
Addressing Decontaminated Respirators: Some Methods Appear To Damage Mask Integrity And Protective Function, Richard E. Peltier, Jiayuan Wang, Brian L. Hollenbeck, Jennifer Lanza, Ryan M. Furtado, Jay Cyr, Richard T. Ellison, Kimiyoshi J. Kobayashi
Environmental Health Sciences Faculty Publication Series
Decontamination of N95 respirators is being used by clinicians in the face of a global shortage of these devices. Some treatments for decontamination, such as some vaporized hydrogen peroxide methods or ultraviolet methods, had no impact on respiratory performance, while other treatments resulted in substantial damage to masks.
Aging Induces Profound Changes In Sncrna In Rat Sperm And These Changes Are Modified By Perinatal Exposure To Environmental Flame Retardant, Alexander Suvorov, J. Richard Pilsner, Vladimir Naumov, Victoria Shtratnikova, Anna Zheludkevich, Evgeny Gerasimov, Maria Logachev, Oleg Sergeyev
Aging Induces Profound Changes In Sncrna In Rat Sperm And These Changes Are Modified By Perinatal Exposure To Environmental Flame Retardant, Alexander Suvorov, J. Richard Pilsner, Vladimir Naumov, Victoria Shtratnikova, Anna Zheludkevich, Evgeny Gerasimov, Maria Logachev, Oleg Sergeyev
Environmental Health Sciences Faculty Publication Series
Advanced paternal age at fertilization is a risk factor for multiple disorders in offspring and may be linked to age-related epigenetic changes in the father’s sperm. An understanding of aging-related epigenetic changes in sperm and environmental factors that modify such changes is needed. Here, we characterize changes in sperm small non-coding RNA (sncRNA) between young pubertal and mature rats. We also analyze the modification of these changes by exposure to environmental xenobiotic 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47). sncRNA libraries prepared from epididymal spermatozoa were sequenced and analyzed using DESeq 2. The distribution of small RNA fractions changed with age, with fractions mapping …
Hormesis And Ginseng: Ginseng Mixtures And Individual Constituents Commonly Display Hormesis Dose Responses, Especially For Neuroprotective Effects, Edward Calabrese Ph.D.
Hormesis And Ginseng: Ginseng Mixtures And Individual Constituents Commonly Display Hormesis Dose Responses, Especially For Neuroprotective Effects, Edward Calabrese Ph.D.
Environmental Health Sciences Faculty Publication Series
This paper demonstrates that ginseng mixtures and individual ginseng chemical constituents commonly induce hormetic dose responses in numerous biological models for endpoints of biomedical and clinical relevance, typically providing a mechanistic framework. The principal focus of ginseng hormesis-related research has been directed toward enhancing neuroprotection against conditions such as Alzheimer’s and Parkinson’s Diseases, stroke damage, as well as enhancing spinal cord and peripheral neuronal damage repair and reducing pain. Ginseng was also shown to reduce symptoms of diabetes, prevent cardiovascular system damage, protect the kidney from toxicities due to immune suppressant drugs, and prevent corneal damage, amongst other examples. These …
Healthspan Enhancement By Olive Polyphenols In C. Elegans Wild Type And Parkinson’S Models, Gabriele Di Rosa, Givovanni Brunetti, Maria Scuto, Angela Trovato Salinaro, Edward Calabrese Ph.D., Roberto Crea, Christian Schmitz-Linneweber, Vittorio Calabrese, Nadine Saul
Healthspan Enhancement By Olive Polyphenols In C. Elegans Wild Type And Parkinson’S Models, Gabriele Di Rosa, Givovanni Brunetti, Maria Scuto, Angela Trovato Salinaro, Edward Calabrese Ph.D., Roberto Crea, Christian Schmitz-Linneweber, Vittorio Calabrese, Nadine Saul
Environmental Health Sciences Faculty Publication Series
Parkinson’s disease (PD) is the second most prevalent late-age onset neurodegenerative disorder, affecting 1% of the population after the age of about 60 years old and 4% of those over 80 years old, causing motor impairments and cognitive dysfunction. Increasing evidence indicates that Mediterranean diet (MD) exerts beneficial effects in maintaining health, especially during ageing and by the prevention of neurodegenerative disorders. In this regard, olive oil and its biophenolic constituents like hydroxytyrosol (HT) have received growing attention in the past years. Thus, in the current study we test the health-promoting effects of two hydroxytyrosol preparations, pure HT and Hidrox …
Hydrogen Sulfide And Carnosine: Modulation Of Oxidative Stress And Inflammation In Kidney And Brain Axis, Vittorio Calabrese, Maria Scuto, Angela Trovato Salinao, Giuseppe Dionisio, Sergio Modafferi, Maria Laura Ontario, Valentina Greco, Sebastiano Sciuto, Claus Peter Schmitt, Edward Calabrese Ph.D., Verena Peters
Hydrogen Sulfide And Carnosine: Modulation Of Oxidative Stress And Inflammation In Kidney And Brain Axis, Vittorio Calabrese, Maria Scuto, Angela Trovato Salinao, Giuseppe Dionisio, Sergio Modafferi, Maria Laura Ontario, Valentina Greco, Sebastiano Sciuto, Claus Peter Schmitt, Edward Calabrese Ph.D., Verena Peters
Environmental Health Sciences Faculty Publication Series
Emerging evidence indicates that the dysregulation of cellular redox homeostasis and chronic inflammatory processes are implicated in the pathogenesis of kidney and brain disorders. In this light, endogenous dipeptide carnosine (β-alanyl-L-histidine) and hydrogen sulfide (H2S) exert cytoprotective actions through the modulation of redox-dependent resilience pathways during oxidative stress and inflammation. Several recent studies have elucidated a functional crosstalk occurring between kidney and the brain. The pathophysiological link of this crosstalk is represented by oxidative stress and inflammatory processes which contribute to the high prevalence of neuropsychiatric disorders, cognitive impairment, and dementia during the natural history of chronic kidney …