Medicine and Health Sciences Commons^™

Evaluating Sex-Dependent Changes In The Gut Microbiome Caused By Polychlorinated Biphenyl (Pcb) Exposure., Zayna Qaissi

College of Arts & Sciences Senior Honors Theses

Polychlorinated biphenyls (PCBs) are persistent organic pollutants that have been associated with fatty liver disease, cardiovascular diseases, and other metabolic dysfunctions. Our laboratory group previously demonstrated that exposures to PCBs led to sex-dependent liver outcomes with female mice showing higher susceptibility to PCB- induced liver toxicity. Some of the underlying mechanisms driving these sex-dependent outcomes that were identified included PCB-modulated endocrine disruption. However, the PCB effects on the gut microbiome and the gut liver axis have not been investigated. Therefore, the objective of the current study is to identify PCB-induced changes in the gut microbiome and identify if this could …