Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Strain Differences In Susceptibility To Cisplatin-Induced Renal Fibrosis, Gabrielle B. Oropilla
Strain Differences In Susceptibility To Cisplatin-Induced Renal Fibrosis, Gabrielle B. Oropilla
College of Arts & Sciences Senior Honors Theses
Cisplatin is a potent chemotherapeutic; the dose-limiting side effect of this drug is nephrotoxicity, causing acute kidney injury (AKI) in 30% of adult patients. Patients with cisplatin-induced AKI are more likely to develop end stage renal diseases, particularly chronic kidney disease (CKD), which is marked by the development of fibrosis. Currently, there are no therapeutic interventions for cisplatin-induced kidney injury, which may be due to limitations in the mouse model used to study this type of injury. We have previously developed a repeated dosing regimen of cisplatin (mice treated with 7 mg/kg once a week for 4 weeks, mice sacrificed …
The Comparison Of Effective Education Methods To Increase Knowledge About Alzheimer's Disease., Lillian M. Kopsolias
The Comparison Of Effective Education Methods To Increase Knowledge About Alzheimer's Disease., Lillian M. Kopsolias
College of Arts & Sciences Senior Honors Theses
Alzheimer’s disease (AD) is a disease most people recognize, but have many misconceptions about. One way to decrease the amount of misconceptions about AD is to educate the general public on the disease. Many educational methods, such as person-centered care education, have been researched, but none have focused on the general public. Therefore, the purpose of this study is to compare two educational methods used today, reading a passage from a reliable online source (traditional educational method) and watching documentaries (person-centered care educational method), to find if a specific way of presenting them will prove efficient for Alzheimer’s education. The …
Enhancement Of Nafld Risk By Vinyl Chloride : Role Of Adipose Tissue In A Mouse Model., Brenna R. Kaelin
Enhancement Of Nafld Risk By Vinyl Chloride : Role Of Adipose Tissue In A Mouse Model., Brenna R. Kaelin
College of Arts & Sciences Senior Honors Theses
Background: Vinyl chloride (VC), an environmental contaminant, is directly hepatotoxic at high concentrations. However, our group has recently demonstrated that VC and the VC metabolite chloroethanol (CE), at concentrations that are not considered hepatotoxic, enhanced liver injury caused by high-fat diet (HFD). These data therefore suggest that the impact of VC exposure on hepatic tissue may be enhanced with underlying metabolic syndrome and/or liver injury. It is known that there is an axis between adipose and hepatic tissue in non-alcoholic fatty liver disease (NAFLD), with the former impacting pathology in the hepatic tissue via release of pro-inflammatory cytokines and/or lipolysis. …
Targeting Cancer Stem Cells In Recurrent Lung Cancer., Karen T. Udoh
Targeting Cancer Stem Cells In Recurrent Lung Cancer., Karen T. Udoh
College of Arts & Sciences Senior Honors Theses
Lung cancer is the leading cause of cancer mortality in the United States. The development of drug resistance with cisplatin or platinum/taxane combination chemotherapies has led patients to suffer from recurrent lung cancer. These chemotherapy treatments target cancer cells but leave behind cancer stem cells (CSCs). CSCs are stem-like tumor cells that have the potential to differentiate and proliferate. This allows the cancer to relapse even after initial elimination of the tumor. Investigations were performed on a secondary metabolite from the Myrothecium fungus family called Verrucarin J (VJ) to see its effects in lung cancer cell lines. VJ significantly inhibits …