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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
An In Vitro Study On The Detection Of Ovarian Cancer Using A Novel Ph-Specific Targeting Polypyrrole Nanocontrasting Agent., Phillip Chuong
An In Vitro Study On The Detection Of Ovarian Cancer Using A Novel Ph-Specific Targeting Polypyrrole Nanocontrasting Agent., Phillip Chuong
College of Arts & Sciences Senior Honors Theses
Longitudinal tracking and accumulation of polymeric nanoparticles in the context of cancer has largely occurred through identification of a fluorescent cargo. In this study, we created a dual extracellular acidic pH targeted polypyrrole-based hollow nanoparticle as a theranostic (maintain both therapeutic and diagnostic capabilities) agent for improved detection and treatment of ovarian cancer. Polypyrrole-hollow nanospheres (PPy-CS) were fabricated through the removal of a silver chloride (AgCl) core, which served as a template, followed by coating with chitosan and further tumor targeted with a pH low insertion peptide, V7. We exploited the NIR-absorbing property of polypyrrole to track both the nanoparticle …
Making Sex Work For The State : The Policing Of Sex Work In The United States., Madeline A Clabough
Making Sex Work For The State : The Policing Of Sex Work In The United States., Madeline A Clabough
College of Arts & Sciences Senior Honors Theses
This thesis analyzes the ways that sex work is regulated within the United States, and analyze the ways that regulation is shaped by contemporary feminist discourse. To do so, it analyzes the ways in which sex workers have been and pathologized since the 19th century, and address the ways that these conceptualizations have been incorporated into the legal regulation of sex workers. Finally, this thesis will look to contemporary practices in the state regulation of sex workers, and argue that the relationship between neoliberalism, the carceral state, and what has come to be termed “carceral feminism” operate in conjunction to …
Cross-Cultural Investigation Of Birth Experience : A Comparison Between Mexico And The United States., Alice J Darling
Cross-Cultural Investigation Of Birth Experience : A Comparison Between Mexico And The United States., Alice J Darling
College of Arts & Sciences Senior Honors Theses
This study investigates the maternal birth experience through a cross-cultural lens. While the field of medical anthropology has researched birth practices of many cultures, few cross-cultural studies have been performed and no recent studies have suggested a transition in birthing. Ethnographic interviews with women and practitioners in Yucatán, Mexico and with women in Kentucky, United States allowed for a better understanding of the respective birthing environments. Grounded theory was then employed to develop a birth transition theory explaining changes occurring when society transitions from traditional birth practitioners to allopathic birth practitioners. The themes of knowledge, expectation and power were isolated …
Investigating The Mechanism Of Novel Anticancer Agent, As1411 : Does Metabolism To Guanine Play A Role?, Parker T Howard
Investigating The Mechanism Of Novel Anticancer Agent, As1411 : Does Metabolism To Guanine Play A Role?, Parker T Howard
College of Arts & Sciences Senior Honors Theses
AS1411 is an oligonucleotide that has shown promising results in lab experiments and clinical trials as an anti-cancer drug, Likewise, treatments with guanine based purine compounds (GBPCs) have demonstrated similar anti-proliferative effects in vitro. This activity is dependent on the HGPRT enzyme. Similarities in activity and physical structure has led us to believe that AS1411 and GBPCs operate by a similar mechanism. To test this, we compare the activity of both in the presence of HGPRT siRNAs and HGPRT deficient cells. While siRNA treatment was unable to alter the activity of GBPCs or AS1411 in our cell lines, HGPRT deficient …
Synthesis Of A Nanoscale Gold-Coated, Thermoresponsive Molecular Release System., Ryan C. Weegens
Synthesis Of A Nanoscale Gold-Coated, Thermoresponsive Molecular Release System., Ryan C. Weegens
College of Arts & Sciences Senior Honors Theses
The work presented here was performed in conjunction with an experimental group in order to prove the concept that an alternating magnetic field (AMF) could be used to induce an intramolecular cyclization to effect payload release. The system studied here consisted of a fluorophore tethered to gold-coated iron oxide nanoparticles (Fe3O4 NPs) via an organic linker consisting of 2 key elements: a carbonate (electrophile) and an amine (nucleophile). Connected to the carbonate was the fluorophore, anthracene, which was attached to the organic linker system by means of an oxime ether linkage. This thesis work served as the …