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Full-Text Articles in Medicine and Health Sciences
Titrating Clozapine Amidst Recommendations Proposing High Myocarditis Risk And Rapid Titrations, Jose De Leon, Y.-L. Tang, T. Baptista, D. Cohen, P. F. J. Schulte
Titrating Clozapine Amidst Recommendations Proposing High Myocarditis Risk And Rapid Titrations, Jose De Leon, Y.-L. Tang, T. Baptista, D. Cohen, P. F. J. Schulte
Psychiatry Faculty Publications
No abstract provided.
Phenoconversion And Therapeutic Drug Monitoring, Jose De Leon
Phenoconversion And Therapeutic Drug Monitoring, Jose De Leon
Psychiatry Faculty Publications
No abstract provided.
Clozapine For Treatment-Resistant Bipolar Disorder: A Systematic Review, Xian-Bin Li, Yi-Lang Tang, Chuan-Yue Wang, Jose De Leon
Clozapine For Treatment-Resistant Bipolar Disorder: A Systematic Review, Xian-Bin Li, Yi-Lang Tang, Chuan-Yue Wang, Jose De Leon
Psychiatry Faculty Publications
Objective
To evaluate the efficacy and safety of clozapine for treatment-resistant bipolar disorder (TRBD).
Methods
A systematic review of randomized controlled studies, open-label prospective studies, and retrospective studies of patients with TRBD was carried out. Interventions included clozapine monotherapy or clozapine combined with other medications. Outcome measures were efficacy and adverse drug reactions (ADRs).
Results
Fifteen clinical trials with a total sample of 1,044 patients met the inclusion criteria. Clozapine monotherapy or clozapine combined with other treatments for TRBD was associated with improvement in: (i) symptoms of mania, depression, rapid cycling, and psychotic symptoms, with many patients with TRBD achieving …
Designer Receptors Enhance Memory In A Mouse Model Of Down Syndrome, Ashley M. Fortress, Eric D. Hamlett, Elena M. Vazey, Gary Aston-Jones, Wayne A. Cass, Heather A. Boger, Ann-Charlotte E. Granholm
Designer Receptors Enhance Memory In A Mouse Model Of Down Syndrome, Ashley M. Fortress, Eric D. Hamlett, Elena M. Vazey, Gary Aston-Jones, Wayne A. Cass, Heather A. Boger, Ann-Charlotte E. Granholm
Neuroscience Faculty Publications
Designer receptors exclusively activated by designer drugs (DREADDs) are novel and powerful tools to investigate discrete neuronal populations in the brain. We have used DREADDs to stimulate degenerating neurons in a Down syndrome (DS) model, Ts65Dn mice. Individuals with DS develop Alzheimer's disease (AD) neuropathology and have elevated risk for dementia starting in their 30s and 40s. Individuals with DS often exhibit working memory deficits coupled with degeneration of the locus coeruleus (LC) norepinephrine (NE) neurons. It is thought that LC degeneration precedes other AD-related neuronal loss, and LC noradrenergic integrity is important for executive function, working memory, and attention. …