Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (2)
- Pharmacology (2)
- Pharmacology, Toxicology and Environmental Health (2)
- Psychiatry and Psychology (2)
- Behavior and Behavior Mechanisms (1)
-
- Behavioral Neurobiology (1)
- Disease Modeling (1)
- Diseases (1)
- Mental Disorders (1)
- Mental and Social Health (1)
- Molecular and Cellular Neuroscience (1)
- Neuroscience and Neurobiology (1)
- Other Pharmacy and Pharmaceutical Sciences (1)
- Other Physiology (1)
- Pharmacy and Pharmaceutical Sciences (1)
- Physiology (1)
- Substance Abuse and Addiction (1)
- Publication Type
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Personality Disorders And Health Problems Distinguish Suicide Attempters From Completers In A Direct Comparison, Lucas Giner, Hilario Blasco-Fontecilla, M. Mercedes Perez-Rodriguez, Rebeca Garcia-Nieto, Jose Giner, Julio A. Guija, Antonio Rico, Enrique Barrero, Maria Angeles Luna, Jose De Leon, Maria A. Oquendo, Enrique Baca-Garcia
Personality Disorders And Health Problems Distinguish Suicide Attempters From Completers In A Direct Comparison, Lucas Giner, Hilario Blasco-Fontecilla, M. Mercedes Perez-Rodriguez, Rebeca Garcia-Nieto, Jose Giner, Julio A. Guija, Antonio Rico, Enrique Barrero, Maria Angeles Luna, Jose De Leon, Maria A. Oquendo, Enrique Baca-Garcia
Psychiatry Faculty Publications
Background
Whether suicide attempters and completers represent the same population evaluated at different points along a progression towards suicide death, overlapping populations, or completely different populations is a problem still unresolved.
Methods
446 Adult suicide attempters and knowledgeable collateral informants for 190 adult suicide probands were interviewed. Sociodemographic and clinical data was collected for both groups using semi-structured interviews and structured assessments. Univariate analyses and logistic regression models were conducted to explore the similarities and differences between suicide attempters and completers.
Results
Univariate analyses yielded significant differences in sociodemographics, recent life events, impulsivity, suicide intent, and distribution of Axis I …
Methylphenidate And Atomoxetine Treatment During Adolescence In The Spontaneously Hypertensive Rat: Mechanisms Underlying High Cocaine Abuse Liability In Attention Deficit/Hyperactivity Disorder, Sucharita S. Somkuwar
Methylphenidate And Atomoxetine Treatment During Adolescence In The Spontaneously Hypertensive Rat: Mechanisms Underlying High Cocaine Abuse Liability In Attention Deficit/Hyperactivity Disorder, Sucharita S. Somkuwar
Theses and Dissertations--Pharmacy
Effects of pharmacotherapies for Attention Deficit/Hyperactivity Disorder (ADHD) on cocaine abuse liability in ADHD are not understood. Spontaneously Hypertensive Rats (SHR), an ADHD model, exhibited greater cocaine self-administration than control Wistar-Kyoto and Wistar rats. Methylphenidate, but not atomoxetine during adolescence enhanced cocaine self-administration in adult SHRs compared to controls. The mesocortical dopaminergic system, including medial prefrontal (mPFC) and orbitofrontal (OFC) cortices, is important for ADHD and cocaine addiction. Dopamine and norepinephrine transporter (DAT and NET) are molecular targets for methylphenidate, atomoxetine and cocaine action.
In the current studies, SHR, Wistar-Kyoto and Wistar were administered methylphenidate (1.5 mg/kg/day, p.o.), atomoxetine (0.3 …
Diet-Induced Obesity: Dopaminergic And Behavioral Mechanisms As Outcomes And Predictors, Vidya Narayanaswami
Diet-Induced Obesity: Dopaminergic And Behavioral Mechanisms As Outcomes And Predictors, Vidya Narayanaswami
Theses and Dissertations--Pharmacy
Obesity and drug abuse share common neural circuitries including the mesocoticolimbic and striatal dopamine reward system. In the current study, a rat model of diet-induced obesity (DIO) was used to determine striatal dopamine function, impulsivity and motivation as neurobehavioral outcomes and predictors of obesity. For the outcome study, rats were randomly assigned a high-fat (HF) or a low-fat (LF) diet for 8 wk. Following the 8-wk HF-diet exposure, rats were segregated into obesity-prone and obesity-resistant groups based on maximum and minimum body weight gain, respectively, and neurobehavioral outcomes were evaluated. For the predictor study, neurobehavioral antecedents were evaluated prior to …