Medicine and Health Sciences Commons^™

Metal Fabrication Shop Owner Dies When Crushed By Falling Steel Plate, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On December 15, 2003, a metal fabrication shop owner died when a 4,000 pound steel base plate fell on him. While inside the shop building, the work crew of least three men, including the owner, fabricated a 10’x 20’ steel base plate to be used at a water treatment plant. The base plate was to house or serve as a bas anchor a large water pump. After welding connectors and channel iron beams to one side of the plate, the crew pushed the plate through a bay door with a forktruck to an outside area in back of the shop. …

Divergent Effects Of Peroxisome Proliferator-Activated Receptor Γ Agonists And Tumor Necrosis Factor Α On Adipocyte Apoe Expression, Lili Yue, Neda Rasouli, Gouri Ranganathan, Philip A. Kern, Theodore Mazzone

Clinical and Translational Science Faculty Publications

ApoE is expressed in multiple mammalian cell types in which it supports cellular differentiated function. In this report we demonstrate that apoE expression in adipocytes is regulated by factors involved in modulating systemic insulin sensitivity. Systemic treatment with pioglitazone increased systemic insulin sensitivity and increased apoE mRNA levels in adipose tissue by 2-3-fold. Treatment of cultured 3T3-L1 adipocytes with ciglitazone increased apoE mRNA levels by 2-4-fold in a dose-dependent manner and increased apoE secretion from cells. Conversely, treatment of adipocytes with tumor necrosis factor (TNF) α reduced apoE mRNA levels and apoE secretion by 60%. Neither insulin nor a peroxisome …

Methods And Apparatus For In Vivo Identification And Characterization Of Vulnerable Atherosclerotic Plaques, Pedro Moreno, Robert A. Lodder, William O'Connor, James E. Muller

Internal Medicine Faculty Patents

Methods and apparatus for analyzing the chemical composition of vulnerable plaques with an intravascular catheter having a near-infrared light source, a fiber-optic probe, a mechanism for directing the light from the light source into a blood vessel, and detectors for detecting light reflected or scattered by the tissue. The light source may be a tunable laser, and may transmit an incident beam having a wavelength ranging from 1400 to 4100 nm. A computer may be included to receive and process the spectral data in the analysis of the vulnerable plaques. A catheter system may be configured to provide near-IR spectrometric …

38 Year-Old Construction Laborer Dies When Trench Walls Collapse, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On November 3, 2003, a 38-year-old male construction laborer died when the unprotected 8-foot high walls of the trench he was working in collapsed. The decedent was working for a subcontractor who was contracted by a construction company to remove old gas, storm and sanitary sewer lines and install similar new lines. The old abandoned 6-inch diameter gas line was a high pressure, 300 – 320 psi gas line in 10-inch steel casing and was 600 feet long. There were five employees at the job site employed by the subcontractor; a foreman who was a certified competent person, a lab …

Laborer Dies When Caught In Arms Of A Skidsteer Loader, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On September 19, 2003, a 23-year-old male laborer (decedent) died when he became caught in the activated arms of a skidsteer loader. A work crew consisting of a contractor and 3 laborers had spent the day installing fence on a dairy farm. Earlier in the day, the contractor had borrowed a skidsteer from the farm owner. The work crew used the skidsteer to set fence posts in the ground. At the end of the work day (approximately 4:00 PM), the contractor instructed the decedent to return the skidsteer to the barn area. From the work site, the decedent drove the …

Licensed Electrician Dies When Electrocuted By 480volts, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On July 4, 2003, a 36-year-old male lead electrician died after being electrocuted with 480 volts of electricity. A crew of five licensed electricians were working at an automotive supply manufacturing facility running wires to connect service for two air conditioning units (3-phase; 480 volts; 30 amp and 35 amp) and service for a lighting panel (3-phase; 277/480 volts and 200 amps). The manufacturing facility had been shut down for the holiday, and besides a facilities office worker in the facilities main office, the five men were the only workers at the site and had complete control of the facility …

Felix Platter: A Sixteenth-Century Medical Student, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

No abstract provided.

Workers Crushed By Vehicles, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Motor Vehicle

To prevent motor vehicle repair injuries:

• Ensure that vehicles are positively restrained from moving with chocks.
• Do not place jack stands under potential moving vehicle parts.
• The space under a jack-suspended vehicle should not be entered unless suitable vehicle support stands are utilized.

Trabajadores Aplastados Por Vehículos, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Motor Vehicle

Para prevenir lesiones relacionadas con la reparación de automotores:

1. Asegúrese de que los vehículos estén firmemente inmovilizados con tacos.
2. No coloque los soportes bajo partes del vehículo que se puedan mover.
3. No se debe ocupar el espacio entre un vehículo suspendido con gato y el suelo a menos que se haga uso de bases de soporte adecuadas para el mismo.

Insulin Sensitivity Following Agent Orange Exposure In Vietnam Veterans With High Blood Levels Of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin, Philip A. Kern, Sufyan Said, William G. Jackson Jr., Joel E. Michalek

Clinical and Translational Science Faculty Publications

Our objective was to determine whether insulin sensitivity was related to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Vietnam veterans exposed to Agent Orange. Air Force veterans of Operation Ranch Hand, the unit responsible for spraying Agent Orange and other herbicides in Vietnam from 1962 to 1971, and comparison veterans who did not spray herbicides were included. We measured insulin sensitivity (S_I) using a frequently sampled iv glucose tolerance test in a matched study of 29 matched pairs of veterans and a quantitative insulin sensitivity check index (QUICKI) based on fasting glucose and insulin in 71 matched pairs. No group differences were …

Method Of Inhibiting Alu Rna And Therapeutic Uses Thereof, Jayakrishna Ambati

Ophthalmology and Visual Science Faculty Patents

The presently-disclosed subject matter includes methods of identifying an Alu RNA inhibitor, and methods and compo sitions for inhibiting Alu RNA. Methods and compositions can be used for the treatment of geographic atrophy and other conditions of interest.

Similar Promotion Of Abeta1-42 Fibrillogenesis By Native Apolipoprotein E Epsilon3 And Epsilon4 Isoforms, David Sweeney, Ralph Martins, Harry Levine, Jonathan D. Smith, Sam Gandy

Sanders-Brown Center on Aging Faculty Publications

The apolipoprotein E epsilon4 allele contributes to the genetic susceptibility underlying a large proportion (~40-60%) of typical, sporadic Alzheimer disease. Apolipoprotein E deficient mice made transgenic for human apolipoprotein E epsilon4 accumulate excess cerebral amyloid when compared to similarly prepared mice expressing human apolipoprotein E epsilon3. Therefore, it is important to search for relevant interactions(s) between apolipoprotein E epsilon4 and Abeta in order to clarify the biological role for apolipoprotein E epsilon4 in Alzheimer disease. Using a thioflavine T (ThT)-based assay, we have investigated the effects of native human apolipoprotein E isoforms on the kinetics of Abeta fibrillogenesis. No obvious …

Il-5 Links Adaptive And Natural Immunity In Reducing Atherosclerotic Disease, Alan Daugherty, Debra L. Rateri, Victoria L. King

Gill Heart & Vascular Institute Faculty Publications

Oxidized LDL induces changes in several facets of the immune system, although the relationships between these facets and their contributions to atherogenesis have yet to be fully elucidated. A report in this issue of the JCI provides a novel demonstration of the adaptive immune system influencing the production of natural antibodies. The results demonstrate that injection of malondialdehyde-modified LDL promotes a Th2 response that in turn increases the titers of the natural antibody T15/EO6, which recognizes the oxidized phospholipid POVPC. Atherosclerotic lesion size in LDL receptor–deficient mice is reduced as a consequence of the increase in natural antibody titers, and …

Homicides In The Workplace, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Other

To prevent workplace violence:

• Assessment for workplace violence risks should be done in all workplaces.
• Workplaces should have policies that clearly delineate that violence is not appropriate during any workplace interaction and violence policies should mirror other workplace policies in terms of strategies for reporting and investigation of incidents, and progressive discipline.
• A clear and consistent reporting system for workplace violence should be in place and every worker should understand how it works.
• Safety training should be attended by employers, supervisors, and employees.
• Policy, training, and employee assistance for domestic violence should be implemented in collaboration with community service providers.

Homicidios En El Lugar De Trabajo, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Other

Para prevenir la violencia ocupacional:

Una valoración de los riesgos de violencia ocupacional deberá ser llevada a cabo en todos los lugares de trabajo.

Los lugares de trabajo deben implementar políticas que aclaren que la violencia no es apropiada durante ninguna interacción laboral; de igual forma las políticas sobre violencia deberán reflejar los procedimientos del lugar de trabajo en términos de estrategias para reportar e investigar los casos y la progresión de la disciplina.

Un sistema de reporte de la violencia laboral claro y consistente deberá ser implementado en el lugar de trabajo, y cada trabajador deberá comprender como funciona. …

Permeable, Water Soluble, Non-Irritating Prodrugs Of Chemotherapeutic Agents With Oxaalkanoic Acids, Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, Paul Ashton

Pharmaceutical Sciences Faculty Patents

The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof.

Clinical Profiles, Occurrence, And Management Of Adolescent Patients With Hair-An Syndrome, Hatim A. Omar, Stephanie Logsdon, Jessica Richards

Pediatrics Faculty Publications

The syndrome of hyperandrogenism, insulin resistance, and acanthosis nigricans (HAIR-AN) is a subphenotype of the polycystic ovary syndrome. It is one of the most common causes of menstrual problems, hyperandrogenic symptoms, and insulin resistance among young women. Review of clinical data in an outpatient adolescent clinic showed that of the 1,002 young women (ages 10-21 years) attending the clinic over a 2-year period, 50 (5%) were diagnosed with HAIR-AN syndrome. Mean age of the patients was 15.5, initial mean weight at diagnosis was 94.5 kg, and the mean BMI was 33.33 kg/m2. Patients were treated with a weight-stabilization and -reduction …

Long-Term Evaluation Of The Use Of The Transdermal Contraceptive Patch In Adolescents, Stephanie Logsdon, Jessica Richards, Hatim A. Omar

Pediatrics Faculty Publications

The transdermal contraceptive patch, Ortho Evra™, was approved in December 2001 and released on the market in June 2002. In this study, we reviewed clinical data of young women who started the patch between June 2002 and December 2003 in the adolescent medicine clinic at a university-based outpatient center. A total of 62 patients started the patch in that period and two of them were lost to follow-up. Mean age of patients was 17.9 years and mean length of use was 10 cycles. Only 10 patients (16.7%) discontinued use. Reasons for discontinuation were moderate to severe skin irritation (3 patients, …

Social Support Protects Against The Negative Effects Of Partner Violence On Mental Health, Ann L. Coker, Paige H. Smith, Martie P. Thompson, Robert E. Mckeown, Lesa Bethea, Keith E. Davis

CRVAW Faculty Journal Articles

Objectives: Social support for abused women may reduce the impact of abuse on mental health, yet few studies have addressed this issue. We wish to determine associations between intimate partner violence (IPV) and mental health outcomes and to assess the protective role of abuse disclosure and support on mental health among abused women.

Methods: A cross-sectional survey was conducted of 1152 women, ages 18–65, recruited from family practice clinics from 1997 through 1999. They were screened for IPV during a brief in-clinic interview, and physical and mental health status was assessed in a follow-up interview.

Results: IPV, defined as sexual, …

Methods For Increasing Leptin Levels Using Nicotinic Acid Compounds, Elaine L. Jacobson, Myron Jacobson, Hyuntae Kim

Graduate Center for Nutritional Sciences Faculty Patents

The invention relates to the use of nicotinic acid and nicotinic acid esters, such as nicotinic acid alkyl esters, to increase the amount of leptin in a subject. As a result, one can treat conditions, such as conditions characterized by wounds, by administering sufficient amounts of nicotinic acid or nicotinic acid ester to increase leptin levels to alleviating amounts. Various conditions and modes of treatment are disclosed.

Influence Of Varied, Controlled Distances From The Crank Axis On Peak Physiological Responses During Arm Crank Ergometry, Thomas L. Miller, Carl G. Mattacola, Mayra C. Santiago

Physical Therapy Faculty Publications

The purpose of the study was to determine the influence of varied, controlled distances from the crank axis during arm crank ergometry (ACE) on peak physiological responses and physical work capacity (PWC). Physiological responses to ACE were evaluated using three controlled distances from the crank axis based on 0°, 15°, and 30° from full extension in the elbow while at the furthest point in the crank rotation. Eleven adult, able-bodied women (age = 24.5 ± 4.7 yrs) performed graded maximal ACE tests at each of three distances from the crank axis. Data were analyzed for differences in peak physiological responses …

Roofing Laborer Dies After 60-Foot Fall, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Falls

At 8:00 AM on the morning of October 7, 2003, a 33-year-old laborer, working for a roofing contractor, was removing debris from a commercial building roof when he slipped and fell 60 feet to the sidewalk below. There were 2 other laborers and the contractor at the work site that morning. It was the second work day at this particular job site and the three workers were to finish discarding bags of debris from the roof. The decedent and one of the laborers accessed the roof through the building interior, up a flight of stairs to a five-step ladder which …

Master Plumber Dies When Trench Collapses, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On July 29, 2003, a 35-year-old, male master plumber died when an unshorn trench collapsed. Two employees from the contracting company were speaking with him at the time from the side of the trench. He had searched and diagnosed a water line leak when the walls of the trench collapsed. The plumber was employed by a plumbing company contracted by a commercial establishment to locate and repair a water leak. He died at the scene from asphyxia due to chest compression.

To prevent future occurrences of similar incidents, the following recommendations have been made:

Recommendation No. 1: Employers should train …

Methods To Impair Hematologic Cancer Progenitor Cells And Compounds Related Thereto, Craig Jordan

Internal Medicine Faculty Patents

Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML) and chronic lymphoid leukemia (CLL). Interleukin-3 receptor alpha chain (IL-3Rα or CD123) is strongly expressed on progenitor hematologic cancer cells, but is virtually undetectable on normal bone marrow cells. The present invention provides methods of impairing progenitor hematologic cancer (e.g., leukemia and lymphomic) cells by selectively targeting cells expressing CD123. These methods are useful in the detection and treatment of leukemias and malignant lymphoproliferative disorders. Also provided are compounds useful …

Method For Identifying Regulators Of Protein-Advanced Glycation End Product (Protein-Age) Formation, Elaine L. Jacobson, Myron Jacobson, Georg T. Wondrak

Graduate Center for Nutritional Sciences Faculty Patents

The invention relates to methods for identifying compounds which affect cellular stress. In particular, the method relates to identifying compounds which inhibit protein advanced glycation end product formation, where the compounds are carbonyl scavengers which inhibit the formation. The assay involves combing the substance of interest with histone H1 and ADP-ribose, and then measuring fluorescence and protein cross linking. Various inhibitors of protein AGE glycation have been identified, using this assay.

2,6-Disubstituted Piperidines As Modulators Of Nicotinic Acetylcholine Receptor Mediated Neurotransmitter Release, Uptake And Storage, Peter A. Crooks, Linda P. Dwoskin, Dennis Keith Miller, Vladimir P. Grinevich, Seth Davin Norrholm, Guangrong Zheng

Pharmaceutical Sciences Faculty Patents

Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder or for a CNS disease or pathology . . .

To see the remainder of this abstract, please download this patent.

Highway Construction Worker Dies When Struck By Semi-Tractor Trailer, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

At approximately 8:30 am on April 16, 2003, a 48-year-old male (decedent) highway construction laborer working in an interstate highway median, died when he was struck by an out-of-control double trailer (a semi-truck pulling two trailers). The laborer was speaking with the job foreman and another laborer in the median next to a grading machine. As the decedent looked toward the traffic, he saw a double trailer traveling on the right-hand shoulder swerve into the left-hand lane and drive into the median where all three men were standing. He told the other two to get out of the way as …

Construction Laborer Dies From Heat Stroke At End Of Workday, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On June 27, 2003, a 41-year-old, male laborer died from heat stroke one day after being taken to the hospital. The laborer was working on an addition to a factory sawing boards to make concrete forms. He worked until 5:00 pm that day and was in the parking lot on his way to his vehicle when he apparently collapsed beside his vehicle. A worker on the second shift at the factory was taking scrap material outside to a dumpster when he found the laborer on the ground. The factory worker returned to the plant and told his supervisor there was …

28-Year-Old Man Dies After Falling With Lift, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Falls

On June 27, 2003, a 28-year-old male sound technician died due to injuries received after falling approximately 50 feet from a lift. Three men (one chief sound engineer and two sound technicians) were sent to repair a sound system in a school gymnasium. Upon arriving and assessing the situation, the three diagnosed that a particular speaker, located in the rafters, should be removed from its location. Using a 30-year-old telescoping, self-leveling lift belonging to the school, the chief engineer used controls located at the base of the lift, to hoist the two sound technicians to the speaker in the rafter. …

Fatal Tractor Overturns: Don't Let Them Roll Over You!, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Tractors/Logging

To prevent tractor injuries:

• All tractors should be equipped with a Roll Over Protective Structure (ROPS) and a seat belt.
• Tractors should be equipped with front-end counterweights and tractor wheels
• should be weighted to increase stability.
• Community farm safety training with safe operating procedures and hazard identification should be offered to novice or limited- experience operators.