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Association Between Cerebrovascular Pathology And Anti-Hypertensive Treatment In Diabetics, Gary Owen
Association Between Cerebrovascular Pathology And Anti-Hypertensive Treatment In Diabetics, Gary Owen
Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)
Background
Dementia is a growing public health concern as the population ages. Vascular dementia is the second most common type of dementia behind Alzheimer’s, and is caused by cerebrovascular damage, such as infarcts and hemorrhages. As in systemic cardiovascular disease, diabetes and hypertension are leading risk factors for cerebrovascular pathology. Anti-hypertensive treatment (AHT), therefore, may have a role in preventing cerebrovascular damage.
Methods
A case-control study design was utilized to evaluate any association between AHT during life and cerebrovascular pathology in autopsy in diabetic participants from the National Alzheimer’s Coordinating Centers (NACC). Pathology outcomes included infarcts of various sizes and …