Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Pharmaceutics and Drug Design (4)
- Analytical Chemistry (2)
- Chemicals and Drugs (2)
- Chemistry (2)
- Diseases (2)
-
- Other Pharmacy and Pharmaceutical Sciences (2)
- Physical Sciences and Mathematics (2)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biotechnology (1)
- Cardiovascular Diseases (1)
- Cellular and Molecular Physiology (1)
- Life Sciences (1)
- Lipids (1)
- Medicinal and Pharmaceutical Chemistry (1)
- Mental Disorders (1)
- Mental and Social Health (1)
- Natural Products Chemistry and Pharmacognosy (1)
- Nervous System Diseases (1)
- Nutritional and Metabolic Diseases (1)
- Pharmaceutical Preparations (1)
- Pharmacology (1)
- Pharmacology, Toxicology and Environmental Health (1)
- Pharmacy Administration, Policy and Regulation (1)
- Physical Chemistry (1)
- Physiology (1)
- Psychiatric and Mental Health (1)
- Psychiatry and Psychology (1)
- Keyword
-
- ABCG5/ABCG8 (1)
- Amorphous solid dispersion (1)
- Antinociceptive activity (1)
- Anxiety (1)
- Biofilm (1)
-
- Crystallinity (1)
- Drug delivery (1)
- Fentanyl (1)
- Fluorescent bioassay (1)
- GABAA receptor allosteric modulators (1)
- Gene delivery (1)
- Glass transition temperature (1)
- Gum inflammation (1)
- HIV Prevention (1)
- Hepatobiliary Cholesterol Excretion (1)
- Hydrogen bonding (1)
- Immune modulation (1)
- Lipoprotein Metabolism (1)
- Liposome (1)
- MOR antagonist (1)
- Naltrexone (1)
- Oral dysbiosis (1)
- Oral microbiome species (1)
- Periodontal disease (1)
- Physical stability (1)
- PrEP access (1)
- Pre-exposure prophylaxis (1)
- Reverse Cholesterol Transport (1)
- Solid-state nuclear magnetic resonance spectroscopy (1)
- Structure-activity relationship (1)
Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
Building Tools For Improved Modulation Of The Human Gabaa Receptor, A Central Nervous System Target For The Treatment Of Anxiety, Garrett Edward Zinck
Building Tools For Improved Modulation Of The Human Gabaa Receptor, A Central Nervous System Target For The Treatment Of Anxiety, Garrett Edward Zinck
Theses and Dissertations--Pharmacy
In the U.S., anxiety is recognized as an increasing range of mentally and physically debilitating psychiatric health disorders with significant economic repercussions. Over the last 20 years, several novel anti-anxiety therapies have entered the drug development pipeline, but none have made it to market.
The work in this dissertation focused on structurally modifying valerenic acid (VA), a structurally unique carboxylated sesquiterpene acid found in Valeriana officinalis. VA is putatively reported to have allosteric modulatory activity of the human GABAA receptor, a ligand-gated ion channel responsible for attenuating neurotransmissions. Structural modeling of VA’s GABAA receptor interaction suggests that …
Studies Toward The Development Of An Improved Countermeasure For Synthetic Opioid Overdose, Sidnee L. Hedrick
Studies Toward The Development Of An Improved Countermeasure For Synthetic Opioid Overdose, Sidnee L. Hedrick
Theses and Dissertations--Pharmacy
One of the most prominent opioid analgesics in the United States is the high potency agonist fentanyl. It is used in the treatment of acute and chronic pain and as an anesthetic adjuvant. When used inappropriately, however, ingestion of just a few milligrams of fentanyl or other synthetic opioid can cause opioid-induced respiratory depression (OIRD), often leading to death. Currently, the treatment of choice for OIRD is the opioid receptor antagonist naloxone. Recent reports, however, suggest that higher doses or repeated dosing of naloxone (due to recurrence of respiratory depression) may be required to fully reverse fentanyl-induced respiratory depression, rendering …
Investigating The Physical Stability Of Amorphous Pharmaceutical Formulations, Travis W. Jarrells
Investigating The Physical Stability Of Amorphous Pharmaceutical Formulations, Travis W. Jarrells
Theses and Dissertations--Pharmacy
Amorphous formulations, including amorphous solid dispersions (ASDs), consisting of the active pharmaceutical ingredient (API) intimately mixed in a polymeric matrix, are an attractive formulation approach to improve drug delivery, dissolution, and solubility. However, an amorphous API in an ASD is in a higher energy state compared to the crystalline drug and results in most ASDs being inherently unstable. The polymer helps to stabilize the amorphous drug against crystallization such that the resulting homogenous mixture maintains its solubility advantage relative to the crystalline form. One challenge of ASDs is that the presence of impurities including crystals or residual solvent, variations in …
Liposomal Technologies To Improve Gene Delivery, David Nardo Padron
Liposomal Technologies To Improve Gene Delivery, David Nardo Padron
Theses and Dissertations--Pharmacy
Lipid based nanoparticles (LBNs) are used in myriad applications in medicine from small molecule drug delivery to mRNA vaccines. A major contributing factor to the development of the field has been the ongoing development of novel compounds that retain the functionality of natural lipids but expand upon them through inclusion of functional moieties that can be applied to specific scientific and biomedical questions. In the body of this dissertation, an extensive overview of LBNs is provided, focusing primarily on their use in immune modulation. The research presented herein begins with the synthesis of a novel class of lipids based on …
Development Of Zafirlukast Derivatives Active Against Porphyromonas Gingivalis, Kaitlind C. Howard
Development Of Zafirlukast Derivatives Active Against Porphyromonas Gingivalis, Kaitlind C. Howard
Theses and Dissertations--Pharmacy
Periodontal diseases are inflammatory diseases that can lead to damage of the soft tissue and bone supporting the teeth. Gingivitis is the reversible early stage of gum disease, which consist of gums that bleed when brushing or flossing teeth. When left untreated, the preventable but irreversible late stage of periodontal disease, periodontitis, can lead teeth to loosen or even fall out. Oral bacterial species, such as the Gram-negative anaerobic pathogen Porphyromonas gingivalis trigger these inflammatory diseases through oral dysbiosis. P. gingivalis is a keystone pathogen, meaning that the damage caused by P. gingivalis is not proportional to its abundance. Treatment …
The Relative Contribution Of Liver And Intestine In Reverse Cholesterol Transport, Rupinder Kaur
The Relative Contribution Of Liver And Intestine In Reverse Cholesterol Transport, Rupinder Kaur
Theses and Dissertations--Pharmacy
Despite decades of advances in research, death due to cardiometabolic disease remains the largest contributor to mortality in the US. While present therapies oppose “forward cholesterol transport,” and atherosclerotic plaque progression, they do not remove cholesterol from established atherosclerotic plaques. Reverse cholesterol transport (RCT) is the active process of mobilizing peripheral cholesterol for excretion through the hepatobiliary (transhepatic cholesterol elimination, THCE) or intestinal (transintestinal cholesterol elimination, TICE) pathways. Currently, there are no clinically approved therapeutics that target RCT. Elucidation of the mechanisms that govern RCT and TICE, and the subsequent identification of novel targets is of importance. The present work …
Analysis Of Potential Facilitators To Use Of Hiv Pre-Exposure Prophylaxis (Prep) In A Young Transgender Population, Noah Dixon
Theses and Dissertations--Pharmacy
Pre-exposure prophylaxis for HIV prevention (PrEP) is heavily under-utilized in transgender youth, a population which experiences high risk factors for contracting HIV and exhibits unique barriers to care. This retrospective study used a secondary data analysis of survey results from transgender youth between 16-and 24-years-old to analyze various exposures for association with PrEP use. It was hypothesized that medical gender affirming therapy, mental health care treatment, and HIV programming would be independently associated with increased use of PrEP in transgender youth. It was found that only HIV prevention services and programming related to HIV or gender identity were associated with …