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Capillaries, Old Age And Alzheimer’S Disease, Charles T. Ambrose
Capillaries, Old Age And Alzheimer’S Disease, Charles T. Ambrose
Microbiology, Immunology, and Molecular Genetics Faculty Publications
Many of the minor complaints of old age may have a common etiology and are grouped together here under the term ‘the lesser ailments of aging’ (LAA). This essay proposes that they are due in large part to an age-linked reduced microcirculation. Capillary density (CD) in the tissues is determined by levels of angiogenic growth factors (AGFs). Over 47 studies have reported a reduced CD and/or waning AGFs throughout the bodies of aging animals and people. More convincing than such a generalization are the 80 sets of data comparing these two parameters in adult vs. the aged. These data have …