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Full-Text Articles in Medicine and Health Sciences
Knockout Of Vascular Early Response Gene Worsens Chronic Stroke Outcomes In Neonatal Mice, Mehwish A. Mirza, Lori A. Capozzi, Yan Xu, Louise D. Mccullough, Fudong Liu
Knockout Of Vascular Early Response Gene Worsens Chronic Stroke Outcomes In Neonatal Mice, Mehwish A. Mirza, Lori A. Capozzi, Yan Xu, Louise D. Mccullough, Fudong Liu
UCHC Articles - Research
Vascular early response gene (Verge) is a novel immediate early gene that is highly expressed during developmental angiogenesis and after ischemic insults in adult brain. However, the role of Verge after neonatal injury is not known. In the present study, we investigated the hypothesis that Verge contributes to vascular remodeling and tissue repair after neonatal ischemic injury. The Rice–Vanucci model (RVM) was employed to induce neonatal stroke in both Verge knockout (KO) and wild-type (WT) postnatal day 10 (P10) mice. Histological and behavioral outcomes at acute (24 h), subacute (7 days) and chronic (30 days) phases were evaluated. Angiogenesis, neurogenesis, …
Neurogenesis Continues In The Third Trimester Of Pregnancy And Is Suppressed By Premature Birth, Nada Zecevic
Neurogenesis Continues In The Third Trimester Of Pregnancy And Is Suppressed By Premature Birth, Nada Zecevic
UCHC Articles - Research
Premature infants exhibit neurodevelopmental delay and reduced growth of the cerebral cortex. However, the underlying mechanisms have remained elusive. Therefore, we hypothesized that neurogenesis in the ventricular and subventricular zones of the cerebral cortex would continue in the third trimester of pregnancy, and that preterm birth would suppress neurogenesis. To test our hypotheses, we evaluated autopsy materials from human fetuses and preterm infants of 16–35 gestational weeks (gw). We noted that both cycling and non-cycling Sox2+ radial glial cells as well as Tbr2+ intermediate progenitors were abundant in human preterm infants until 28 gw. However, their densities consistently …