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Variation In Mu-Opioid Receptor Gene (Oprm1) As A Moderator Of Naltrexone Treatment To Reduce Heavy Drinking In A High Functioning Cohort, Jonathan M. Covault
Variation In Mu-Opioid Receptor Gene (Oprm1) As A Moderator Of Naltrexone Treatment To Reduce Heavy Drinking In A High Functioning Cohort, Jonathan M. Covault
UCHC Articles - Research
Background
It is well known that naltrexone, an FDA-approved medication for treatment of alcohol dependence, is effective for only a subset of individuals. Recent studies have examined the utility of a functional A118G single nucleotide polymorphism (SNP) of the mu-opioid receptor gene (OPRM1) as a predictor of naltrexone treatment response. Although the findings to date have generally been consistent with a moderating effect of the SNP, further evaluation of this hypothesis is warranted.
Objective
To evaluate whether problem drinkers with one or two copies of the 118G allele respond better to naltrexone treatment. The treatment goal in this cohort of …