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Full-Text Articles in Medicine and Health Sciences
Microsome Biocolloids For Rapid Drug Metabolism And Inhibition Assessment By Lc-Ms, Besnik Bajrami, Sadagopan Krishnan, James F. Rusling
Microsome Biocolloids For Rapid Drug Metabolism And Inhibition Assessment By Lc-Ms, Besnik Bajrami, Sadagopan Krishnan, James F. Rusling
UCHC Articles - Research
Rat liver microsomes attached to nanoparticles were used for LC-MS studies of CYP3A and 2E1 enzymes in metabolism of N-nitroso compounds. Using these biocolloids, turnover rates were measured within 2 min. Inhibitor IC50 values for ketoconazole (KET) and 4-methylpyrazole (4-MEP) were estimated.