Medicine and Health Sciences Commons^™

Effectiveness Of Doxycycline As Post-Exposure Prophylaxis (Doxy-Pep) For Bacterial Sexually Transmitted Infections (Stis) Among Men Who Have Sex With Men (Msm) In Central Florida, Micah P. Greer

Honors Undergraduate Theses

Bacterial sexually transmitted infections (STIs), notably syphilis, gonorrhea, and chlamydia, have been increasing among men who have sex with men (MSM) in the United States. The rise has been attributed to various factors, including increased condomless sexual acts due to the high uptake of pre-exposure prophylaxis (PrEP) for HIV prevention. To address this concerning trend, post-exposure prophylaxis with doxycycline (Doxy-PEP) has emerged as a potential biomedical intervention. This study aimed to assess the effectiveness of Doxy-PEP in preventing bacterial STIs among MSM in Central Florida, a region with rising STI rates. A de-identified dataset from Pineapple Health Clinic in Orlando, …

The Ethics Of Brain-Machine Interfaces, Devon J. Lynn

Honors Undergraduate Theses

Brain Machine Interfaces (BMI) are a rapidly developing technology that raise unique ethical issues that demand review. They have demonstrated impressive restorative potential, particularly for individuals living with epilepsy, and those who are locked in. Although BMIs have the potential to provide significant benefit to millions of users, further advancement of the technology should proceed cautiously, according to the guidelines outlined in this paper. Failure to adhere to ethical guidelines could lead to severe privacy concerns, and would violate moral principles of beneficence, virtue ethics, care ethics, and utilitarianism. Despite the moral risks, BMIs hold promise for reshaping future healthcare …

Antagomir Treatment For Deep-Space Simulated Changes In The Liver Of Mice, Natalie P. Hayslip

Honors Undergraduate Theses

With the start of NASA’s Artemis program, astronauts will soon leave the protection of Earth’s magnetosphere. Previous studies have established a theme of liver dysregulation associated with the harmful radiation and microgravity experienced in deep space. MicroRNAs (miRNAs) are key regulators of many of the pathologies observed during and after spaceflight, including hepatic fibrosis, making them strong potential biomarkers and therapeutic targets. Therefore, in the present study we investigated the effects of simulated microgravity, galactic cosmic radiation (GCR), and solar particle events (SPE) on miRNAs and mRNAs involved in the TGF-β signaling pathway, a key regulator of fibrosis, senescence, and …

The Effects Of Resistance Training On Older Adults: Increasing Healthspan And Lowering Disability Rates, Michael M. Samuel

Honors Undergraduate Theses

This study analyzed the research on older adults and resistance training exercise and assessed effects on health span and lowering disability rates. A targeted search of the literature was employed using the following key words: sarcopenia, resistance training, hypertrophy, quality of life, disability, activities of daily living, strength training, falls, and functional strength. These were used to find articles that were relevant to the research. Articles were excluded if they focused on young athletes as they did not meet my research age group. Articles that focused on nutrition were also excluded as they pulled the focus away from the impact …

The Investigation Of The Effects Of Adolescent Substance Use On Socioeconomic Outcomes During Adulthood, Bedis Elkamel

Honors Undergraduate Theses

Background: Adolescence is a crucial point in life where choices, behaviors, and environmental influences can significantly shape future outcomes. This research investigates the increasing concerns surrounding adolescent substance use and examines its long-term effects on socioeconomic status (SES) in adulthood. Substance use during adolescence has been shown to have significant long-term physiological impacts, as the brain is still developing at this age. Additionally, many short- and long-term effects are associated with substance use, such as impacts on academics, physical and emotional well-being, and social life. Several studies have been conducted to explore the relationship between substance use and SES, however, …

Postpartum Depression Among Latina Women: A Literature Review, Juan M. Martinez Jr.

Honors Undergraduate Theses

The Hispanic population in the United States has increased to 62.1 million, significantly shaping the country's demographic landscape, with Hispanic women exhibiting the highest fertility rates. Concurrent with the population's growing trend is an increased prevalence rate of postpartum depression, with Latinas facing heightened risk factors. The inadequate representation of Latinas in postpartum depression research and healthcare guidelines exacerbates their vulnerability. The prevalence of postpartum depression among Latina women makes this condition a serious public health concern. Due to insufficient research on marginalized groups, emphasis is needed on culturally competent healthcare. This literature review aims to explore the underlying factors …

Fertility Preservation: A Critical Review Of Information Available To Testicular Cancer Patients, Markram Groenewald

Honors Undergraduate Theses

Fertility preservation remains a crucial component of Testicular Cancer patients’ health-related quality of life. Significant inconsistency is present in the availability and accessibility of information related to fertility preservation for patients with Testicular Cancer. The purpose of this critical review was to determine the quantity and quality of fertility preservation provided through the websites of top cancer care centers. A total of 15 centers were chosen based on the top cancer centers from US News and World Report and expanded upon using Definitive Healthcare’s top 10 centers treating Testicular Cancer by volume. Webpages were collected and graded for accessibility of …

Assessing Preventive Care Utilization For Cardiovascular Disease Among U.S. Latinos, Melanie Helena Paredes

Honors Undergraduate Theses

Accounting for nearly 19% of the United States population in 2020, Latinos and Hispanics represent the second largest racial/ethnic group in the United States, totaling roughly 62.1 million people. Given the growing population size and longer life expectancy estimates amongst the U.S. Latino/Hispanic community, healthcare practitioners and public health officials are increasingly emphasizing the healthcare needs and outcomes of this population. Alarmingly, current literature has highlighted significant disparities in cardiovascular disease (CVD) incidence and risk factors among U.S. Latinos/Hispanics. As CVD continues to be one of the leading causes of death amongst all racial/ethnic groups across the United States, risk …

Interventions To Alleviate Guilt In Family Caregivers Of Patients Receiving Hospice Or End-Of-Life Care: A Scoping Review, Kyla N. Huelle

Honors Undergraduate Theses

This scoping review contains a literature analysis regarding interventions used by health care workers to alleviate guilt in caregivers of patients during end-of-life care. During end-of-life care, many transitions and decisions are made that add to the burden of caregivers. Family caregivers experience many physical, financial, and emotional stressors during the journey of end-of-life care, and this can result in guilt. Feelings of guilt can lead to poorer health outcomes and coping in family caregivers and should be addressed by health providers. In this scoping review, a literature search was conducted using various key terms like "guilt," "hospice," "end-of-life care," …

Social Determinants Of Chronic Kidney Disease In The Black American Community: A Systematic Review, Addea Coleman

Honors Undergraduate Theses

This systematic review aims to examine the relationship between the social determinants of health that significantly impact the prevalence and progression of chronic kidney disease (CKD) amongst Black Americans. The Black American population has the highest prevalence of CKD in the United States, while concurrently possessing prominent genetic risk factors for this chronic disease. The social determinants: healthcare quality and access (extended to account for health behaviors), social and community context, and economic stability were specifically assessed in this review. Key terms were utilized to search electronic databases PubMed and Web of Science, which yielded 470 unduplicated articles. Twenty-nine articles …

Exploring The Impact Of Cultural Background Among Asian And Non-Hispanic White Populations On Organ Donation, Doyoung Ahn

Honors Undergraduate Theses

Background: The demand for organ donation is increasing but there is always a lack of organ donor supply. To receive an organ donation, specific criteria must be met. Matching criteria between the donor and the recipient is critically important. The likelihood of having a capable organ increases when the donors and recipients have the same ethnicity. However, the number of organ donors differ significantly based on ethnicity.

Purpose: The purpose of this literature review was to explore the impact of cultural background and education among the Asian and non-Hispanic White population on organ donation and how it impacts individuals' decisions …

The Effect Of L-Citrulline Supplementation On Blood Pressure: An Updated Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Vraj Amin

Honors Undergraduate Theses

Cardiovascular disease remains one of the most prevalent diseases in the United States and has remained as the leading cause of death. Large Mendelian randomization studies have found significant correlations between high blood pressure and cardiovascular disease (CVD). In fact, high blood pressure is the single most important independent risk factor for CVD. The purpose of this study was to determine the effect of L-citrulline on blood pressure to determine whether it could be advised as an effective treatment for high blood pressure. L-citrulline is a naturally occurring amino acid that readily converts to L-arginine within the human body. L-arginine …

Post-Intensive Care Syndrome In Survivors Of Acute Respiratory Distress Syndrome (Ards) And Covid-19 Ards: A Descriptive Study, Sara Hassan

Honors Undergraduate Theses

Background: Post-intensive care syndrome (PICS) is an umbrella term for the long-term physical, cognitive, and mental health conditions survivors live with long after an ICU discharge. Mental health conditions experienced by survivors include anxiety, depression, and post-traumatic stress disorder (PTSD). Survivors of acute respiratory distress syndrome (ARDS) and COVID ARDS who were on a ventilator are particularly at risk of developing long-term mental health conditions.

Study Purpose: The purpose of this study was to investigate the severity of anxiety, depression, and PTSD in adult survivors of these two ARDS conditions (COVID ARDS; ARDS) who were admitted to intensive care units …

Nursing Interventions To Decrease Depressive And Anxious Symptoms In Hispanic-American Youth, Vanessa C. Hernandez

Honors Undergraduate Theses

Introduction: Hispanic-American youth are less likely to receive mental health services despite being at increased risk for depression and anxiety. Having depression and anxiety at a young age can have detrimental long-term effects such as sexual risk behavior, delinquency, and suicide. Various kinds of nurses interact with this age group which can be a missed opportunity to intervene for the welfare of these youth. Interventions exist for depression and anxiety; however, they are not specific to nurses who care for young Hispanic-American patients. Methods: An integrative literature review was performed to identify nursing interventions for Hispanic American youth with depression …

Therapeutic Gardening And Its Effects On Depressive Symptoms In Dementia Care, Shannon E. Norton

Honors Undergraduate Theses

Aim: To present a literature review of the positive effects and overall reduction of depressive symptoms that an intervention such as therapeutic gardening has on individuals living within memory care facilities.

Background: As most humans age, they often lose abilities or skills that they have had for their entire lives (e.g. driving, grooming, toileting, seeing and/or hearing). By implementing programs that involve therapeutic garden therapy, individuals with dementia who are at greater risk for clinical depressive symptoms may find that this alternative approach improves their symptoms.

Methods: A comprehensive, electronic, literature search in the CINAHL database was completed and included …

The Relationship Between Evening Screen Time Use And Objectively Measured Sleep Outcomes In U.S. College Students, Donya Sedaghat

Honors Undergraduate Theses

Research suggests that elevated levels of screen time in the evening can negatively impact sleep outcomes (sleep duration, quality, and latency). Yet, there is a lack of evidence exploring if this relationship exists in college students. The purpose of this study is to investigate the relationship between evening screen time use and objectively measured sleep outcomes in US college students. College students (N = 29) junior or senior standing in a Health Sciences major were recruited to participate in this cross-sectional study. Participants wore accelerometers on their wrist for 24hr/day for seven days to capture sleep duration, efficiency, awakenings, and …

Split Catalytic Probes For The Detection Of Monkeypox Virus, Jaehyun Ahn

Honors Undergraduate Theses

The COVID-19 outbreak highlighted the important role that diagnostic tests play in the healthcare system. To reduce the impact of infectious disease outbreaks, the development of rapid and cost-effective point-of-care-tests (POCTs) is crucial. With the dissemination of the Monkeypox (Mpox) virus, it became a necessity to produce POCTS that are inexpensive and easy to use. This work explored the construction of two colorimetric assays that aim to detect Mpox genetic signatures. One is based on the split-peroxidase-like deoxyribozyme probes (sPDz), while the other utilizes a cascade system of split RNA-cleaving deoxyribozyme (sDz) and peroxidase-like deoxyribozyme (PDz). Both rely on catalytic …

Time Until Subsequent Pregnancy After Intrauterine Fetal Demise And Early Infant Death Based On Grieving Strategies, Gertride Delhomme

Honors Undergraduate Theses

The purpose of this research is to evaluate the coping strategies of families and childbearing women after intrauterine fetal demise and early infant death. The secondary purpose is to examine the effect of grieving strategies after intrauterine fetal demise compared to early infant death on time until subsequent pregnancy in women of childbearing age. A literature review exploring parental grief and coping strategies to cope with loss and its effect on the subsequent pregnancy was conducted from various online databases. All reviewed articles in the analysis indicated that coping strategies consist of a diverse number of mechanisms during the bereavement …

The Mental And Dental Repercussions Of Obstructive Sleep Apnea And Its Treatments, Emily E. Mcgoohan

Honors Undergraduate Theses

The purpose of this study is to examine the relationship between dental and mental health. To dive deeper into seeing this connection, patients with sleep apnea will be asked to share their experiences with the treatments for sleep apnea and how it had affected their mental or dental health.

Effect Of Estrogen On Chondrogenesis In Female Articular Chondrocytes, Ebony R. Parsons

Honors Undergraduate Theses

As women age and transition into menopause they face a higher risk of developing osteoarthritis leading to total joint replacements. Estrogen is the primary female reproductive hormone. As a woman approaches menopause, estrogen production decreases by 100-fold. Previous research has shown that Estrogen Replacement Therapy (ERT) reduced joint replacements in post-menopausal women. However, there is a lack of research surrounding ERT's effect on chondrocyte proliferation and extracellular matrix production, particularly 3D culture extracellular matrix production. Chondrogenesis is a process of skeletal development resulting in the formation of cartilage. Chondrocytes, derived from mesenchymal progenitors, serve as the fundamental cellular component in …

The Relative Contribution Of Health-Care Points Of Service To Overall Patient Satisfaction At A University Health Center, Jay M. Parikh

Honors Undergraduate Theses

Throughout the process of receiving healthcare, a patient is affected by several factors and processes. To just name a few, how long a patient must wait at the clinic, how friendly the front desk is, how the nurse treats the patient, how effective the physician is with his or her communication, what the cost of a patient's healthcare is, and how clean the clinic is all affect the patient's experience. When clinics excel in these factors, it promotes a favorable relationship between the patient and the clinic. Patients trust the healthcare provider and desire to continue attending that clinic when …

Observing The Relationship Between Physical Activity, Overall Health, Anxiety, And Sleep, Brianna Chicas

Honors Undergraduate Theses

College students' mental health has been researched for some time. In particular, the correlation between physical activity and mental health symptoms has been researched. The study examines the relationship between physical activity and anxiety, sleep, and overall health. College undergraduate students at the University of Central Florida took an online survey that measured all of these variables. A Pearson's correlation coefficient was used to assess correlations. Positive correlations were found between anxiety and sleep, anxiety and social desirability, sleep and social desirability, and strength training and vigorous physical activity. Negative correlations were found between overall health and physical activity, overall …

Examining Academic Challenges And Mental Health Among First-Generation And Non-First-Generation Students, Cecilia Q. Bui

Honors Undergraduate Theses

First-generation students are individuals whose parents have not attended college. These students often face challenges such as academic pressures, lack of social support, and mental health problems. Research has found that first-generation students experience a culture shock when transitioning from high school to college. These factors can impact academic success and affect overall health. This quantitative, cross-sectional study examined the impact of stress on mental health among first-generation and non-first-generation students. The study also examined if social and emotional support had a buffering effect on levels of depression, anxiety, and academic stress among first-generation college students. A survey measuring these …

Characterization Of Multiphase Complex Coacervate Droplets, Lindsey Rush

Honors Undergraduate Theses

The intracellular environment of eukaryotic cells has been found to have membrane-less organelles, which form through liquid-liquid phase separation.^1,2 The membrane-less organelles within the cell can be modeled with multiphase complex coacervates that are formed through the combination of two liquid polyelectrolyte complex coacervates, which are individually made up of a pair of one positively charged polymer and one negatively charged polymer.^3,4 Membrane-less organelles in a eukaryotic cell have been found to aggregate from liquid to solid in neurological disorders and during the aging process⁵, and investigation into the factors affecting aggregation of multiphase complex coacervates …

The Effects Of Kangaroo Care On The Stress Levels Of Parents In The Nicu, Niyati Sishodia

Honors Undergraduate Theses

Background: Parents of NICU patients have high stress levels compared to other populations, which negatively impact their mental health. The kangaroo care (KC) method has been used for its numerous benefits for infants, but not as widely studied for its impacts on parental stress. The purpose of this integrative literature review is to examine and synthesize the existing evidence regarding kangaroo care and its impact on the stress levels of NICU parents.

Methods: A literature search was conducted utilizing CINAHL Plus with Full Text, MEDLINE, and APA PsychInfo databases to identify relevant articles. Articles were included if they were published …

Long Term Effects Analysis Of Children Exposed To Postpartum Depression, Asheria Foster

Honors Undergraduate Theses

The purpose of this study is to explore and understand any correlation between a mother having postpartum depression and her now college-level child having a mental illness. The research question posed for this study was: Is there a correlation between maternal postpartum depression and the development of mental illnesses in college students? Studies have shown that there is a correlation in early childhood development, but there are deficits when it comes to long-term follow-up. Data for this study was collected via online surveys on SONA UCF. The results from the Chi-square test imply a strong association (p = .007) at …

The Impact Of Telemedicine On Patient-Provider Communication At A University Student Health Center, Venkata Naga Sreelalitapriya Duvuuri

Honors Undergraduate Theses

Effective patient-provider communication (PPC) involves conveying sufficient information to a patient such that the treatment is agreed upon and implemented accurately. Furthermore, a patient must feel adequately involved in the treatment process. With the advent of the COVID-19 pandemic, many clinical visits were shifted online. Although telemedicine was successful in meeting pandemic-specific goals, such as lowering personal contact, it changes the communicative context. Both patients and providers get less input from body language (nonverbal communication) and rely more on verbal communication. Furthermore, the number of telemedicine visits conducted remains elevated over pre-pandemic levels. Much of what is known about effective …

Evaluation Of Sleep Benefits Following A 16-Week Judo Program For Children With Autism Spectrum Disorder, Neha R. Chittaluru

Honors Undergraduate Theses

Autism Spectrum Disorder is a neurodevelopmental disorder characterized by language and communication deficits, and difficulties with social interaction (Twisk, 2001). Research has shown that 80% of youth with ASD experience sleep challenges which can lead to sleep-related health issues, exacerbate problematic behaviors, and increase vulnerability to anxiety and depression (Wachob & Lorenzi, 2015; Williams et al., 2004; Richdale & Schreck, 2009). Sleep plays a central role in adaptive functioning, and insufficient sleep can hinder learning, memory, and neuroplasticity for children with ASD (Cohen et al., 2014). As these unhealthy behavior patterns can lead to more adverse long-term health consequences, it …

The Encapsulation Of Enzymes In Multiphase Complex Coacervates, Akash R. Rajaram

Honors Undergraduate Theses

Polyelectrolyte complex coacervates (PECCs) result from liquid-liquid phase separation (LLPS) in solutions containing oppositely charged polymers ¹. Multiphase polyelectrolyte complex coacervates (MPECCs) result from the combination of multiple, specific PECCs ². The encapsulation of proteins in PECCs can serve as promising vehicles for the effective delivery of protein-based therapeutics, which are notoriously difficult to deliver. The encapsulation of model proteins, such as Bovine Serum Albumin (BSA) ³ or Human Hemoglobin (Hb) ⁴ have illustrated the protein-encapsulating capabilities of these PECC systems. The encapsulation of proteins in MPECCs is a topic that has yet to be explored; however, it …

Role Of Endoplasmic Reticulum Stress Response In Parainfluenza Virus Acute To Persistent Infections, Lauren L. Abbitt

Honors Undergraduate Theses

Persistent viral infections are a major health concern, with persistently infected (PI) cells being a source of continued shedding of virus and generation of viral mutants. Here, we hypothesized that cells persistently infected with the enveloped virus parainfluenza virus 5 (PIV5) would show altered expression of endoplasmic reticulum (ER) stress proteins and increased resistance to death caused by drug-induced ER stress. To test this, lysates of mock-infected, PIV5 acute-infected, and PIV5 PI human lung A549 cells were collected and levels of ER stress proteins were compared. Western blotting revealed that immunoglobulin heavy chain binding protein (BiP/GRP78) was present in higher …