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Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
An Approach To Collect Non-Standard Microdialysis Compounds, Allison M. Schneider
An Approach To Collect Non-Standard Microdialysis Compounds, Allison M. Schneider
Chemistry & Biochemistry Undergraduate Honors Theses
Microdialysis is a sampling technique that is used to collect analytes through a semipermeable membrane. The collection occurs via the microdialysis probe where analytes can diffuse through the membrane and be collected by use of the outlet. Microdialysis is typically utilized with solutes that are hydrophilic and have a low molecular weight. It is unusual for hydrophobic solutes to be used, but pentane, a hydrophobic analyte, was studied in this research to see if non-standard microdialysis compounds can be collected. This is important because the pentane resembles hydrophobic signaling molecules in the brain, such as prostaglandins and leukotrienes and can …
Engineering A Mutation In The Heparin Binding Pocket Of The Human Fibroblast Growth Factor, Roshni Patel
Engineering A Mutation In The Heparin Binding Pocket Of The Human Fibroblast Growth Factor, Roshni Patel
Chemistry & Biochemistry Undergraduate Honors Theses
Fibroblast growth factors (FGFs) are family of proteins that belong to a group of growth factors that are found in mammals and play an important role in angiogenesis, differentiation, organogenesis, and tissue repair. In summary, their main functionality is involved in cell division and proliferation. Because FGFs plays such a vital role in cell proliferation, they are mainly involved in the process of wound healing and injuries. FGF binds to its ligand, heparin—a heavily sulfated glycosaminoglycan. The binding of heparin to FGF occurs through electrostatic interactions, specifically between the negatively charged sulfate groups on heparin and positively charged residues such …
Deciphering The Role Of Glycine134 In The Human Acidic Growth Factor-1’S Binding To Heparin, Adam W. Burroughs
Deciphering The Role Of Glycine134 In The Human Acidic Growth Factor-1’S Binding To Heparin, Adam W. Burroughs
Chemistry & Biochemistry Undergraduate Honors Theses
Human acidic fibroblast growth factor 1 (FGF-1) is a potent modulator of cell survival and exhibits a universal role in various physiological processes. Though potent, FGF-1 unbound to heparin is known to show a poor thermal stability and a relatively short in vivo half-life. Much is known about the structure and relation of FGF-1 with heparin yet there is still unknown information regarding the exact role of heparin in stabilizing FGF-1. Thus, the aim of this study is to mutate glycine at position 134 to glutamic acid in wild type FGF1. G134 is located in the heparin binding pocket, thus …