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Full-Text Articles in Medicine and Health Sciences
A Functional Analysis Of The Human Immunodeficiency Virus, Sushma Jyotika Bhakta
A Functional Analysis Of The Human Immunodeficiency Virus, Sushma Jyotika Bhakta
All ETDs from UAB
The retroviral life cycle is separated into two distinct phases of infection. In the first phase, viral enzymes and proteins allow the virus to establish infection. The virus usurps host machinery in the second stage to produce infectious virus. In both phases of the replication cycle, the envelope (Env) glycoprotein (gp) is a key component of infectivity. Env plays a pivotal role in viral entry, by mediating attachment and facilitating fusion of the viral and cellular membranes, and during assembly, where Env must be incorporated into budding virions in order to produce infectious virions. The Env cytoplasmic domain (CD) interacts …
Mechanisms Of Growth Hormone Action In Skeletal Muscle, Mahendra Devaraj Mavalli
Mechanisms Of Growth Hormone Action In Skeletal Muscle, Mahendra Devaraj Mavalli
All ETDs from UAB
Growth hormone (GH) and insulin like growth factor-1 (IGF-1) exert profound growth promoting actions during pre and postnatal skeletal muscle development. GH and IGF-1 seem to promote their anabolic actions by influencing skeletal muscle cell prolif-eration and fusion. However, because GH stimulates the production of IGF-1 from the liver and other GH-responsive peripheral tissues, including skeletal muscle, the individual contributions of these two growth factors to anabolic responses in skeletal muscle remains poorly defined. In this dissertation research, I sought to distinguish the mechanisms responsible for growth hormone's (GH) anabolic actions in skeletal muscle. To accomplish this, I analyzed the …