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Full-Text Articles in Medicine and Health Sciences
Characterization Of The Lining Epithelium Of Normal And Precancerous Uterine Cervix In Mice, Reem Mamoun Shouk
Characterization Of The Lining Epithelium Of Normal And Precancerous Uterine Cervix In Mice, Reem Mamoun Shouk
Dissertations
Despite the fact that cervical cancer is a common health issue among women worldwide, little is known regarding the epithelial lining of the uterine cervix where cancer originates. Cancer development involves alterations in carbohydrate expression and changes in the dynamics of cellular proliferation and differentiation. Therefore, the aim of this study was to define carbohydrate moieties and cellular dynamics of the epithelial lining of the uterine cervix in normal mice and then in mice developing cervical precancerous lesions. Since the uterus undergoes cyclic changes, mice in each of the four stages of the estrus cycle were first identified using both …
Establishment Of Organoids From Gastric Stem Cells And Their Use To Study The Role Of Aryl-Hydrocarbon Receptors, Shakila Afroz Taleb
Establishment Of Organoids From Gastric Stem Cells And Their Use To Study The Role Of Aryl-Hydrocarbon Receptors, Shakila Afroz Taleb
Dissertations
Stem cells are powerful tools in different aspects of biomedical and translational research, including disease modelling, drug testing, and tissue engineering for regenerative medicine. However, isolation and culture of organ-specific stem cells are challenging tasks. Therefore, the biological features of many adult stem cells are not well studied and their involvement in the development of cancer is still controversial. Some immortal stem cell lines have been established and used as an alternative to studying features of organ-specific stem cells. The ability to grow cells in a scaffold-free, three-dimensional (3D) model system that mimics in vivo conditions would help in revealing …
Establishment Of A 3d Culture Model Of Gastric Stem Cells Supporting Their Differentiation Into Mucous Cells Using Microfibrous Polycaprolactone Scaffold, Sunitha Pulikkot
Establishment Of A 3d Culture Model Of Gastric Stem Cells Supporting Their Differentiation Into Mucous Cells Using Microfibrous Polycaprolactone Scaffold, Sunitha Pulikkot
Dissertations
In the stomach, epithelial stem cells are responsible for glandular homeostasis and continuous production of four main cell lineages secreting mucus, acid, pepsinogen and hormones. While alteration in the proliferation and differentiation program of these stem cells is linked to the origin of gastric cancer, they represent an effective target for chemotherapy and a source for cell therapy or tissue engineering in cases of gastric mucosal damage or loss. The aims of this study were 1) to manufacture various forms of scaffolds using a biodegradable polymer (polycaprolactone), 2) to test the suitability of these scaffolds for growth of mouse gastric …