Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Biochemical Phenomena, Metabolism, and Nutrition (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Chemicals and Drugs (1)
- Cognitive Neuroscience (1)
-
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1)
- Diseases (1)
- Endocrine System Diseases (1)
- Endocrinology (1)
- Endocrinology, Diabetes, and Metabolism (1)
- Gastroenterology (1)
- Health and Medical Administration (1)
- Hormones, Hormone Substitutes, and Hormone Antagonists (1)
- Life Sciences (1)
- Medical Sciences (1)
- Medical Specialties (1)
- Medicinal Chemistry and Pharmaceutics (1)
- Molecular and Cellular Neuroscience (1)
- Neuroscience and Neurobiology (1)
- Neurosciences (1)
- Other Neuroscience and Neurobiology (1)
- Other Pharmacology, Toxicology and Environmental Health (1)
- Other Physiology (1)
- Pharmacology (1)
- Pharmacology, Toxicology and Environmental Health (1)
- Physiology (1)
- Preventive Medicine (1)
- Psychiatry (1)
- Quality Improvement (1)
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Cortisol Receptor Sensitivity As A Risk Factor For Depression, Michela Michielli
Cortisol Receptor Sensitivity As A Risk Factor For Depression, Michela Michielli
Honors Theses
In 2020, the World Health Organization reported over 264 million people across the world were suffering from depression. Studies have demonstrated that one source of depression is a hormonal imbalance involved in the stress response. Cortisol is a stress hormone regulated by the Hypothalamic-Anterior-Pituitary (HPA) Axis. Its effects on the stress response and other metabolic activities in the body are exerted through the glucocorticoid and mineralocorticoid receptors (GR and MR respectively).
Our research has examined mutations known as single-nucleotide-polymorphisms (SNPs) relating to cortisol-receptor sensitivity and the behavior of cortisol in the body to investigate the link between cortisol activity and …
The Impact Of Single Nucleotide Polymorphisms On Cortisol Receptor Activity In Populations With Obesity, Cassidy Michalicka
The Impact Of Single Nucleotide Polymorphisms On Cortisol Receptor Activity In Populations With Obesity, Cassidy Michalicka
Honors Theses
Cortisol is a crucial part of the endocrine system; it has the capacity to affect nearly every organ and tissue in the human body. When functioning correctly, cortisol is known to regulate the body’s stress response, control metabolism, suppress inflammation, regulate blood pressure, regulate blood sugar, regulate our body’s circadian rhythm, and much more. When the concentration of cortisol in the blood is elevated for an excessive period, the body responds with symptoms such as hyperglycemia, hypertension, weight gain, and moon face. Commonly this is known as Cushing’s Syndrome (CS), and interestingly, we have seen a phenotypic resemblance when contrasted …