Medicine and Health Sciences Commons^™

Heterologous Expression Of Babesia Microti Secreted Antigen (Bmsa1) In A Pichia Pastoris Expression System For The Development Of An Antigen Specific Elisa, Anthony Centone

NYMC Student Theses and Dissertations

Babesia microti is a tick born, intraerythrocytic parasite that is endemic to many North American regions. B. microti infection causes a disease called babesiosis, a disease whose clinical manifestation causes a wide range of symptoms, from asymptomatic infection to fulminant disease and possible death. Transfusion transmitted babesiosis is becoming an increasing concern as B. microti prevalence continues to grow and donor screening methods are ineffective. Transfusion transmitted babesiosis can be extremely dangerous, with as many as one in five cases resulting in death. Babesia microti secreted antigen (BmSA1) is an immunogen and reliable biomarker for B. microti infection. The aim …