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Full-Text Articles in Medicine and Health Sciences
The Impact Of Chronic Morphine Exposure On The Intrinsic Electrical Properties Of Orexin Neurons, Elizabeth Berry
The Impact Of Chronic Morphine Exposure On The Intrinsic Electrical Properties Of Orexin Neurons, Elizabeth Berry
NYMC Student Theses and Dissertations
Addiction to drugs of abuse is a growing problem in today’s society and current treatments often fail to adequately manage the negative withdrawal symptoms that drive relapse. Therefore, development of more effective therapies is a high priority. The orexin neuropeptide system is a key regulator of reward processes and is therefore an attractive therapeutic target. However, the precise impact of chronic drug exposure on orexin neuron function remains largely unknown. Data from a recent publication found that human post-mortem brains from opiate users have smaller but more numerous orexin immunoreactive neurons. Since decreased neuronal soma area suggests increased excitability, we …
Ion Channel Candidates Mediating Orexin Neuropeptide Actions On Brainstem Serotonergic Neurons, Saqlain Javed
Ion Channel Candidates Mediating Orexin Neuropeptide Actions On Brainstem Serotonergic Neurons, Saqlain Javed
NYMC Student Theses and Dissertations
A loss of neurons that synthesize the neuropeptide orexin produces the sleep disorder narcolepsy with cataplexy in humans and other animals. How symptoms of this disorder arise is not well understood, but selectively restoring orexin actions at 5-HT DR neurons rescues key symptoms (cataplexy), suggesting normal orexin signaling is important at these neurons. To better understand how orexin acts on these neurons, our lab identified a set of novel orexin actions that appear mediated by unidentified cation- permeable ion channels. To narrow down the list of possible channels, we used a bioinformatics approach to compare published gene expression profiles of …