Medicine and Health Sciences Commons^™

Novel Anti-Influenza Monoclonal Antibodies, Ozlem Gurses

NYMC Student Theses and Dissertations

There is a continual public threat of influenza virus infections. This is related to viruses evolving in multiple animal reservoirs, making infection prevention in humans difficult to achieve and leading to seasonal epidemics and the semi-regular emergence of pandemics. Novel antibody-based therapies are of great interest to researchers because of a dramatic increase in drug resistant strains of influenza viruses. The identification of cross-reactive and broadly protective monoclonal antibodies targeting the influenza proteins presents a promising prospect for the development of a universal therapy. Although the research related to the monoclonal antibodies targeting the viral internal proteins is limited, multiple …

Planners Vs. Non-Planners: Do Preterm Births Impact Future Contraceptive Use?, Jessie Moore

NYMC Student Theses and Dissertations

Background: In the United States, 45% of all pregnancies are unintended and occur when contraception is not used or is used inconsistently. Among those pregnancies, 1 in 10 women will experience a preterm birth, which is defined as a birth occurring before 37 weeks gestation. Women who have delivered preterm are at an increased risk for preterm birth in future pregnancies and are encouraged to wait at least 18 months between giving birth and getting pregnant again. Among women who have experienced a preterm birth, the desire to delay future pregnancy or avoiding it all together often becomes a necessity …

Socio-Economic Determinants Of Gender-Based Violence [Gbv]: Sdg Analytics On The Global Gbv Scenario With Special Reference To Technology Facilitated Gender-Based Violence And Adolescent Birth Rates, Chandra P. Daniel

NYMC Student Theses and Dissertations

Gender-based violence (GBV) is a multifaceted problem. The most rapidly increasing modern form of violence is the intertwined epidemic of ‘Technology Facilitated GBV’ [TF GBV] and sexual violence against women and girls. It was critical to investigate the global impact of this epidemic during COVID-19 since a disproportionate impact of violence was observed among women and girls in low and middle-income countries. A retrospective cross-sectional research design was adopted using linear regression analysis (univariate and multivariate) on SDG 5.2, a set of global indicators, to elicit the socioeconomic determinants of GBV. Phase-I results exposed the top-four socio-economic determinants …

Novel Natural Compounds Derived From Tcm In The Treatment Of Food Induced Anaphylaxis, Ibrahim Musa

NYMC Student Theses and Dissertations

Food allergy is a highly prevalent disease affecting about 30 million people in the U.S. It is managed primarily by food avoidance due to lack of promising treatment options. ASHMI (anti-asthma herbal intervention) which consists of three components, Sophorae flavescentis, Ganoderma lucidum, Glycyrrhiza uralensis has been shown to inhibit allergic lung inflammation in antigen sensitized and challenged mice. In this study we isolate and identify the active compound in Sophorae flavescentis, characterized the mechanism of IgE inhibitory effect, biomarkers and potential to prevent food anaphylaxis.

To separate and identify the compounds we used column chromatography, high-performance liquid chromatography, mass …

Shifting Gears: - The Expected Post-Transplant Survival (Epts) Usefulness In The Era Of Continuous Distribution- Examination Of The United Network Of Organ Sharing (Unos) Database 2000-2020, Vaughn Whittaker, Vaughn Easton Whittaker

NYMC Student Theses and Dissertations

The allocation of organs is a constantly evolving area of transplantation. The latest iteration of this process is a move toward continuous distribution of organs. This process considers dynamic factors instead of static constraints that box patients into certain categories. The expected post-transplant survival of patients is one of these dynamic factors that will be included in the assessment of patients' place in a continuous distribution allocation process. However, the predictive value of this construct is questionable, given that it uses only four factors (age, diabetes diagnosis, years on dialysis, and previous transplant) to represent complex patients who are on …

Gpr75 Deficiency Attenuates High Fat Diet-Driven Obesity And Glucose Intolerance, Sakib Hossain

NYMC Student Theses and Dissertations

Recently, a collaboration between Regeneron Pharmaceuticals and the Schwartzman-Garcia labs at New York Medical College published an exome sequencing study of individuals across the United Kingdom, United States, and Mexico which concluded that individuals possessing non-functioning, truncated mutations to the orphan g protein coupled receptor (GPCR), GPR75, had lower BMI and 54% reduced likelihood of obesity. The present study was undertaken to fully characterize the metabolic phenotype of Gpr75 deficient mice when fed a high fat diet (HFD) and explore potential mechanisms by which GPR75 activation links to increased adiposity and decreased glucose tolerance. After 14 weeks of HFD-feeding we …

The Impact Of Chronic Morphine Exposure On The Intrinsic Electrical Properties Of Orexin Neurons, Elizabeth Berry

NYMC Student Theses and Dissertations

Addiction to drugs of abuse is a growing problem in today’s society and current treatments often fail to adequately manage the negative withdrawal symptoms that drive relapse. Therefore, development of more effective therapies is a high priority. The orexin neuropeptide system is a key regulator of reward processes and is therefore an attractive therapeutic target. However, the precise impact of chronic drug exposure on orexin neuron function remains largely unknown. Data from a recent publication found that human post-mortem brains from opiate users have smaller but more numerous orexin immunoreactive neurons. Since decreased neuronal soma area suggests increased excitability, we …

Prevalence, Trends, And Predictors Of Domestic Violence Among Nigerian Women; An Analysis Using 2008, 2013 And 2018 Waves Of The Nigeria Demographic Health Survey (Ndhs), Nkemdilim Chukwueme

NYMC Student Theses and Dissertations

Domestic violence (abbreviated DV for this study) among women in African settings is often considered a ‘family matter’ and requires limited external interference. This study aims to identify the national and regional prevalence, trend in prevalence rates, influencing factors in predicting domestic violence among Nigerian women, victims’ response in seeking help, and potential victim-centered digital solutions to addressing domestic violence. In Nigeria, little has been done to assess; a nationally representative prevalence of DV among Nigerian women in the last decade to see if there are changing trends in prevalence; extensively investigate the influence of socio-demographic factors in predicting DV …

Positive Parenting With Guyanese Children, Parthener Pinder

NYMC Student Theses and Dissertations

During the earliest years of life, a child has rapid neurological development. In low- and middle-income countries (LMICs), such as Guyana, there continues to be a struggle to educate all children, especially those in rural or isolated areas leading to concerns about young children's development, particularly those under five. LMICs have little research on how caregiver positive parenting in the household affects early childhood development as well as how other sociodemographic factors influence positive parenting. This study answers the question: Does positive parenting in the household improve learning development in Guyanese children? This study used Guyana’s Multiple Indicator Cluster Survey …