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Full-Text Articles in Medicine and Health Sciences
Enzymatic Depletion Of Mitochondrial Inorganic Polyphosphate (Polyp) Increases The Generation Of Reactive Oxygen Species (Ros) And The Activity Of The Pentose Phosphate Pathway (Ppp) In Mammalian Cells, Vedangi Hambardikar, Mariona Guitart-Mampel, Ernest Scoma, Pedro Urquiza, Gowda Nagana, Daniel Raftery, John Collins, Maria Solesio
Enzymatic Depletion Of Mitochondrial Inorganic Polyphosphate (Polyp) Increases The Generation Of Reactive Oxygen Species (Ros) And The Activity Of The Pentose Phosphate Pathway (Ppp) In Mammalian Cells, Vedangi Hambardikar, Mariona Guitart-Mampel, Ernest Scoma, Pedro Urquiza, Gowda Nagana, Daniel Raftery, John Collins, Maria Solesio
Department of Orthopaedic Surgery Faculty Papers
Inorganic polyphosphate (polyP) is an ancient biopolymer that is well preserved throughout evolution and present in all studied organisms. In mammals, it shows a high co-localization with mitochondria, and it has been demonstrated to be involved in the homeostasis of key processes within the organelle, including mitochondrial bioenergetics. However, the exact extent of the effects of polyP on the regulation of cellular bioenergetics, as well as the mechanisms explaining these effects, still remain poorly understood. Here, using HEK293 mammalian cells under Wild-type (Wt) and MitoPPX (cells enzymatically depleted of mitochondrial polyP) conditions, we show that depletion of polyP within mitochondria …