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Association Between Baseline Diastolic Blood Pressure And The Efficacy Of Intensive Vs Standard Blood Pressure-Lowering Therapy, Andrew J Foy, Edward J Filippone, Eric Schaefer, Matt Nudy, Mohammed Ruzieh, Anne-Marie Dyer, Vernon M Chinchilli, Gerald V Naccarelli
Association Between Baseline Diastolic Blood Pressure And The Efficacy Of Intensive Vs Standard Blood Pressure-Lowering Therapy, Andrew J Foy, Edward J Filippone, Eric Schaefer, Matt Nudy, Mohammed Ruzieh, Anne-Marie Dyer, Vernon M Chinchilli, Gerald V Naccarelli
Department of Medicine Faculty Papers
Importance: Low diastolic blood pressure (DBP) has been found to be associated with increased adverse cardiovascular events; however, it is unknown whether intensifying blood pressure therapy in patients with an already low DBP to achieve a lower systolic blood pressure (SBP) target is safe or effective.
Objective: To evaluate whether there is an association of baseline DBP and intensification of blood pressure-lowering therapy with the outcomes of all-cause death and cardiovascular events.
Design, setting, and participants: This cohort study analyzed patients who were randomized to intensive or standard BP control in the Action to Control Cardiovascular Risk in Diabetes-Blood Pressure …