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Full-Text Articles in Medicine and Health Sciences
Acetylation Of The Cell-Fate Factor Dachshund Determines P53 Binding And Signaling Modules In Breast Cancer., Ke Chen, Kongming Wu, Michael Gormley, Adam Ertel, Jing Wang, Wei Zhang, Jie Zhou, Gabriele Disante, Zhiping Li, Hallgeir Rui, Andrew A Quong, Steven B Mcmahon, Haiteng Deng, Michael P Lisanti, Chenguang Wang, Richard G Pestell
Acetylation Of The Cell-Fate Factor Dachshund Determines P53 Binding And Signaling Modules In Breast Cancer., Ke Chen, Kongming Wu, Michael Gormley, Adam Ertel, Jing Wang, Wei Zhang, Jie Zhou, Gabriele Disante, Zhiping Li, Hallgeir Rui, Andrew A Quong, Steven B Mcmahon, Haiteng Deng, Michael P Lisanti, Chenguang Wang, Richard G Pestell
Department of Cancer Biology Faculty Papers
Breast cancer is a leading form of cancer in the world. The Drosophila Dac gene was cloned as an inhibitor of the hyperactive epidermal growth factor (EGFR), ellipse. Herein, endogenous DACH1 co-localized with p53 in a nuclear, extranucleolar compartment and bound to p53 in human breast cancer cell lines, p53 and DACH1 bound common genes in Chip-Seq. Full inhibition of breast cancer contact-independent growth by DACH1 required p53. The p53 breast cancer mutants R248Q and R273H, evaded DACH1 binding. DACH1 phosphorylation at serine residue (S439) inhibited p53 binding and phosphorylation at p53 amino-terminal sites (S15, S20) enhanced DACH1 binding. DACH1 …