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Department of Cancer Biology Faculty Papers
A TH1 immune response efficiently clears rabies virus from the CNS in the absence of inflammation
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A Th1 Immune Response Efficiently Clears Rabies Virus From The Cns In The Absence Of Inflammation, Aurore Lebrun, Rhonda Kean, Jianwei Li, Douglas Craig Hooper
A Th1 Immune Response Efficiently Clears Rabies Virus From The Cns In The Absence Of Inflammation, Aurore Lebrun, Rhonda Kean, Jianwei Li, Douglas Craig Hooper
Department of Cancer Biology Faculty Papers
Little is known about CD4+ T cell entry into the central nervous system (CNS) in the absence of inflammation. Attenuated rabies viruses (RABV) are unique tools to study this process, as they spread from the site of inoculation to the CNS trans-axonally, without compromising the blood-brain barrier. Previous studies with live-attenuated RABV showed that CD4+ T cell entry into the CNS is associated with an increase in IFN-g mRNA in the brain and the production of IgG2a antibodies in the periphery, indicating a bias towards TH1 immunity. To further investigate the nature of the CD4+ T cells involved in the …