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Markers Of Elevated Left Ventricular Filling Pressure Are Associated With Increased Mortality In Nonsevere Aortic Stenosis, Lauren C. Giudicatti, Sally Burrows, David Playford, Geoff Strange, Graham Hillis

Medical Papers and Journal Articles

Background: Echocardiographic measures of elevated left ventricular filling pressures are associated with an adverse prognosis. The aim of this study was to determine the relationship between acute (ratio of early transmitral flow to mitral annular velocities; E/e’) and chronic (indexed left atrial volume; LAVI) markers of left ventricular filling pressure (LVFP) and mortality in patients with non-severe aortic stenosis (AS), within the National Echo Database of Australia cohort. We hypothesised that they would reflect the early haemodynamic consequences of AS and be associated with increased mortality in this setting.

Methods: The first record for patients 18 years or over showing …

Ejection Fraction And Mortality: A Nationwide Register-Based Cohort Study Of 499 153 Women And Men, Simon Stewart, David Playford, Gregory M. Scalia, Philip Currie, David S. Celermajer, David Prior, Jim Codde, Geoff Strange

Medical Papers and Journal Articles

Aims: We investigated the sex-based risk of mortality across the spectrum of left ventricular ejection fraction (LVEF) in a large cohort of patients in Australia.

Methods and results: Quantified levels of LVEF from 237 046 women (48.1%) and 256 109 men undergoing first-time, routine echocardiography (2000–2019) were linked to 119 232 deaths (median 5.6 years of follow-up). Overall, 17.6% of men vs. 8.3% of women had an LVEF P< 0.001] in women and 1.21 (95% CI 1.05–1.39; P = 0.008) in men. In women, an LVEF of 60.0–64.9% was also associated with a HR 1.33 (95% CI 1.16–1.52; P< 0.001) for cardiovascular-related mortality. These associations were most striking in women and men aged

Conclusions: Among patients investigated for suspected or established cardiovascular …