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Full-Text Articles in Medicine and Health Sciences
Genetic And Cellular Studies Highlight That A Disintegrin And Metalloproteinase 19 Is A Protective Biomarker In Human Prostate Cancer, Gerard F. Hoyne, Caoline Rudnicka, Qing-Xiang Sang, Mark Roycik, Sarah Howarth, Peter Leedman, Markus Schlaich, Patrick Candy, Vance Matthews
Genetic And Cellular Studies Highlight That A Disintegrin And Metalloproteinase 19 Is A Protective Biomarker In Human Prostate Cancer, Gerard F. Hoyne, Caoline Rudnicka, Qing-Xiang Sang, Mark Roycik, Sarah Howarth, Peter Leedman, Markus Schlaich, Patrick Candy, Vance Matthews
Health Sciences Papers and Journal Articles
Background: Prostate cancer is the second most frequently diagnosed cancer in men worldwide. Current treatments include surgery, androgen ablation and radiation. Introduction of more targeted therapies in prostate cancer, based on a detailed knowledge of the signalling pathways, aims to reduce side effects, leading to better clinical outcomes for the patient. ADAM19 (A Disintegrin And Metalloproteinase 19) is a transmembrane and soluble protein which can regulate cell phenotype through cell adhesion and proteolysis. ADAM19 has been positively associated with numerous diseases, but has not been shown to be a tumor suppressor in the pathogenesis of any human cancers. Our group …
Overexpression And Knock-Down Studies Highlight That A Disintegrin And Metalloproteinase 28 Controls Proliferation And Migration In Human Prostate Cancer, C Rudnicka, S Mochizuki, Y Okada, C Mclaughlin, P Leedman, L Stuart, M Epis, G Hoyne, S Boulos, L Johnson, M Schlaich, V Matthews
Overexpression And Knock-Down Studies Highlight That A Disintegrin And Metalloproteinase 28 Controls Proliferation And Migration In Human Prostate Cancer, C Rudnicka, S Mochizuki, Y Okada, C Mclaughlin, P Leedman, L Stuart, M Epis, G Hoyne, S Boulos, L Johnson, M Schlaich, V Matthews
Medical Papers and Journal Articles
Prostate cancer is one of the most prevalent cancers inmen. It is critical to identify and characterize oncogenes that drive the pathogenesis of human prostate cancer. The current study builds upon previous research showing that a disintegrin and metalloproteinase (ADAM)28 is involved in the pathogenesis of numerous cancers. Our novel study used overexpression, pharmacological, and molecular approaches to investigate the biological function of ADAM28 in human prostate cancer cells,with a focus on cell proliferation andmigration. The results of this study provide important insights into the role of metalloproteinases in human prostate cancer.
The expression of ADAM28 protein levels was assessed …