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The Regulation Of Hpv Late Gene Expression And The Potential Role Of Inkt Cells In Cervical Cancer, Patrice Nolan
The Regulation Of Hpv Late Gene Expression And The Potential Role Of Inkt Cells In Cervical Cancer, Patrice Nolan
Masters
Human papillomaviruses (HPVs) are ubiquitous, sexually transmitted viruses present in 99.7% of all cervical cancers, the second most common cancer in females worldwide. Expression of HPV L1 and L2 late genes is found only in terminally differentiated epithelial cells. As L1 and L2 proteins are highly immunogenic, it is suggested that their suppression may prevent detection of the virus by the immune system, thus acting as a prerequisite for persistence of infection. Therefore, if expression of these proteins in the lower cervical layers was induced, it could lead to clearance of the virus. One aim of this thesis was to …