Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Optometry (8)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (6)
- Life Sciences (4)
- Physical Sciences and Mathematics (4)
- Chemicals and Drugs (3)
-
- Medical Sciences (3)
- Analytical Chemistry (2)
- Chemistry (2)
- Diagnosis (2)
- Food Chemistry (2)
- Food Science (2)
- Genetics (2)
- Genetics and Genomics (2)
- Laboratory and Basic Science Research (2)
- Medical Specialties (2)
- Nursing (2)
- Other Analytical, Diagnostic and Therapeutic Techniques and Equipment (2)
- Public Health (2)
- Amino Acids, Peptides, and Proteins (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Bioinformatics (1)
- Biomedical (1)
- Biomedical Engineering and Bioengineering (1)
- Chemical and Pharmacologic Phenomena (1)
- Community Health and Preventive Medicine (1)
- Computer Sciences (1)
- Diseases (1)
- Electrical and Computer Engineering (1)
- Keyword
-
- Age-related macular degeneration (4)
- Alzheimer disease (2)
- European Youth Heart Study (2)
- Infant feeding (2)
- Infant nutrition (2)
-
- Ireland (2)
- Lc-ms/ms (2)
- Macular pigment (2)
- Nutrition (2)
- Phacoemulsification (2)
- Validation (2)
- Adolescents (1)
- Alpha-secretase (1)
- Alzheimer Disease (1)
- Anisotropic Diffusion (1)
- Anterior chamber angle (1)
- Anterior chamber depth (1)
- Anterior chamber volume (1)
- Antibiotics (1)
- Antigens (1)
- Astigmatism (1)
- Automated tracking (1)
- Beta-secretase (1)
- Biomarker (1)
- Brain cholesterol (1)
- Breastfeeding determinants (1)
- Breastfeeding duration (1)
- Breastfeeding practices (1)
- Breastfeeding rates (1)
- CYP46A1 (1)
Articles 1 - 30 of 33
Full-Text Articles in Medicine and Health Sciences
Development And Validation Of A Rapid Multi-Class Method For The Confirmation Of Fourteen Prohibited Medicinal Additives In Pig And Poultry Compound Feed By Liquid Chromatography Tandem Mass Spectrometry, Mark Cronly, Patrice Behan, Barry Foley, Liam Regan, Marella Gallagher, Sean Earley, Paula Shearan, Edward Malone
Development And Validation Of A Rapid Multi-Class Method For The Confirmation Of Fourteen Prohibited Medicinal Additives In Pig And Poultry Compound Feed By Liquid Chromatography Tandem Mass Spectrometry, Mark Cronly, Patrice Behan, Barry Foley, Liam Regan, Marella Gallagher, Sean Earley, Paula Shearan, Edward Malone
Articles
A confirmatory method has been developed to allow for the analysis of fourteen prohibited medicinal additives in pig and poultry compound feed. These compounds are prohibited for use as feed additives although some are still authorised for use in medicated feed. Feed samples are extracted by acetonitrile with addition of sodium sulphate. The extracts undergo a hexane wash to aid with sample purification. The extracts are then evaporated to dryness and reconstituted in initial mobile phase. The samples undergo an ultracentrifugation step prior to injection onto the LC-MS/MS system and are analysed in a run time of 26 minutes. The …
A Monocular Marker-Free Gait Measurement System, Jane Courtney, Annraoi M. De Paor
A Monocular Marker-Free Gait Measurement System, Jane Courtney, Annraoi M. De Paor
Articles
This paper presents a new, user-friendly, portable motion capture and gait analysis system for capturing and analyzing human gait, designed as a telemedicine tool to monitor remotely the progress of patients through treatment. The system requires minimal user input and simple single-camera filming (which can be acquired from a basic webcam) making it very accessible to nontechnical, nonclinical personnel. This system can allow gait studies to acquire a much larger data set and allow trained gait analysts to focus their skills on the interpretation phase of gait analysis. The design uses a novel motion capture method derived from spatiotemporal segmentation …
Letter To The Editor, Charlotte Johnston Molloy, Clare Corish, John Kearney, Noirin Hayes, Corina Glennon Slattery
Letter To The Editor, Charlotte Johnston Molloy, Clare Corish, John Kearney, Noirin Hayes, Corina Glennon Slattery
Articles
No abstract provided.
A Functional Polymorphism In The Hmgcr Promoter Affects Transcriptional Activity But Not The Risk For Alzheimer Disease In Swedish Populations., Lina Keller, Charlotte Murphy, Steve Meaney
A Functional Polymorphism In The Hmgcr Promoter Affects Transcriptional Activity But Not The Risk For Alzheimer Disease In Swedish Populations., Lina Keller, Charlotte Murphy, Steve Meaney
Articles
Variations in genes associated with cholesterol homeostasis have been reported to modify the risk of developing Alzheimer disease (AD). To date there have been few investigations into variations in genes directly involved in cholesterol biosynthesis and AD. We investigated the influence of the -911C>A polymorphism (rs3761740) in the hydroxy-methyl-glutaryl CoA reductase (HMGCR) gene promoter on basal and regulated transcription, plasma cholesterol levels and the association with AD. Under in vitro conditions the A allele was found to be significantly more responsive to SREBP-2 mediated regulation than the C allele. In an age and sex matched case-control study, the genotype …
Effect On Refractive Outcomes After Cataract Surgery Of Intraocular Lens Constant Personalization Using The Haigis Formula, Sofia Charalampidou, Lorraine Cassidy, Eugene Ng, James Loughman, John Nolan, Jim Stack, Stephen Beatty
Effect On Refractive Outcomes After Cataract Surgery Of Intraocular Lens Constant Personalization Using The Haigis Formula, Sofia Charalampidou, Lorraine Cassidy, Eugene Ng, James Loughman, John Nolan, Jim Stack, Stephen Beatty
Articles
Methods Personalization of Haigis IOL constants was performed using a series of 248 suitable eyes after biometry by partial coherence interferometry (IOLMaster) and IOL prediction based on optimized IOL constants derived from pooled data from the User Group for Laser Interference Biometry web site. A mean error of prediction and a mean absolute error were then calculated using the personalized IOL constants and compared with those derived using optimized IOL constants, allowing evaluation and quantification of the maximum realizable refractive benefits (if any) of personalization. Results There was no statistically significant difference between personalized and optimized Haigis IOL constants in …
Rapid Multi-Class Multi-Residue Method For The Confirmation Of Chloramphenicol And Eleven Nitroimidazoles In Milk And Honey By Liquid Chromatography Tandem Mass Spectrometry, Mark Cronly, Patrice Behan, Barry Foley, Liam Regan, Sheila Martin, Michael Doyle, Edward Malone
Rapid Multi-Class Multi-Residue Method For The Confirmation Of Chloramphenicol And Eleven Nitroimidazoles In Milk And Honey By Liquid Chromatography Tandem Mass Spectrometry, Mark Cronly, Patrice Behan, Barry Foley, Liam Regan, Sheila Martin, Michael Doyle, Edward Malone
Articles
A confirmatory method has been developed to allow for the analysis of eleven nitroimidazoles and also chloramphenicol in milk and honey samples. These compounds are classified as A6 compounds in annex IV of council regulation 2377/90 and therefore prohibited for the use in animal husbandry. Milk samples are extracted by acetonitrile with addition of NaCl, while honey samples are first dissolved in water before a similar extraction. Honey extracts undergo a hexane wash to remove impurities. Both milk and honey extracts are evaporated to dryness and reconstituted in initial mobile phase. These are then injected onto an LC-MS/MS system and …
Surgically Induced Astigmatism After Phacoemulsification With And Without Correction For Posture-Related Ocular Cyclotorsion, I. Dooley, S. Charalampidou, A. Malik, G. Ormonde, James Loughman, Laura Molloy, Stephen Beatty
Surgically Induced Astigmatism After Phacoemulsification With And Without Correction For Posture-Related Ocular Cyclotorsion, I. Dooley, S. Charalampidou, A. Malik, G. Ormonde, James Loughman, Laura Molloy, Stephen Beatty
Articles
Purpose To report the impact of posture-related ocular cyclotorsion on one surgeon's surgically induced astigmatism (SIA) results and the variance in SIA. Setting Institute of Eye Surgery, Whitfield Clinic, Waterford, Ireland. Methods This prospective randomized controlled study included eyes that had phacoemulsification with intraocular lens implantation. Eyes were randomly assigned to have (intervention group) or not have (control group) correction for posture-related ocular cyclotorsion. In the intervention group, the clear corneal incision was placed precisely at the 120-degree meridian with instruments designed to correct posture-related ocular cyclotorsion. In the control group, the surgeon endeavored to place the incision at the …
Augmentation Of Macular Pigment Following Supplementation With All Three Macular Carotenoids: An Exploratory Study, Eithne Connolly, Stephen Beatty, David Thurnham, James Loughman, Alan Howard, Jim Stack, John Nolan
Augmentation Of Macular Pigment Following Supplementation With All Three Macular Carotenoids: An Exploratory Study, Eithne Connolly, Stephen Beatty, David Thurnham, James Loughman, Alan Howard, Jim Stack, John Nolan
Articles
Purpose:At the macula, the carotenoids meso-zeaxanthin (MZ), lutein (L), and zeaxanthin (Z) are collectively referred to as macular pigment (MP). This study was designed to measure serum and macular responses to a macular carotenoid formulation. Materials and Methods:Ten subjects were recruited into this study (five normal and five with early age-related macular degeneration [AMD]). Subjects were instructed to consume a formulation containing 7.3mg of MZ, 3.7mg of L, and 0.8mg of Z everyday over an eight-week period. The spatial profile of MP optical density (i.e., MPOD at 0.25°, 0.5°, 1°, and 1.75°) was measured using customized heterochromatic flicker photometry, and …
The Relationship Between Macular Pigment And Visual Performance, James Loughman, Mukunda Akkali, Stephen Beatty, Grainne Scanlon, Peter Davison, Veronica O'Dwyer, Thomas Cantwell, Philip Major, Jim Stack, John Nolan
The Relationship Between Macular Pigment And Visual Performance, James Loughman, Mukunda Akkali, Stephen Beatty, Grainne Scanlon, Peter Davison, Veronica O'Dwyer, Thomas Cantwell, Philip Major, Jim Stack, John Nolan
Articles
This study was designed to assess whether macular pigment optical density (MPOD) is associated with visual performance. One hundred and forty-two young healthy subjects were recruited. Macular pigment optical density and visual performance were assessed by psychophysical tests including best corrected visual acuity (BCVA), mesopic and photopic contrast sensitivity, glare sensitivity, photostress recovery time (PRT). Measures of central visual function, including BCVA and contrast sensitivity, were positively associated with MPOD (p < 0.05, for all). Photostress recovery and glare sensitivity were unrelated to MPOD (p > 0.05). A longitudinal, placebo-controlled and randomized supplementation trial will be required to ascertain whether augmentation of MPOD can influence visual performance.
Fractional Anisotropic Diffusion For Noise Reduction In Magnetic Resonance Images, Jonathan Blackledge, Matthew Blackledge
Fractional Anisotropic Diffusion For Noise Reduction In Magnetic Resonance Images, Jonathan Blackledge, Matthew Blackledge
Articles
We extend the method of anisotropic diffusion for noise reduction in digital images to the case when the diffusion processes are non-Gaussian and Levy distributed. This yields a fractional diffusion equation characterised by the Levy index. A solution to this equation is considered and a numerical algorithm developed. The algorithm is then applied as a case study to the problem of reducing noise in magnetic resonance imaging. The focus of this study is on diffusion weighted images which have low signal-to-noise ratios.
Reactive Oxygen Species Induced Cytokine Production And Cytotoxicity Of Pamam Dendrimers In J774a.1 Cells, Pratap Naha, Maria Davoren, Fiona Lyng, Hugh Byrne
Reactive Oxygen Species Induced Cytokine Production And Cytotoxicity Of Pamam Dendrimers In J774a.1 Cells, Pratap Naha, Maria Davoren, Fiona Lyng, Hugh Byrne
Articles
The immunotoxicity of three generations of polyamidoamine (PAMAM) dendrimers (G-4, G-5 and G-6) was evaluated in mouse macrophage cells in vitro. Using the Alamar blue and MTT assays, a generation dependent cytotoxicity of the PAMAM dendrimers was found whereby G-6 > G-5 > G-4. The toxic response of the PAMAM dendrimers correlated well with the number of surface primary amino groups, with increasing number resulting in an increase in toxic response. An assessment of intracellular ROS generation by the PAMAM dendrimers was performed by measuring the increased fluorescence as a result of intracellular oxidation of Carboxy H2DCFDA to DCF both quantitatively using …
Macular Pigment Optical Density In An Aging Irish Population: The Irish Longitudinal Study On Ageing, John Nolan, Roseanne Kenny, Claire O'Regan, Hilary Cronin, James Loughman, Eithne Connolly, Patricia Kearney, Stephen Beatty
Macular Pigment Optical Density In An Aging Irish Population: The Irish Longitudinal Study On Ageing, John Nolan, Roseanne Kenny, Claire O'Regan, Hilary Cronin, James Loughman, Eithne Connolly, Patricia Kearney, Stephen Beatty
Articles
Purpose: The 3 carotenoids lutein, zeaxanthin, and meso-zeaxanthin, which account for the ‘yellow spot’ at the macula and which are referred to as macular pigment (MP), are believed to play a role in visual function and protect against age-related macular degeneration (AMD) via their optical and antioxidant properties. This study was undertaken to compare MP optical density (MPOD) in a population aged ≧50 years with MPOD values from a normative database of subjects aged 18–60 years. Methods: Seventy-nine subjects were recruited into this pilot study (The Irish Longitudinal Study on Ageing-TILDA). MPOD was measured using heterochromatic flicker photometry. Retinal fundus …
Macular Pigment And Its Contribution To Visual Performance And Experience [El Pigmento Macular Y Su Contribución Al Rendimiento Y Experiencia Visuals], James Loughman, Peter Davison, John M. Nolan, Mukunda C. Akkali, Stephen Beatty
Macular Pigment And Its Contribution To Visual Performance And Experience [El Pigmento Macular Y Su Contribución Al Rendimiento Y Experiencia Visuals], James Loughman, Peter Davison, John M. Nolan, Mukunda C. Akkali, Stephen Beatty
Articles
There is now a consensus, based on histological, biochemical and spectral absorption data, that the yellow colour observed at the macula lutea is a consequence of the selective accumulation of dietary xanthophylls in the central retina of the living eye. Scientific research continues to explore the function(s) of MP in the human retina, with two main hypotheses premised on its putative capacity to (1) protect the retina from (photo)-oxidative damage by means of its optical filtration and/or antioxidant properties, the so-called protective hypothesis and (2) influence the quality of visual performance by means of selective short wavelength light absorption prior …
An Evaluation Of A Community Dietetics Intervention On The Management Of Malnutrition For Healthcare Professionals, Sharon Kennelly, N. P. Kennedy, G. Flanaghan-Rughoobur, C. Glennon-Slattery, Sheila Sugrue
An Evaluation Of A Community Dietetics Intervention On The Management Of Malnutrition For Healthcare Professionals, Sharon Kennelly, N. P. Kennedy, G. Flanaghan-Rughoobur, C. Glennon-Slattery, Sheila Sugrue
Articles
Background: Healthcare professionals working in the community setting have limited knowledge of the evidence-based management of malnutrition. The present study aimed to evaluate a community dietetics intervention, which included an education programme for healthcare professionals in conjunction with the introduction of a community dietetics service for patients ‘at risk’ of malnutrition. Changes in nutritional knowledge and the reported management of malnourished patients were investigated and the acceptability of the intervention was explored. Methods: An education programme, incorporating ‘Malnutrition Universal Screening Tool (MUST)’ training, was implemented in eight of 10 eligible primary care practices (14 general practitioners and nine practice nurses …
Factors Associated With Weaning Practices In Term Infants: A Prospective Observational Study In Ireland., Roslyn Tarrant, Katherine Younger, Margaret Sheridan-Pereira, Martin White, John Kearney
Factors Associated With Weaning Practices In Term Infants: A Prospective Observational Study In Ireland., Roslyn Tarrant, Katherine Younger, Margaret Sheridan-Pereira, Martin White, John Kearney
Articles
The WHO (2001) recommends exclusive breast-feeding and delaying the introduction of solid foods to an infant’s diet until 6 months postpartum. However, in many countries, this recommendation is followed by few mothers, and earlier weaning onto solids is a commonly reported global practice. Therefore, this prospective, observational study aimed to assess compliance with the WHO recommendation and examine weaning practices, including the timing of weaning of infants, and to investigate the factors that predict weaning at #12 weeks. From an initial sample of 539 pregnant women recruited from the Coombe Women and Infants University Hospital, Dublin, 401 eligible mothers were …
The Prevalence And Determinants Of Breastfeeding Initiation And Duration In A Sample Of Women In Ireland, Roslyn Tarrant, Katherine Younger, Margaret Sheridan-Pereira, Martin White, John Kearney
The Prevalence And Determinants Of Breastfeeding Initiation And Duration In A Sample Of Women In Ireland, Roslyn Tarrant, Katherine Younger, Margaret Sheridan-Pereira, Martin White, John Kearney
Articles
Objective: To assess breast-feeding initiation and prevalence from birth to 6 months in a sample of mothers in Dublin, and to determine the factors associated with breast-feeding initiation and ‘any’ breast-feeding at 6 weeks in a sample of Irish-national mothers. Design: This prospective cross-sectional study involved the recruitment of women during the antenatal period, with subsequent follow-up of mothers who delivered healthy, term singleton infants, at 6 weeks and 6 months postpartum. Setting: Participants were recruited from antenatal clinics in the Coombe Women and Infants University Hospital, Dublin. Subjects: In all, 401 Irish-national and forty-nine non-Irish-national mothers met the criteria …
Platelet Alpha- And Beta- Secretase Activities Are Not Significantly Affected By Dementia Or Mild Cognitive Impairment In Swedish Patients., Paul Gorham, Natalie Bark, Steve Meaney, Ingemar Bjorkhem, Milita Crisby
Platelet Alpha- And Beta- Secretase Activities Are Not Significantly Affected By Dementia Or Mild Cognitive Impairment In Swedish Patients., Paul Gorham, Natalie Bark, Steve Meaney, Ingemar Bjorkhem, Milita Crisby
Articles
The processing of the Amyloid Precursor Protein (APP) is a critical event in the formation of amyloid plaques which are composed of the 4kDa amyloid beta-peptide (Abeta). Processing of APP occurs through a non-amyloidogenic pathway, mediated by initial alpha-secretase cleavage or through an amyloidogenic pathway via sequential cleavage by beta- and gamma-secretase enzymes, which produces Abeta peptides. Currently, the diagnosis of probable or possible Alzheimer's disease (AD) is primarily based on neuropsychological and neuroradiological assessment. Recent reports indicate that platelet beta-secretase activity is moderately increased in patients with AD and mild cognitive impairment (MCI). To our knowledge platelet alpha-secretase activity …
Genetic Connections Between Neurological Disorders And Cholesterol Metabolism, Ingemar Bjorkhem, Valerio Leoni, Steve Meaney
Genetic Connections Between Neurological Disorders And Cholesterol Metabolism, Ingemar Bjorkhem, Valerio Leoni, Steve Meaney
Articles
Cholesterol is an essential component of both the peripheral and central nervous systems of mammals. Over the last decade, evidence has accumulated that disturbances in cholesterol metabolism are associated with the development of various neurological conditions. In addition to genetically defined defects in cholesterol synthesis, which will be covered in another review in this Thematic Series, defects in cholesterol metabolism (cerebrotendinous xanthomatosis) and intracellular transport (Niemann Pick Syndrome) lead to neurological disease. A subform of hereditary spastic paresis (type SPG5) and Huntington's disease are neurological diseases with mutations in genes that are of importance for cholesterol metabolism. Neurodegeneration is generally …
Differential Genome-Wide Array–Based Methylation Profiles In Prognostic Subsets Of Chronic Lymphocytic Leukemia, Meena Kanduri, Nicola Cahill, Hanna Göransson, Camilla Enström, Fergus Ryan, Anders Isaksson, Richard Rosenquist
Differential Genome-Wide Array–Based Methylation Profiles In Prognostic Subsets Of Chronic Lymphocytic Leukemia, Meena Kanduri, Nicola Cahill, Hanna Göransson, Camilla Enström, Fergus Ryan, Anders Isaksson, Richard Rosenquist
Articles
Global hypomethylation and regional hypermethylation are well-known epigenetic features of cancer; however, in chronic lymphocytic leukemia (CLL), studies on genome-wide epigenetic modifications are limited. Here, we analyzed the global methylation profiles in CLL, by applying high-resolution methylation microarrays (27 578 CpG sites) to 23 CLL samples, belonging to the immunoglobulin heavy-chain variable (IGHV) mutated (favorable) and IGHV unmutated/IGHV3-21 (poor-prognostic) subsets. Overall, results demonstrated significant differences in methylation patterns between these subgroups. Specifically, in IGHV unmutated CLL, we identified methylation of 7 known or candidate tumor suppressor genes (eg, VHL, ABI3, and IGSF4) as well as 8 unmethylated genes involved in …
Sources Of Saturated Fat And Sucrose In The Diets Of Swedish Children And Adolescents In The European Youth Heart Study: Strategies For Improving Intakes, Emma Patterson, Julia Wärnberg, John Kearney, Michael Sjostrom
Sources Of Saturated Fat And Sucrose In The Diets Of Swedish Children And Adolescents In The European Youth Heart Study: Strategies For Improving Intakes, Emma Patterson, Julia Wärnberg, John Kearney, Michael Sjostrom
Articles
To compare macronutrient intakes of Swedish children and adolescents to population goals; to identify the major sources of energy, fat, saturated fat and sucrose; and to simulate the effect adherence to current food-based dietary guidelines (FBDG) would have on saturated fat and sucrose intakes. Cross-sectional study. From 24 h recall data, food groups contributing most to energy, fat, saturated fat and sucrose were identified. Based on the prevailing consumption of foods mentioned in the FBDG, we simulated five scenarios: changes in milk and yoghurt; cheese; energy-dense, nutrient-dilute foods; soft drinks; and burger and sausage consumption. Stockholm and Örebro (Sweden) in …
Exogenous Fms-Like Tyrosine Kinase 3 Ligand Overrides Brain Immune Privilege And Facilitates Recognition Of A Neo-Antigen Without Causing Autoimmune Neuropathology, Daniel Larocque, Nicholas S. R. Sanderson, Josée Bergeron, James Curtin, Joe Girton, Mia Wibowo, Niyati Bondale, Kurt M. Kroeger, Jieping Yang, Liliana M. Lacayo, Kevin C. Reyes, Catherine Farrokhi, Robert N. Pechnick, Maria G. Castro, Pedro R. Lowenstein
Exogenous Fms-Like Tyrosine Kinase 3 Ligand Overrides Brain Immune Privilege And Facilitates Recognition Of A Neo-Antigen Without Causing Autoimmune Neuropathology, Daniel Larocque, Nicholas S. R. Sanderson, Josée Bergeron, James Curtin, Joe Girton, Mia Wibowo, Niyati Bondale, Kurt M. Kroeger, Jieping Yang, Liliana M. Lacayo, Kevin C. Reyes, Catherine Farrokhi, Robert N. Pechnick, Maria G. Castro, Pedro R. Lowenstein
Articles
Soluble antigens diffuse out of the brain and can thus stimulate a systemic immune response, whereas particulate antigens (from infectious agents or tumor cells) remain within brain tissue, thus failing to stimulate a systemic immune response. Immune privilege describes how the immune system responds to particulate antigens localized selectively within the brain parenchyma. We believe this immune privilege is caused by the absence of antigen presenting dendritic cells from the brain. We tested the prediction that expression of fms-like tyrosine kinase ligand 3 (Flt3L) in the brain will recruit dendritic cells and induce a systemic immune response against exogenous influenza …
Multiple Asf/Sf2 Sites In The Human Papillomavirus Type 16 (Hpv-16) E4-Coding Region Promote Splicing To The Most Commonly Used 3'-Splice Site On The Hpv-16 Genome, Monika Somberg, Stefan Schwartz
Multiple Asf/Sf2 Sites In The Human Papillomavirus Type 16 (Hpv-16) E4-Coding Region Promote Splicing To The Most Commonly Used 3'-Splice Site On The Hpv-16 Genome, Monika Somberg, Stefan Schwartz
Articles
Our results presented here demonstrate that the most abundant human papillomavirus type 16 (HPV-16) mRNAs expressing the viral oncogenes E6 and E7 are regulated by cellular ASF/SF2, itself defined as a proto-oncogene and overexpressed in cervical cancer cells. We show that the most frequently used 3′-splice site on the HPV-16 genome, site SA3358, which is used to produce primarily E4, E6, and E7 mRNAs, is regulated by ASF/SF2. Splice site SA3358 is immediately followed by 15 potential binding sites for the splicing factor ASF/SF2. Recombinant ASF/SF2 binds to the cluster of ASF/SF2 sites. Mutational inactivation of all 15 sites abolished …
Editorial: Nutrition Research Reviews, Katherine Younger
Editorial: Nutrition Research Reviews, Katherine Younger
Articles
No abstract provided.
Hypercapnic Acidosis Reduces Oxidative Reactions In Endotoxin-Induced Lung Injury, Alistair D. Nichol, Donall F. O'Cronin, Finola Naughton, Natalie Hopkins, John Boylan, Paul Mcloughlin
Hypercapnic Acidosis Reduces Oxidative Reactions In Endotoxin-Induced Lung Injury, Alistair D. Nichol, Donall F. O'Cronin, Finola Naughton, Natalie Hopkins, John Boylan, Paul Mcloughlin
Articles
Hypercapnic acidosis frequently occurs when patients with acute lung injury are initially ventilated with low tidal volume "protective" strategies. Hypercapnic acidosis per se, in the absence of any change in tidal volume or airway pressure, is protective when instituted before the onset of injury. However, the mechanisms by which hypercapnic acidosis confers this protection are incompletely understood, in particular, the effects on pulmonary oxidative reactions, which are potent mediators of tissue damage, have not been previously examined in vivo.
An Optical Machine Vision System For Applications In Cytopathology, Jonathan Blackledge, Dmitry Dubovitskiy
An Optical Machine Vision System For Applications In Cytopathology, Jonathan Blackledge, Dmitry Dubovitskiy
Articles
This paper discusses a new approach to the processes of object detection, recognition and classification in a digital image focusing on problem in Cytopathology. A unique self learning procedure is presented in order to incorporate expert knowledge. The classification method is based on the application of a set of features which includes fractal parameters such as the Lacunarity and Fourier dimension. Thus, the approach includes the characterisation of an object in terms of its fractal properties and texture characteristics. The principal issues associated with object recognition are presented which include the basic model and segmentation algorithms. The self-learning procedure for …
Changes In Intraocular Pressure And Anterior Segment Morphometry After Uneventful Phacoemulsification Cataract Surgery, J. Dooley, S. Charalampidou, A. Malik, James Loughman, L. Molloy, S. Beatty
Changes In Intraocular Pressure And Anterior Segment Morphometry After Uneventful Phacoemulsification Cataract Surgery, J. Dooley, S. Charalampidou, A. Malik, James Loughman, L. Molloy, S. Beatty
Articles
Purpose To study changes in anterior segment morphometry after uneventful phacoemulsification cataract surgery, and to investigate whether there is a relationship between any observed changes and intraocular pressure (IOP) reduction after the procedure. Methods The anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), central corneal thickness (CCT), and IOP were measured in 101 non-glaucomatous eyes before and after uneventful phacoemulsification cataract surgery. Results After cataract surgery, the mean ACD, ACV, and ACA values increased by 1.08mm, 54.4mm3, and 13.11, respectively, and the mean IOP (corrected for CCT) decreased by 3.2mmHg. The predictive value of a previously …
Solar Simulated Radiation Induced Cell Death Depends On Spectral Distribution And Irradiance But Not Output Delivery, Alanna Maguire, Fiona Lyng, James Walsh
Solar Simulated Radiation Induced Cell Death Depends On Spectral Distribution And Irradiance But Not Output Delivery, Alanna Maguire, Fiona Lyng, James Walsh
Articles
Photo biological investigations are dependent on calibration and characterisation to determine the relevance of an artificial irradiator to the study at hand. The importance of this has been voiced in the literature. However, the importance of output delivery is relatively unknown. The biological relevance of a high energy, rapidly pulsing solar simulator was investigated using the clonogenic assay and was found to be reciprocity law compliant despite an exaggerated UV irradiance in excess of 1600 Wm-2 delivered per pulse. In fact, it was found to be the least cytotoxic irradiator compared to a second solar simulator and a UVB fluorescent …
High-Density Screening Reveals A Different Spectrum Of Genomic Aberrations In Chronic Lymphocytic Leukemia Patients With ‘Stereotyped’ Ighv3-21 And Ighv4-34 B-Cell Receptors, Millaray Marincevic, Nicola Cahill, Rebeqa Gunnarsson, Anders Isaksson, Mahmoud Mansouri, Hanna Göransson, Markus Rasmussen, Mattias Jansson, Fergus Ryan, Karin Karlsson, Hans-Olov Adami, Fred Davi, Jesper Jurlander, Gunnar Juliusson, Kostas Stamatopoulos, Richard Rosenquist
High-Density Screening Reveals A Different Spectrum Of Genomic Aberrations In Chronic Lymphocytic Leukemia Patients With ‘Stereotyped’ Ighv3-21 And Ighv4-34 B-Cell Receptors, Millaray Marincevic, Nicola Cahill, Rebeqa Gunnarsson, Anders Isaksson, Mahmoud Mansouri, Hanna Göransson, Markus Rasmussen, Mattias Jansson, Fergus Ryan, Karin Karlsson, Hans-Olov Adami, Fred Davi, Jesper Jurlander, Gunnar Juliusson, Kostas Stamatopoulos, Richard Rosenquist
Articles
Background The existence of multiple subsets of chronic lymphocytic leukemia expressing ‘stereotyped’ Bcell receptors implies the involvement of antigen(s) in leukemogenesis. Studies also indicate that ‘stereotypy’ may influence the clinical course of patients with chronic lymphocytic leukemia, for example, in subsets with stereotyped IGHV3-21 and IGHV4-34 B-cell receptors; however, little is known regarding the genomic profile of patients in these subsets. Design and Methods We applied 250K single nucleotide polymorphism-arrays to study copy-number aberrations and copy-number neutral loss-of-heterozygosity in patients with stereotyped IGHV3-21 (subset #2, n=29), stereotyped IGHV4-34 (subset #4, n=17; subset #16, n=8) and non-subset #2 IGHV3-21 (n=13) and …
Dietary Energy Density As Marker Of Dietary Quality In Swedish Children And Adolescents: The European Youth Heart Study, Emma Patterson, J. Wärnberg, E. Poortvliet, John Kearney, M. Sjöström
Dietary Energy Density As Marker Of Dietary Quality In Swedish Children And Adolescents: The European Youth Heart Study, Emma Patterson, J. Wärnberg, E. Poortvliet, John Kearney, M. Sjöström
Articles
To investigate if dietary energy density is associated with measures of dietary quality (food group, micronutrient and macronutrient intakes) in children and adolescents.
Macular Pigment And Its Contribution To Visual Performance And Experience, James Loughman, Peter Davison, John Nolan, Mukunda Akkali, Stephen Beatty
Macular Pigment And Its Contribution To Visual Performance And Experience, James Loughman, Peter Davison, John Nolan, Mukunda Akkali, Stephen Beatty
Articles
There is now a consensus, based on histological, biochemical and spectral absorption data, that the yellow colour observed at the macula lutea is a consequence of the selective accumulation of dietary xanthophylls in the central retina of the living eye. Scientifi c research continues to explore the function(s) of MP in the human retina, with two main hypotheses premised on its putative capacity to (1) protect the retina from (photo)-oxidative damage by means of its optical fi ltration and/or antioxidant properties, the so-called protective hypothesis and (2) infl uence the quality of visual performance by means of selective short wavelength …