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Inclusion Body Myositis: Report Of A Case, Chein-Wei Chang, Tien-Jye Chang, Ming-Shiang Wu, Che-Yen Chen

Rehabilitation Practice and Science

A female of age 30 years developed a muscular weakness in proximal extremities during 2 years and responded poorly to steroid treatment. Creatine kinase in isoenzymic MM form was markedly elevated according to a serum muscle enzyme test. Electromyography examination showed a myopathic feature. Histopathological tests in muscle biopsy specimens revealed prominent cytoplasmic vacuoles rimmed by basophilic granules under space optical microscopy, and abundant intranuclear filamentous inclusions in electron microscopy. These clinical features and athological especially electron microscopic findings are considered to be of paramount importance for the diagnosis of inclusion body myositis.