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Full-Text Articles in Medicine and Health Sciences
Outcome Of Solid And Cavitary Pulmonary Nodules In Rheumatoid Arthritis Patients? Case Series, Aysun Aksoy, Derya Kocakaya, Yasemi̇n Yalçinkaya, Emi̇ne Bozkurtlar, Sai̇t Karakurt, Semi̇ha Emel Eryüksel, Güzi̇de Nevsun İnanç
Outcome Of Solid And Cavitary Pulmonary Nodules In Rheumatoid Arthritis Patients? Case Series, Aysun Aksoy, Derya Kocakaya, Yasemi̇n Yalçinkaya, Emi̇ne Bozkurtlar, Sai̇t Karakurt, Semi̇ha Emel Eryüksel, Güzi̇de Nevsun İnanç
Turkish Journal of Medical Sciences
Background/aim: Rheumatoid pulmonary nodule can be detected in up to 32% of rheumatoid arthritis (RA) patients and approximately one-third of nodules may cavitate. We aimed to evaluate characteristics of patients with RA developing cavitary pulmonary nodular (CPN) lesions under disease-modifying antirheumatic drugs (DMARDs), follow-up of both cavitary and solid nodules, and their outcome with the treatment. Materials and methods: RA patients who presented with CPN lesions during follow-up were recruited retrospectively in this case series analysis. Total numbers and mean diameters of cavitary and solid nodules in each thorax computed tomography (CT) have been determined and followed up by two …
Egfr Blocker Lapatinib Inhibits The Synthesis Of Matrix Metalloproteinases From Synovial Fibroblasts, Demet Yalçin Kehri̇bar, Hakan Emmungi̇l, Neşe Başak Türkmen, Osman Çi̇ftçi̇, Emi̇ne Şalva, Meti̇n Özgen
Egfr Blocker Lapatinib Inhibits The Synthesis Of Matrix Metalloproteinases From Synovial Fibroblasts, Demet Yalçin Kehri̇bar, Hakan Emmungi̇l, Neşe Başak Türkmen, Osman Çi̇ftçi̇, Emi̇ne Şalva, Meti̇n Özgen
Turkish Journal of Medical Sciences
Background/aim: Epidermal growth factor receptor (EGFR) family members and their associated ligands may be related to bone and joint destruction in rheumatoid arthritis. Matrix metalloproteinases are responsible for joint and bone tissue degradation. This study is intended to investigate the effect of epidermal growth factor receptor inhibition by lapatinib on the synthesis of matrix metalloproteinases in in vitro. Materials and methods: Synovial fibroblast cell culture was obtained from a patient with rheumatoid arthritis who underwent knee arthroplasty. Interleukin-1ß (IL-1ß) and tumor necrosis factor-∝ (TNF-∝) were added to the cell culture to stimulate synovial fibroblast cells and create an inflammatory character. …