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Functional Vitamin B12 Deficiency Represented By Elevated Urine Methylmalonic Acid Levels In Patients With Migraine, Osman Meti̇n İpçi̇oğlu, Ömer Özcan, Mustafa Gültepe, Hakan Tekeli̇, Mehmet Güney Şenol
Functional Vitamin B12 Deficiency Represented By Elevated Urine Methylmalonic Acid Levels In Patients With Migraine, Osman Meti̇n İpçi̇oğlu, Ömer Özcan, Mustafa Gültepe, Hakan Tekeli̇, Mehmet Güney Şenol
Turkish Journal of Medical Sciences
Aims: Although vitamin B12 is currently used as a treatment option in patients with migraine, a possible cobalamin deficiency in those patients has not yet been investigated. In this study, we aimed to investigate cobalamin metabolism in patients with migraine. Materials and Methods: Fifty women having migraine without aura were matched with healthy controls (n=6) with the same age distribution. Fasting serum vitamin B12, folate, plasma total homocysteine (tHcy) and first morning urine methylmalonic acid (MMA) levels were determined in patient and control groups. Statistical differences in laboratory parameters between patient and control groups were analyzed by SPSS for Windows …
Serum Homocysteine Levels In Highway Toll Collectors And The Relationship With Intima-Media Thickness Of The Carotid Artery, Ramazan Memi̇şoğullari, Beşi̇r Erdoğmuş, Hami̇t Hakan Alp, Cahi̇t Bi̇lgi̇n, Peri̇ Meram Arbak, Özlem Yavuz
Serum Homocysteine Levels In Highway Toll Collectors And The Relationship With Intima-Media Thickness Of The Carotid Artery, Ramazan Memi̇şoğullari, Beşi̇r Erdoğmuş, Hami̇t Hakan Alp, Cahi̇t Bi̇lgi̇n, Peri̇ Meram Arbak, Özlem Yavuz
Turkish Journal of Medical Sciences
Aim: A relationship between air pollution and increased intima-media thickness (IMT) has been recently reported, but its etiology is not yet well understood. We aimed to determine whether exposure to exhaust particles, which are important air pollutants, is associated with increased serum homocysteine (Hcy) levels and whether elevated Hcy levels are associated with increased IMT. Materials and Methods: Serum Hcy levels were measured by fluorometric high performance liquid chromatography in 65 male highway toll collectors (HTCs) and 43 healthy male volunteers. IMT was measured with Doppler sonography by an experienced radiologist. Results: Serum Hcy levels (14.5 ± 4.9 mmol/L, P < 0.005) and IMT (0.757 ± 0.18 mm, P < 0.001) were higher in the HTC group than in controls (12.0 ± 2.8 mmol/L and 0.612 ± 0.11 mm, respectively). A positive correlation was found between Hcy level and IMT both in the HTC group (r = 0.36; P < 0.005) and in the control group (r = 0.36; P < 0.05). Conclusions: Exposure to exhaust particles may cause an increase in oxidative stress because of an increase in serum Hcy levels, which consequently may lead to an increase in IMT. Nevertheless, further studies on the subject are needed before drawing a firm conclusion.