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Attenuation Of Vasospasm By Dexmedetomidine After Experimental Subarachnoidal Haemorrhage In Rabbits, Olcay Eser, Hüseyi̇n Fi̇dan, Ömer Çoşkun, Yüksel Ela, Ahmet Songur, Murat Coşar
Attenuation Of Vasospasm By Dexmedetomidine After Experimental Subarachnoidal Haemorrhage In Rabbits, Olcay Eser, Hüseyi̇n Fi̇dan, Ömer Çoşkun, Yüksel Ela, Ahmet Songur, Murat Coşar
Turkish Journal of Medical Sciences
Aim: Vasospasm is one of the most important factors that influence the successful treatment of ruptured intracranial aneurysm. We studied if vasospasm following subarachnoidal haemorrhage (SAH) can be alleviated by dexmedetomidine in an animal model. Materials and Methods: Experimental SAH was induced in 12 of 18 New Zealand rabbits by intracisternal injection of autologous blood. Control animals (sham SAH, n = 6) received intracisternal injection of the respective volume of physiological saline solution. Forty eight hours after the operation, rabbits in sham SAH and SAH-alone (n = 6) groups were infused intravenously with 0.9% sodium chloride for 2 h, whereas …
The Effects Of Perioperative Low - Moderate Doses Of Dexmedetomidine Infusion On Hemodynamic And Neuroendocrine Parameters, Çeti̇n Kaymak, Hülya Başar, Nur Doğanci, Özgür Sert, Alpaslan Apan
The Effects Of Perioperative Low - Moderate Doses Of Dexmedetomidine Infusion On Hemodynamic And Neuroendocrine Parameters, Çeti̇n Kaymak, Hülya Başar, Nur Doğanci, Özgür Sert, Alpaslan Apan
Turkish Journal of Medical Sciences
Aim: The aim of this study was to determine the effects of low and moderate doses of dexmedetomidine infusions by evaluating hemodynamic and neuroendocrine responses in patients undergoing elective transurethral surgery. Materials and Methods: Fifty patients were randomly allocated to receive 0.45 (Group 1) or 0.6 (Group 2) µg kg^{-1} hr^{-1} dexmedetomidine infusion 10 minutes before induction of anesthesia. Heart rate, blood pressures, ETCO2 and peripheral oxygen saturation values and parameters of non-invasive cardiac output were monitored. Measurement times were baseline (I), after dexmedetomidine infusion (II), after thiopental induction (III), after intubation (IV) and at 10-minute intervals during desflurane anesthesia. …