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Rapid And Simultaneous Determination Of Acetylsalicylic Acid, Paracetamol, And Their Degradation And Toxic Impurity Products By Hplc In Pharmaceutical Dosage Forms, Cemal Akay, İsmai̇l Tuncer Deği̇m, Ahmet Sayal, Ahmet Aydin, Yalçin Özkan, Hüsametti̇n Gül
Rapid And Simultaneous Determination Of Acetylsalicylic Acid, Paracetamol, And Their Degradation And Toxic Impurity Products By Hplc In Pharmaceutical Dosage Forms, Cemal Akay, İsmai̇l Tuncer Deği̇m, Ahmet Sayal, Ahmet Aydin, Yalçin Özkan, Hüsametti̇n Gül
Turkish Journal of Medical Sciences
Aims: Determinations of drug impurity and drug degradation products are very important from both pharmacological and toxicological perspectives. Establishment of monitoring methods for impurities and degradation products during pharmaceutical development is necessary because of their potential toxicity. The aim of this study was to develop a rapid and simultaneous determination method for paracetamol and acetylsalicylic acid (ACA) and their degradation and toxic impurity products by high performance liquid chromatography (HPLC) in pharmaceutical dosage forms. Materials and Methods: A reverse phase (RP)-HPLC method for the simultaneous analysis of paracetamol, ACA, and ascorbic acid and their degradation and impurity products such as …