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Antitumor Effects Of Tnf-\Beta, 5-Fu And Their Combinations On Cervical Carcinoma Cell Lines, Hakan Akça, Osman Ni̇dai̇ Özeş
Antitumor Effects Of Tnf-\Beta, 5-Fu And Their Combinations On Cervical Carcinoma Cell Lines, Hakan Akça, Osman Ni̇dai̇ Özeş
Turkish Journal of Medical Sciences
Cervical carcinoma is one type of cancer with a high mortality rate in females. In this study, we investigated the cytotoxic effects of TNF-\beta, 5-FU and their combinations on human cervical carcinoma cell lines, ME180 and HeLa. The highest degree of cytotoxic effect was obtained with 5-FU on both cell lines. While high concentrations of TNF-\beta showed cytotoxic effects on both cell lines, the lowest dose induced growth. Combination treatment of 5-FU and TNF-\beta gave a slightly higher cytotoxic and antiproliferative response compared to individual use of 5-FU and TNF-\beta on both cell lines.