Medicine and Health Sciences Commons^™

Calcitriol And Calcipotriol Modulate Transport Activity Of Abc Transporters And Exhibit Selective Cytotoxicity In Mrp1-Overexpressing Cells, Kee W. Tan, Angelina Sampson, Bremansu Osa-Andrews, Surtaj H. Iram

Chemistry and Biochemistry Faculty Publications

Efflux transporters P-glycoprotein (P-gp/ABCB1), multidrug resistance protein 1 (MRP1/ABCC1), and breast cancer resistance protein (BCRP/ABCG2) can affect the efficacy and toxicity of a wide variety of drugs and are implicated in multidrug resistance (MDR). Eight test compounds, recently identified from an intramolecular FRET-based high throughput screening, were characterized for their interaction with MRP1. We report that the active metabolite of vitamin D3, calcitriol, and its analog calcipotriol are selectively cytotoxic to MRP1-overexpressing cells, besides inhibiting transport function of P-gp, MRP1, and BCRP. Calcitriol and calcipotriol consistently displayed a potent inhibitory activity on MRP1-mediated doxorubicin and calcein efflux in MRP1-overexpressing H69AR …

Development And Validation Of A Simple Convenience Store Shelf Audit., Tanya M. Horacek, Elif Dede Yildirim, Erin Kelly, Adrienne A. White, Karla P. Shelnutt, Kristin Riggsbee, Melissa D. Olfert, Jesse Morrell, Anne E. Matthews, Terezie T Mosby, Tandalayo Kidd, Kendra Kattelmann, Geoffrey Greene, Lisa Franzen-Castle, Sarah E. Colby, Carol Byrd-Bredbenner, Onikia Brown

Health and Nutritional Sciences Faculty Publications

ackground This paper describes the development, reliability, and convergent validity of a practical tool-the Convenience StoreSupportive Healthy Environment for Life-Promoting Food (SHELF) Audit. Methods Audit items included: a variety of fresh, processed, and frozen fruits and vegetables; low-fat dairy products; healthy staples and frozen meals; healthy food incentive programs; items sold in check-out areas; portion/cup sizes; and pricing. Each audit item was scored using a five-point semantic-differential scale (1 = provides little or no support for healthful foods to 5 = provides high support for healthful foods). Convergent validity was examined by comparing the SHELF audit to Ghirardelli et al. …

Native Elder And Youth Perspectives On Mental Well-Being, The Value Of The Horse, And Navigating Two Worlds, Mary J. Isaacson, Rebecca Bott-Knutson, Mary Beth Fishbeck, Angela Varnum, Shelly Brandenburger

College of Nursing Faculty Publications

Purpose: Native American youth experience significant challenges to mental well-being. As part of a larger study to evaluate hope and resilience in a Plains tribal population, the purpose of this study was to learn from Native American elders and youths what they feel is needed to for youth to grow up healthy on the reservation, and to identify connections between horse use and mental well-being.
Sample: Six Native American elders and eight Native American youths from the same Plains tribe.
Method: The research team conducted Talking Circles with youths and elders. during the Talking Circles, participants identified community-specific questions for …

Querying Rural Content Experts Using An Online Questionnaire, Marilyn A. Swan, Barbara B. Hobbs

College of Nursing Faculty Publications

Purpose: Obtaining feedback from rural content experts is critical in developing valid and reliable instruments to advance the science of rural health. However, traditional methods, i.e., focus groups are impractical due to location and distance. Using an online questionnaire combined with telephone and email contacts to obtain content experts’ feedback is discussed. Item statement analysis and efficiency and effectiveness of the process are presented.
Methods: The process included the development of an online questionnaire, asking experts to rate 51 item statement for their relevancy, sufficiency of description, and clarity and readability. To increase the response rate, a series of four …

Health Behaviors Of Student Community Research Partners When Designing And Implementing A Healthy Lifestyle Intervention On College Campuses., Makenzie L. Barr, Sarah E. Colby, Kristin Riggsbee, Krista Leischner, Anne E. Matthews, Melissa J Vilaro, Kendra Kattelmann, Melissa D. Olfert

Health and Nutritional Sciences Faculty Publications

Few studies work with college students as equal partners in all aspects of Community-Based Participatory Research (CBPR) and even less evaluate behaviors of those college partners. The current study aimed to examine health behaviors of students by designing and implementing a peer-led, social marketing campaign (Get Fruved) to promote healthier lifestyles on their campuses. Enrolled students (n = 376) were trained to either design and implement a health promotion intervention (Social Marketing and Environmental Interventionists; SMEI, n = 78), be peer mentors (PM; n = 205), or serve as control participants (n = 93). Students' behaviors (dietary, activity, and stress) …

Multilevel Structural Equation Modeling Of Students' Dietary Intentions/Behaviors, Bmi, And The Healthfulness Of Convenience Stores., Tanya M. Horacek, Elif Dede Yildirim, Kendra Kattelmann, Carol Byrd-Bredbenner, Onikia Brown, Sarah E. Colby, Geoffrey Greene, Sharon Hoerr, Tandalayo Kidd, Mallory Koenings, Jesse Morrell, Melissa D. Olfert, Beatrice Phillips, Karla P. Shelnutt, Adrienne A. White

Health and Nutritional Sciences Faculty Publications

BACKGROUND: When dietary behaviors are habitual, intentions are low, and environmental cues, such as the consumer food environment, might guide behavior. How might intentions to eat healthily and ultimately actual dietary behaviors, be influenced by the consumer food environment (including the availability and affordability of healthy foods) in convenience stores? This study will determine pathways between the healthfulness of convenience stores and college students' dietary intentions/behaviors, and body mass index (BMI).
METHODS: Through multilevel structural equation modeling, a comparison was made of students' healthful meal intentions (HMI); intake (fruits/vegetables, %kcal/fat, sugar-sweetened beverages (SSBs) and whole-grains); and measured BMI; as well …

Development Of Novel Intramolecular Fret-Based Abc Transporter Biosensors To Identify New Substrates And Modulators, Bremansu Osa-Andrews, Kee W. Tan, Angelina Sampson, Surtaj H. Iram

Chemistry and Biochemistry Faculty Publications

Multidrug resistance protein 1 (MRP1) can efflux a wide variety of molecules including toxic chemicals, drugs, and their derivatives out of cells. Substrates of MRP1 include anti-cancer agents, antibiotics, anti-virals, anti-human immunodeficiency virus (HIV), and many other drugs. To identify novel substrates and modulators of MRP1 by exploiting intramolecular fluorescence resonance energy transfer (FRET), we genetically engineered six different two-color MRP1 proteins by changing green fluorescent protein (GFP) insertion sites, while keeping the red fluorescent protein (RFP) at the C-terminal of MRP1. Four of six recombinant proteins showed normal expression, localization, and transport activity. We quantified intramolecular FRET using ensemble …

A Community Based Participatory Approach To Training Young Adults To Design And Implement A Social Marketing Framed Lifestyle Intervention On Their College Campus, Melissa D. Olfert, Makenzie L. Barr, Kristin Riggsbee, Kendra K. Kattelmann, Krista Leischner, Anne E. Mathews, Melissa Vilaro, Sarah E. Colby

Health and Nutritional Sciences Faculty Publications

Background: Using a Community-Based Participatory Research (CBPR) approach may increase the likelihood of relevance and acceptability of the designed intervention, especially on a college campus. Furthermore, recruiting and training college students to design a social marketing framed healthy lifestyle intervention for their peers will allow the intervention to be tailored to the needs of the campus. Objectives: To describe the process of online-course training college students to develop a campus-based, social marketing health promotion intervention. Methods: Four universities recruited current college students (18+ y.o.) to develop a social marketing and environmental intervention (SMEI), which was completed during a 16-week, online/in-person …

Improving The Nutrition And Screen Time Environment Through Self-Assessment In Family Childcare Homes In Nebraska, Dipti A. Dev, Natalie Williams, Iheoma Iruka, Aileen Garcia, Yage Guo, Irina Patwardhan, Katrina Cummings, Zainab Rida, Emily Hulse, Ami Sedani

Counseling and Human Development Faculty Publications

Objective: To determine if family childcare homes (FCCH) in Nebraska meet best practices for nutrition and screen time, and if focusing on nutrition and screen time policies and practices improves the FCCH environment. Design: A pre–post evaluation was conducted using the Go Nutrition and Physical Activity Self-Assessment for Childcare (Go NAP SACC). Setting: FCCH in Nebraska, USA. Subjects: FCCH enrolled in the Child and Adult Care Food Program (CACFP; n 208) participated in a pre–post evaluation using Go NAP SACC. Results: At baseline, all FCCH met the minimum childcare standards for fifty-four of fifty-six practices in nutrition and screen time. …

Voices For Food: Methodologies For Implementing A Multi-State Community-Based Intervention In Rural, High Poverty Communities., Suzanne Stluka, Lindsay Moore, Heather A Eicher-Miller, Lisa Franzen-Castle, Becky Henne, Donna Mehrle, Daniel Remley, Lacey Mccormack

Health and Nutritional Sciences Faculty Publications

BACKGROUND: Rural communities experience unique barriers to food access when compared to urban areas and food security is a public health issue in rural, high poverty communities. A multi-leveled socio-ecological intervention to develop food policy councils (FPCs), and improve food security in rural communities was created. Methods to carry out such an intervention were developed and are described.
METHODS: A longitudinal, matched treatment and comparison study was conducted in 24 rural, high poverty counties in South Dakota, Indiana, Missouri, Michigan, Nebraska and Ohio. Counties were assigned to a treatment (n = 12) or comparison (n = 12) group. Intervention activities …

Early Hearing Detection Intervention (Ehdi) Program: What Is The Data Telling Us?, Bonny Specker, Lucy Fossen

Ethel Austin Martin Program Publications

Hearing impairments in infants can negatively impact speech and language development, academic achievement, and social and emotional development if left undetected. These negative impacts can be reduced through early intervention. There are three goals of the EHDI Program:

• All newborns will be screened for hearing loss before 1 month of age, preferably before hospital discharge.
• All infants who screen positive will have a diagnostic audiologic evaluation before three months of age.
• All infants diagnosed with a hearing loss will receive appropriate early intervention services before 6 months of age.

The South Dakota Department of Health recently evaluated 2010-2015 EHDI data …

South Dakota Pregnancy Risk Assessment Monitoring System (Prams), Maggie Minett, Tianna Beare, Bonny Specker

Ethel Austin Martin Program Publications

The Pregnancy Risk Assessment Monitoring System (PRAMS) was developed by the Centers for Disease Control and Prevention (CDC) in 1987 and is done in collaboration with various state health departments. PRAMS is a statewide survey that collects valuable information from new mothers on behaviors and attitudes before, during and after pregnancy to find out why some babies are born healthy and others are not. Currently, 47 states, New York City, Puerto Rico, the District of Columbia and the Great Plains Tribal Chairmen’s Health Board (GPTCHB) participate in the PRAMS survey, representing approximately 83% of all U.S. live births. The Ethel …

Comfort With Communication In Palliative And End Of Life Care (C-Cope), Mary J. Isaacson, Mary E. Minton

College of Nursing Faculty Publications

The C-COPE instrument is based on literature review, content from the COMFORT model, and iterative input from four content experts. The COMFORT communication model is grounded in patient-centered care and narrative medicine, where patients, families, and the healthcare team value each other’s story and collaboratively identify wishes and goals of care. COMFORT communication skills include bearing witness, understanding health literacy, actively listening, understanding family communication patterns, talking through the tension, embracing patient and family goals of care, and learning to collaborate with members of the team. The C-COPE operationalizes the key components of the COMFORT model: Communication, Orientation and opportunity, …

Daily Dietary Intake Patterns Improve After Visiting A Food Pantry Among Food-Insecure Rural Midwestern Adults., Breanne N Wright, Regan L Bailey, Bruce A Craig, Richard D Mattes, Lacey Mccormack, Suzanne Stluka, Lisa Franzen-Castle, Becky Henne, Donna Mehrle, Dan Remley, Heather A Eicher-Miller

Health and Nutritional Sciences Faculty Publications

Emergency food pantries provide food at no cost to low-resource populations. The purpose of this study was to evaluate single-day dietary intake patterns before and after visiting a food pantry among food-secure and food-insecure pantry clients. This observational cohort study comprised a paired, before-and-after design with a pantry visit as the intervention. Participants (n = 455) completed a demographic and food security assessment, and two 24-h dietary recalls. Adult food security was measured using the U.S. Household Food Security Survey Module. Dietary intake patterns were assessed using Automated Self-Administered 24-h Recall data and classified by Healthy Eating Index (HEI-2010) …

Quality Of Life Associated With Physical Activity But Not Sedentary Time In Youth, K. Kattelmann, E. Hofer, C. Merfeld, J. Meendering, M. Olfert, J. White, S. Colby, R. Meade, L. Franzen-Castle, T. Aquirre, D. Matthews, A. White

Health and Nutritional Sciences Faculty Publications

Purpose: It has been reported that youth who engaged in more screen time had lower quality of life scores compared to those that were more physically active. Furthermore, increased sedentary behavior increases health risks particularly the risk for obesity. A cross-sectional analysis was completed to examine the relationship between healthrelated quality-of-life (HRQOL) and accelerometer-measured sedentary time (ST) and physical activity (PA) in 9-10-yearold youth who were recruited for the family-based, childhood obesity intervention, iCook 4-H. It was hypothesized that objectively measured ST would be negatively correlated and PA would be positively correlated with HRQOL.
Methods: A subset of participants (n=118) …

Prevalence And Predictors Of Household Food Insecurity Among Adult/Youth Dyads At The Initiation Of The Icook 4-H Two-Year Obesity Prevention Study, M. Mcelrone, S. E. Colby, L. Franzen-Castle, M. D. Olfert, K. Kattelmann, Adrienne A. White

Health and Nutritional Sciences Faculty Publications

Objective: Determine food insecurity prevalence and predictors among adult/youth dyads enrolled in a childhood obesity prevention study (iCook 4-H).
Methods: The iCook 4-H intervention was designed for youth (9-10 years old) and their adult main meals preparer to cook, eat, and play together. Although not an inclusion criteria, diverse, low income, and/or rural families were the target during recruitment. At baseline, adults completed surveys on food insecurity, socioeconomic and demographic characteristics and youth anthropometrics were collected with body mass index (BMI) calculated. Descriptive statistics were computed and chi-square analysis was conducted to test differences between potential predictors and food insecurity. …

Provision Of Survivorship Care Plans In Hard To Reach Patient Populations, Jenna Cowan, Jennifer Kerkvliet

College of Nursing Faculty Publications

Table of Contents
Acknowledgments [page] 1
The Case for Survivorship Care Plans [page] 3
Accreditation Standards for Survivorship Programs [page] 4
Hard to Reach Patient Populations [page] 5
Methods [page] 6
Models of Collaboration to Reach Survivors of Urological Cancers [page] 8
Model #1 [page] 9
Model #2 [page] 13
Summary of Collaborations [page] 16
References [page] 18

The Effect Of Icook 4-H, A Childhood Obesity Prevention Program, On Blood Pressure And Quality Of Life In Youth And Adults: A Randomized Control Trial, M. D. Olfert, O. A. Famodu, S. Flanagan, E. Smith, M. P. Leary, R. L. Hagedorn, J. A. White, M. M. Koenings, S. E. Colby, K. Kattelmann, L. Franzen-Castle, Adrienne A. White

Health and Nutritional Sciences Faculty Publications

Objective: Obesity increases the risk of developing hypertension and from population-based samples with estimations that of 2-4% of the U.S. pediatric population has hypertension, which may affect quality of life. This study examined the effects of an obesity prevention program on blood pressure and quality of life in youth and adult participants.
Methods: A multi-state research team recruited treatment dyads (youth and their adult meal preparer) to participate in a 12-week randomized control trial and follow-up through 24 months. The treatment group received a cooking and physical activity intervention, followed by booster sessions and mailed newsletters over the remaining two-year …

Qualitative Analysis Of Grocery Store And Farmers Market Manager Perceptions Regarding Use Of Fruit And Vegetable Educational Materials, Lacey Mccormack, Shelly Brandenburger, Karlys Wells, Suzanne Stluka

Health and Nutritional Sciences Faculty Publications

The Pick it! Try it! Like it! (PTL) educational resource set, developed to display in grocery stores and farmers markets, teaches individuals how to shop for and prepare healthy fruit and vegetable dishes. Because program buy-in must be obtained from location managers before implementation occurs, the purpose of this study was to qualitatively examine the perceptions that grocery store and farmers market managers have regarding PTL implementation. Locations that requested PTL materials during 2013-14 were contacted and asked to answer 13 questions. Responses were analyzed using the content analysis method with themes generated and frequencies reported. Analyses examined manager perceptions …

Bridging University Institutional And Accreditation Standards: An Advanced Practice Registered Nurse (Aprn) Program Exemplar, R. Arends, V. Britson, M. E. Minton

College of Nursing Faculty Publications

The complexity of the health care environment requires the nursing profession to effectively anticipate current and future health care needs. Similarly, nursing education must ensure preparedness of future nursing professionals as well as meet the rigor of program accreditation standards. South Dakota State University (SDSU) College of Nursing Master’s and Doctor of Nursing Practice (DNP) programs are accredited by the Commission on Collegiate Nursing Education (CCNE), one of the two national specialized accrediting bodies for nursing. Both graduate programs must align with an American Association of Colleges of Nursing (AACN) Essentials document that corresponds to the respective degree and specialty, …