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Full-Text Articles in Medicine and Health Sciences
Characterization Of Bovine-Derived Porous Hydroxyapatite Scaffold And Its Potential To Support Osteogenic Differentiation Of Human Bone Marrow Derived Mesenchymal Stem Cells., Krishnamurithy G, Murali Mr, Hamdi M, Abbas Aa, Raghavendran Hb, Kamarul T
Characterization Of Bovine-Derived Porous Hydroxyapatite Scaffold And Its Potential To Support Osteogenic Differentiation Of Human Bone Marrow Derived Mesenchymal Stem Cells., Krishnamurithy G, Murali Mr, Hamdi M, Abbas Aa, Raghavendran Hb, Kamarul T
Murali Malliga Raman
Porous three-dimensional hydroxyapatite (HA) scaffolds were prepared using bovine cortical bone derived HA (BDHA). Analyses of the morphology, chemical composition, and phase purity of the scaffold were performed using scanning electron microscopy (SEM), micro-computer tomography (micro-CT), Fourier transform infrared spectroscopy (FTIR), energy dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD). SEM images revealed the rough and porous surface of the scaffold, while micro-CT showed the average porous volume of 76.7±0.6% and pore size of 0.04–0.25 mm. Single phase corresponding to standard HA was observed using XRD, and FTIR confirmed the presence of functional groups similar to HA. The EDX analysis …
Histology, Glycosaminoglycan Level And Cartilage Stiffness In Monoiodoacetate-Induced Osteoarthritis: Comparative Analysis With Anterior Cruciate Ligament Transection In Rat Model And Human Osteoarthritis, Naveen Sv, Ahmad Re, Hui Wj, Suhaeb Am, Murali Malliga Raman, Shanmugam R, Kamarul T
Histology, Glycosaminoglycan Level And Cartilage Stiffness In Monoiodoacetate-Induced Osteoarthritis: Comparative Analysis With Anterior Cruciate Ligament Transection In Rat Model And Human Osteoarthritis, Naveen Sv, Ahmad Re, Hui Wj, Suhaeb Am, Murali Malliga Raman, Shanmugam R, Kamarul T
Murali Malliga Raman
Monosodium -iodoacetate (MIA)-induced animal model of osteoarthritis (OA) is under-utilised despite having many inherent advantages. At present, there is lack of studies that directly compare the degenerative changes induced by MIA with the surgical osteoarthritis induction method and human osteoarthritis, which would further verify a greater use of this model. Therefore, we compared the histological, biochemical and biomechanical characteristics in rat model using MIA against the anterior cruciate ligament transection (ACLT) and human cartilage with clinically established osteoarthritis. The right knees of Sprague-Dawley rats were subjected to either MIA or ACLT (n=18 in each group). Six rats were used as …
Fluoroscopy Assisted Minimally Invasive Transplantation Of Allogenic Mesenchymal Stromal Cells Embedded In Hystemtm Reduce The Progression Nucleus Pulposus Degeneration In The Damaged Intervertebral Disc - A Preliminary Study In Rabbits, Suhban Ra, Puvanan K, Murali Mr, Raghavendran Hb, Shani S, Abdullah Bj, Abbas Aa, Mohamad Ja, Kamarul T
Fluoroscopy Assisted Minimally Invasive Transplantation Of Allogenic Mesenchymal Stromal Cells Embedded In Hystemtm Reduce The Progression Nucleus Pulposus Degeneration In The Damaged Intervertebral Disc - A Preliminary Study In Rabbits, Suhban Ra, Puvanan K, Murali Mr, Raghavendran Hb, Shani S, Abdullah Bj, Abbas Aa, Mohamad Ja, Kamarul T
Murali Malliga Raman
This study was conducted to develop a technique for minimally invasive and accurate delivery of stem cells to augment nucleus pulposus (NP) in damaged intervertebral discs (IVD). IVD damage was created in noncontiguous discs at L4-L5 level; rabbits (N = 12) were randomly divided into three groups: group I treated with MSCs in HyStem hydrogel, group II treated with HyStem alone, and group III received no intervention. MSCs and hydrogel were administered to the damaged disc under guidance of fluoroscopy. Augmentation of NP was assessed through histological and MRI T2 mapping of the NP after eight weeks of transplantation. T2 …