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Full-Text Articles in Medicine and Health Sciences
Animal Models Of Rheumatoid Pain: Experimental Systems And Insights., Bradford D Fischer, Adeshina Adeyemo, Michael E O'Leary, Andrea Bottaro
Animal Models Of Rheumatoid Pain: Experimental Systems And Insights., Bradford D Fischer, Adeshina Adeyemo, Michael E O'Leary, Andrea Bottaro
Cooper Medical School of Rowan University Faculty Scholarship
Severe chronic pain is one of the hallmarks and most debilitating manifestations of inflammatory arthritis. It represents a significant problem in the clinical management of patients with common chronic inflammatory joint conditions such as rheumatoid arthritis, psoriatic arthritis and spondyloarthropathies. The functional links between peripheral inflammatory signals and the establishment of the neuroadaptive mechanisms acting in nociceptors and in the central nervous system in the establishment of chronic and neuropathic pain are still poorly understood, representing an area of intense study and translational priority. Several well-established inducible and spontaneous animal models are available to study the onset, progression and chronicization …
Irritable Bowel Syndrome: Clinical Manifestations, Dietary Influences, And Management., Ronald Ikechi, Bradford D Fischer, Joshua Desipio, Sangita Phadtare
Irritable Bowel Syndrome: Clinical Manifestations, Dietary Influences, And Management., Ronald Ikechi, Bradford D Fischer, Joshua Desipio, Sangita Phadtare
Cooper Medical School of Rowan University Faculty Scholarship
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is characterized by symptoms of chronic abdominal pain and altered bowel habits in the absence of an overtly identifiable cause. It is the most commonly diagnosed functional gastrointestinal disorder, accounting for about one third of gastroenterology visits. It generally presents as a complex of symptoms, including psychological dysfunction. Hypersensitivity to certain foods, especially foods that contain high amounts of fructose, plays a role in the pathophysiology of IBS. Elevated consumption of high-fructose corn syrup (HFCS) has been discussed in this aspect. The treatment options for IBS are challenging and varied. …