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Risk Thresholds For Alcohol Consumption: Combined Analysis Of Individual-Participant Data For 599 912 Current Drinkers In 83 Prospective Studies, Angela Wood, Carlos J. Crespo, Emerging Risk Factors Collaboration/Epic-Cvd/Uk Biobank Alcohol Study Group
Risk Thresholds For Alcohol Consumption: Combined Analysis Of Individual-Participant Data For 599 912 Current Drinkers In 83 Prospective Studies, Angela Wood, Carlos J. Crespo, Emerging Risk Factors Collaboration/Epic-Cvd/Uk Biobank Alcohol Study Group
OHSU-PSU School of Public Health Faculty Publications and Presentations
Background: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease.
Methods: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank). We characterised dose–response associations and calculated hazard ratios (HRs) per 100 g per week of alcohol (12·5 units per week) across 83 prospective studies, adjusting at least for study or centre, …