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Philadelphia College of Osteopathic Medicine

Theses/Dissertations

Major depressive disorder

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Full-Text Articles in Medicine and Health Sciences

Is Mindfulness-Based Cognitive Therapy Effective For Preventing Relapse Of Depression In Adults?, Katelynn S. O’Brien Jan 2020

Is Mindfulness-Based Cognitive Therapy Effective For Preventing Relapse Of Depression In Adults?, Katelynn S. O’Brien

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not mindfulness-based cognitive therapy is effective for preventing relapse of depression in adults.

Study Design: Review of three English-language randomized controlled trials published between 2014 and 2015.

Data Sources: Three randomized controlled trials published in peer-reviewed journals comparing mindfulness-based cognitive therapy to comparable treatment options found via PubMed.

Outcomes measured: Outcome measured was presence or absence of relapse of major depressive episodes in adults determined by the Structured Clinical Interview for DSM-IV.

Results: Kuyken et al. found that there was not a statistically significant difference in the …


What Are The Effects Of Curcumin, Whether Alone Or In Conjunction With Alternative Therapy, On Major Depressive Disorder?, Preeti Jain Jan 2018

What Are The Effects Of Curcumin, Whether Alone Or In Conjunction With Alternative Therapy, On Major Depressive Disorder?, Preeti Jain

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not curcumin, whether alone or in conjunction with alternative therapy, has an effect on Major Depressive Disorder (MDD).

Study Design: Systematic review of 3 primary studies, published between 2013 and 2016.

Data Sources: Three randomized control trials (RCT), two of which were double blind. These studies were found using Cochrane Systematic Reviews and PubMed.

Outcomes Measured: Outcome for all three articles are symptomatic changes of MDD. The outcomes measured were Patient-Oriented Evidence that Matters (POEMS) and were assessed using various self-rated tools.

Results: All three studies demonstrated …


Is Incidence Of Nausea Influenced By Brintellix In Patients Over The Age Of 18 With Major Depressive Disorder?, Juris Eyler Jan 2016

Is Incidence Of Nausea Influenced By Brintellix In Patients Over The Age Of 18 With Major Depressive Disorder?, Juris Eyler

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The Objective of this selective EBM review is to determine where or not, “Is Incidence of Nausea Influenced by Brintellix (Vortioxetine) in Patients over the Age of 18 with Major Depressive Disorder (MDD)?”

STUDY DESIGN: Review of three English language primary studies, published between 2011 and 2013

DATA SOUCES: Three double blind randomized controlled trials (RCTs). Sources were found on PubMed and Cochrane Library databases.

OUTCOMES MEASURED: To measure the incidence of nausea in patients over 18 who are diagnosed with major depressive disorder taking Brintellix compared to a placebo.

RESULTS: The randomized controlled studies results found that Brintellix …