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A Novel Method For Studying Cerebellar Responses To Tdcs Using Mice: An In Vitro Approach, Madison Cohen, Eashwar Mohan, Sagar Darira, Emily Graves, Huo Lu

Research Day

Cerebellar ataxias are a group of neurodegenerative disorders associated with impaired cerebellar circuitry leading to loss of motor coordination and balance. Recent studies using animal models have shown that transcranial direct stimulation (tDCS) could be an effective therapy for the treatment of cerebellar ataxia. The sole output of the cerebellar cortex is from the axons of Purkinje cells, which allows the cerebellum to influence motor behavior via the cerebello-thalamo-cortical pathway. However, the influence of tDCS on Purkinje cells remains unknown. In this study, we used a customized whole-cell patch-clamp chamber, which allowed for patch-clamp recordings from Purkinje cells during tDCS. …