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Full-Text Articles in Medicine and Health Sciences
Defying The Darkness: Countering Cancer With Light, Travis Hankins
Defying The Darkness: Countering Cancer With Light, Travis Hankins
Honors Theses
Triple-Negative Breast Cancer (TNBC) accounts for upwards of 15% of reported breast cancer cases. This subtype of breast cancer poses a greater threat to those diagnosed as compared to other types of breast cancer due to the lack of treatment options available. Additionally, TNBC grows and spreads faster, tends to be more aggressive, and has a greater chance of recurrence than its counterparts. Altogether, TNBC cases generally have a worse prognosis over other types of breast cancer. Photodynamic therapy (PDT) is currently being researched as a way to treat TNBC. Photodynamic therapy agents are light-activated materials used for localized disease …
Carrier-Free Chemo-Ptt/Pdt Ionic Nanomaterials For Combination Cancer Therapy, Samantha Macchi
Carrier-Free Chemo-Ptt/Pdt Ionic Nanomaterials For Combination Cancer Therapy, Samantha Macchi
Arkansas Women in STEM Conference
Herein, we describe a carrier-free combination nanodrug for treatment of cancer. In this work, we combined a photothermal compound and a chemotherapeutic drug using ionic liquid chemistry. We utilized a facile, one-step metathesis approach to replace the counter cation of a near infra-red (NIR) dye (photothermal agent) with a chemotherapeutic cation to synthesize an ionic material-based combination cancer therapy drug to deliver multiple mechanisms simultaneously. The nanodrugs were developed by using a reprecipitation method. The detailed photophysical properties of this new combination therapy molecule was investigated in ethanol solution as well as in nanoparticles forms in aqueous media. The singlet …