Medicine and Health Sciences Commons^™

The Efficacy Of Emdr: A Meta-Analysis Of Emdr As Clinical Treatment, Allison Smith

Honors Theses

Eye movement desensitization and reprocessing (EMDR) is a controversial clinical treatment most often used in the treatment of anxiety and depressive disorders. Many clinicians use this therapy, but no consensus exists whether this treatment works. This meta-analytic review examined EMDR versus waitlist or alternative treatments, in adult and child populations, and in reduction of depression and anxiety symptoms. Results indicate that EMDR has no significant effect in the reduction of symptoms in either population for either psychological disorder. Implications for further research are discussed.

Thrilling Monotony: A Summer Of Alzheimer's Research, Baronger Dowell Bieger

Honors Theses

The primary genetic risk determinant for late-onset Alzheimer's disease is the apolipoprotein E gene (APOE). Variations in this gene produce three different isoforms of the apolipoprotein E protein (ApoE): ApoE2, ApoE3, and ApoE4. ApoE# is the most common isoform, so rates of LOAD among other genotypes are indexed to this variant. ApoE2 is rather rare, but its carriers are less likely to get LOAD; when they do, they get it later. The second most common variant is ApoE4, and its carriers are significantly more likely to get LOAD. They also tend to succumb earlier. Once developed, LOAD is characterized by …

Acute Promyelocytic Leukemia As A Possible Source For Ajulemic Acid Binding, Brian Christopher Monk

Honors Theses

Acute promyelocytic leukemia (APL) is a cancer that affects bone marrow, the blood-forming tissue (of the body). This type of leukemia accounts for approximately 10% of acute myeloid leukemia (AML) cases. Normally this cancer is treated with a drug called all-trans retinoic acid (ATRA), but other variations of treatment do exist. The importance of this research is that APL cells express contains a receptor, retinoic acid receptor-a (RARa), which ajulemic acid (AJA) may bind to in order to induce apoptosis in Ewing sarcoma (ES), a pediatric bone cancer. Therefore, this research will focus on the ability of AJA to induce …

The Effect Of Cannabinoids On Triple Negative Breast Cancer Cells, Haley Dahl

Honors Theses

Triple Negative Breast Cancer (TNBC) is a difficult type of cancer to treat because it is negative for progesterone, estrogen, and HER-2 receptors. Because TNBC is negative for these three receptors, it does not respond to normal hormonal therapies. The purpose of my experiment is to see if different cannabinoids, compounds from the cannabis plants, could be used as alternative treatment options. These experiments employed three different cannabinoids: ajulemic acid, cannabidiol, and hemp oil. Cell viability was measured after 72 hours of treatment using a MTT assay. The results showed that the three cannabinoids could be used to effectively destroy …

Ten Weeks With Green Beans...And Then Some: Determination Of Bisphenol-A (Bpa) In Canned Goods From Arkansas Markets Using Fluorescence Spectrophotometry, Rachel Pruett

Honors Theses

Bisphenol A (BPA) is a chemical widely used in production of consumer goods. It has come under scrutiny recently after being labeled as an endocrine disruptor (ED), mostly causing adverse effects in infants and young children. It has been associated with diabetes, cardiovascular disease, and abnormal maturation. Because it is so commonly used in product development, humans are exposed to BPA through various means, such as ingestion or dermal absorption. It is a concern that the combined exposure could cause serious effects even in small doses.

In canned foods, the chemical is made into an epoxy resin to provide a …

Handedness: Does It Matter?, Jessie Little

Honors Theses

Pharmaceutical drugs are activated through a process called xenobiotic metabolism. Out of the drugs on the market, 50% are chiral, having two enantiomers. When this drug is metabolized, one of the enantiomers is typically preferred over the other. This unique specificity is thought to be a result of the structure of the protein. Interactions between different residues and the drug being metabolized may affect the movement and orientation of the drug as it moves down the channel of the protein to be oxidized. Further understanding of the metabolism of chiral drugs could possibly be used to predict how new drugs …

Beauty Is Born Of The Rain: Walter Inglis Anderson's Art And Isolation, Chloe Evelyn Huff

Honors Theses

Walter “Bob” Inglis Anderson: naturist, painter, and ceramicist. Some say he was mad, while others were inclined to say that he was merely passionate regarding nature and his watercolors. However, he is highly regarded as one of the most talented artists east of the Mississippi. In the following pages, his life, art, and battles with a mental illness will be spread out and investigated closely with the primary goal of observing whether his bouts of illness affected his art. To investigate this relationship, it is necessary to examine Walter Anderson’s early life and art, along with his progression into mental …

Interaction Of Disease, Drugs, And Disposition In Ewing's Sarcoma Patients, Madeline Martin

Honors Theses

Ewing's Sarcoma is a pediatric bone cancer that is highly aggressive, leading to a five year survival rate of not only 30% even with multi-modal treatment protocols. Improved therapeutic options are desperately needed. Our research has focused on the ability of the psychoactive cannabinoid, ajulemic acid, to induce apoptosis and decrease metastatic potential in cells from members of the Ewing Sarcoma family of tumors. Recently, we explored the effects of the naturally-occuring cannabinoid, cannabidiol, on three-dimensional spheroids that mimic the cellular components and microenvironment of Ewing's tumors. We looked at how this treatment affects VEGF, a mediator of angiogenesis, to …

Bringing Bpa To Light: Determination Of Bisphenol A In Thermal Receipt Paper Water Samples And Lake Water Samples Using Fluorescence Spectrophotometry, Bailey Chitwood

Honors Theses

Bisphenol A (BPA) is a chemical that is commonly used in harder plastic products, in the lining of food cans, and in thermal receipt paper. The usage of BPA in common products has become a concern for humans, especially for infants and young children, because of its effects as an endocrine disrupter. BPA has been linked to diabetes, cardiovascular disease, obesity, and certain developmental disorders. Because of the possible effects of BPA on the development of infants and young children, the use of BPA in baby bottles and other baby products has been outlawed. However, BPA is still used in …