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Acute Promyelocytic Leukemia As A Possible Source For Ajulemic Acid Binding, Brian Christopher Monk
Acute Promyelocytic Leukemia As A Possible Source For Ajulemic Acid Binding, Brian Christopher Monk
Honors Theses
Acute promyelocytic leukemia (APL) is a cancer that affects bone marrow, the blood-forming tissue (of the body). This type of leukemia accounts for approximately 10% of acute myeloid leukemia (AML) cases. Normally this cancer is treated with a drug called all-trans retinoic acid (ATRA), but other variations of treatment do exist. The importance of this research is that APL cells express contains a receptor, retinoic acid receptor-a (RARa), which ajulemic acid (AJA) may bind to in order to induce apoptosis in Ewing sarcoma (ES), a pediatric bone cancer. Therefore, this research will focus on the ability of AJA to induce …