Medicine and Health Sciences Commons^™

Bactericidal Effects Of Low Temperature Atmospheric Pressure Plasma On Porphyromonas Gingivalis, Arwa Mahasneh

Dental Hygiene Theses & Dissertations

Purpose: The biomedical application of low temperature atmospheric pressure plasma (LTAPP) is a collaborative interest for engineering, medical, dental and biological researchers. This laboratory study tested whether LTAPP can limit growth of Porphyromonas gingivalis, a periodontal pathogen strongly associated with periodontal disease, disease progression, and refractory periodontitis. Methods: After extensive pilot trials, the study consisted of 24 agar plate samples of P. gingivalis- 20 samples were exposed to LTAPP at 5, 7, 9 and 10 minutes and 4 control samples were exposed to helium gas only. Immediately after exposures, the samples were incubated anaerobically for 72 hour at …

The Role Of Human Endogenous Retroviruses In Renal Cell Carcinoma, Michele D. Tisdale

Biological Sciences Theses & Dissertations

Human endogenous retroviruses make up approximately 8-9% of the human genome. A number of expressed HERVs, those that are actively transcribing, have been associated with various cancers. Suppression mechanisms that control HERV expression often fail or become more permissive in tissues where expression should be restricted. Previous studies have identified HERV expression in breast cancer tissues, whereas normal tissue HERV expression remained suppressed. In addition, studies of DNA hypermethylation have correlated with the ability to contribute to cancer development. Hypermethylation of several tumor suppressor genes occurs frequently in cancers and alterations in promoter regions could contribute to the development of …

Effects Of Low-Temperature Atmospheric Pressure Plasma On Streptococcus Mutans, Margaret Farrer Lemaster

Dental Hygiene Theses & Dissertations

The recent emergence of low temperature atmospheric pressure plasma (LTAPP) technology has led researchers to explore biomedical applications. The present study set out to determine if LTAPP has the ability to inactivate dental caries causing bacteria, specifically Streptococcus mutans. Methods: A total of 90 samples were processed. Seventy-two samples of S. mutans at 1: 100 dilution in BHI broth were exposed to LTAPP for various time intervals (60, 120, 180, 300 seconds). Eighteen control samples were plated but not exposed to LTAPP. Samples were plated on Mi tis salivarius (MS) agar and incubated 48 hours at 37° C. Colony …

Inhibition Of Yeast Hexokinase By The Antimalarial Drug Artemisinin: Probing Mechanism Of Action With A Model Enzyme, Jennifer S. Spence

Biological Sciences Theses & Dissertations

A leading infectious cause of death, malaria threatens approximately half of the world's population, and drug-resistant strains of Plasmodium falciparum have created immense difficulty in chemotherapy of the disease. The artemisinin (ART) class of antimalarials may represent a powerful solution. In addition to their safety, effectiveness, and moderate cost, they are the only drugs in use for which there has been no widespread evidence of clinical resistance. The exact parasiticidal mechanism of ART is highly contested, but evidence suggests that protein alkylation may play a role in cytotoxicity. in vitro essays were performed using yeast hexokinase (HK) to demonstrate a …

Immediate Effect Of Heel-Pain Orthosis And An Augmented Low-Dye Taping On Plantar Pressures And Pain In Subjects With Plantar Fasciitis, Tracy Andus

Human Movement Sciences & Special Education Theses & Dissertations

Research has been done investigating plantar pressures and pain in subjects with pathologies after the application of orthoses and arch taping. To date, however, no study has been conducted investigating plantar pressures and pain in subjects with plantar fasciitis after the application of the augmented low-dye taping (ALD) in comparison to a heel-pain orthosis (HPO). Therefore, the purpose of this study was to determine the effects of the ALD in comparison to a HPO on pain, peak plantar pressure (PPP), and mean plantar pressure (MPP) under multiple areas of the foot in subjects with plantar fasciitis while walking and jogging. …

The Effects Of Isolated Hamstring Fatigue On Jump Landing In Healthy Recreational Athletes, Kristen Anne Phillips

Human Movement Sciences & Special Education Theses & Dissertations

The musculature of the lower extremity provides dynamic stability during daily and athletic tasks. In landing tasks, the lower extremity absorbs forces and reduces excessive stresses and motions that are placed upon the body. Neuromuscular fatigue has been linked to an increase in injury and altered kinematics during jump landing tasks. The purpose of this study was to analyze the effects of hamstring fatigue on knee and hip kinematics pre and post hamstrings fatigue while landing from a box drop of 30cm height, during the stop-jump phase. The study aimed to quantify the kinematic data of the hip and knee …

Mechanisms Of Regulation Of Proximal Tubule Sodium Transporters In Obesity-Induced Hypertension, Marta A. Ambrozewicz

Theses and Dissertations in Biomedical Sciences

Hypertension is one of the common complications of obesity. Using a rat model of diet induced obesity and hypertension we investigated some of the mechanisms that are involved in regulation of blood pressure in obesity. The first aim of this study was to determine the role of proximal tubule transporters on the renal sodium handling in obese hypertensive (OP) and lean normotensive (OR) rats. An acute increase in renal perfusion pressure resulted in a blunted natriuretic response in OP vs. OR rats and indicated that increased sodium reabsorption in the proximal tubule is casual, at least in part, for hypertension …

Reflective Visual Journaling During Art Therapy And Counseling Internships, Sarah P. Deaver

Counseling & Human Services Theses & Dissertations

Visual journaling is thought to promote students' critical reflection upon their previous learning, their current experiences, and their ongoing professional growth. Research supports the value of written journals as educational tools that encourage reflection, but the potential for visual journaling to facilitate reflection has not been explored through systematic inquiry until now.

This qualitative multiple case study explored four art therapy students' and four counseling students' responses to visual journaling during their internships. They maintained their journals throughout one 15-week academic semester, and were interviewed four times over the course of the study. Data consisted of transcribed interviews and photographs …

Oral Healthcare In Kenya: Implications For Dental Hygiene Care, Grace Kogi

Dental Hygiene Master's Papers and Projects

This paper is a review of literature describing the educational, healthcare delivery and healthcare finance systems in Kenya. The document discusses the unmet oral health needs of the Kenyan population and how implementing the role of the dental hygienist would positively impact oral health promotion throughout the country. Kenyan communities experience all of the major environmental determinants of oral disease, e.g., widespread poverty, underdevelopment, outdated dental equipment, insufficient supply and distribution of qualified dental care professionals and lack of preventive oral health services. About six in ten Kenyans are unable to afford healthcare, clothing, or food; therefore, oral healthcare has …

Test Of A Multidisciplinary Health Behavior Model Of Medicare Elders' Antihypertensive Acquisitions, Ann Marie Kopitzke

Health Services Research Dissertations

This study examined the relative utility of the enhanced Health Belief Model as compared to the proposed Pharmaceutical Acquisition Model for Medicare Elders (PAMME) in describing antihypertensive acquisition with usage intentions for Medicare elders (65 years or older) in Southeastern Virginia. Data collection included record reviews to identify hypertensive Medicare elders. Consenting Medicare elders were randomly selected for invitation, with consenting Medicare elders contacted by telephone or in-person interviews. The survey instrument utilized open and closed ended questions. The target population for this study is Southeastern Virginia Medicare elders enrolled in a Part D plan and prescribed at least one …

Traumatic Stress As A Predictor Of Suicidality, Sherry Malana Todd

Counseling & Human Services Theses & Dissertations

Suicide is a deliberate act of annihilation against one's self due to a crisis of problem solving. Far too many youth are dying by their own hands resulting in suicide being the third leading cause of death for 10-19 year olds (CDC, 2005). Suicide is particularly problematic for adolescents due to the impulsivity inherent in adolescent development. Since 1980, the national suicide rate of African American youth has increased by 114 percent (CDC). Suicidality has been positively correlated with depression and posttraumatic stress disorder (PTSD; Kessler et al., 1999). Suicidality is more prevalent when a person experiences a tragic or …