Medicine and Health Sciences Commons^™

The Synthesis And Evaluation Of The Cardiovascular Activity Of Novel Imidazole Ring Systems, Joseph E. De Los Angeles

Chemistry & Biochemistry Theses & Dissertations

An investigation was undertaken to synthesize and evaluate the cardiovascular activity of two imidazole ring systems. Imidazoles with hypotensive activity would provide novel potential antihypertensive drugs. These novel structures may also find use as chemical probes in the study of the cardiovascular system and as prototypes for other potential cardiovascular agents.

The histamine derivative, 7,7-dipyridyl-4,5,6,7-tetrahydroimidazo-[4,5-c]pyridine (ligand l), was demonstrated to possess significant hypotensive activity in laboratory rats. A 15 mg/Kg dose of ligand 1 produces a statistically significant decrease in blood pressure when injected IP. This hypotensive effect is also associated with marked increase in heart rate. Although compound 1 …

A Comparative Analysis Of Head Nurse Role Perceptions In Acute Care Hospitals, Margaret A. Miller

Nursing Theses & Dissertations

This study examined the perceptions of 43 head nurse participants from private, voluntary and government hospital settings. Utilizing a tool adapted by the researcher, the Head Nurse Role Questionnaire (HNRQ), the study sought to explore five areas of job context: Job Variability, Job Expertise, Job Definition, Job Capacity and Job Incentives. Differences in perceptions were analyzed utilizing descriptive statistics and Analyses of Variance. The three organizational dimensions of this study included: standardization, formalization and organizational culture. Findings revealed significant differences in Job Definition. Descriptive statistical results indicated differences in hospital settings. Qualitative analyses displayed three categories of head nurse attributes …

Use Of Two Data Collection Strategies To Evaluate Stressors And Coping In Spouses Of Patients Sustaining A Myocardial Infarction, Pamalla Manz Stockho

Nursing Theses & Dissertations

This study compared stressors and coping mechanisms identified by spouses of myocardial infarction (MI) patients in a close-ended, self-administered questionnaire (SAS) and an open-ended, nurse-administered questionnaire (NAS). Twenty female participants were divided into two groups and completed the NAS, SAS, and demographic information. The purpose of dividing the group was to explore possible experimenter effect. One group was administered the NAS preceding the SAS. The second group completed the SAS preceding the NAS. Qualitative analysis revealed equivalent stressors and coping mechanisms identified by the NAS and SAS. Stressors related to the MI decreased over time for spouses whose husbands made …

The Image Of The Nurse In A Professional Journal: A Historical Perspective, Dawn Louise Crane

Nursing Theses & Dissertations

Authors of journal articles contribute to the image of the nurse that is projected to journal readers. The purpose of this study was to explore the image of nursing as portrayed in articles published in Nursing Outlook from 1960-1979. A descriptive study, with content analysis, was conducted using articles concerned with professionalism or nursing education published in Nursing Outlook from 1960-1979 (a time identified as negative for societal images of nursing). The educational background of the authors was noted. Findings indicated that the majority of authors projected the image of a nurse as a well-educated, independent professional; images not reflective …

Effectiveness Of A Hydrogen Peroxide, Sodium Chloride, Sodium Bicarbonate Dentifrice Upon Microbiota Associated With Periodontitis, Jill M. Modi

Dental Hygiene Theses & Dissertations

The purpose of this study was to investigate the effectiveness of a hydrogen peroxide, sodium chloride, sodium bicarbonate dentifrice upon quantitative changes in the sulcular microbial species Bacteroides melaninogenicus and in the gingival condition and plaque accumulation associated with periodontitis. Fifteen subjects from the Hampton Veteran's Administration Medical Center w e r e selected according to a standard criteria. Split mouth experimental design was used. One arch of each patient was assigned randomly to periodontal instrumentation. Half the mouth then was assigned randomly an experimental or a control dentifrice to be utilized once daily. culture analysis, the Gingival Index and …

Determination Of Human Sperm Cell Acrosin Activity From Normal And Subfertile Men, Dilrowshan H. Haque

Chemistry & Biochemistry Theses & Dissertations

Acrosin is an acrosomal enzyme which is reported to be involved in sperm penetration through cumulus, zona, and ooplasma. This enzyme has been reported to be significantly lower in sperm of infertile men compared to sperm of fertile men. The acrosin assay which has been developed can be used for studies in patients with suspected infertility and may be used on a fraction of most semen specimens being evaluated in a clinical andrology laboratory.

Within-run precision studies yielded coefficients of variation of 11% for a low-activity pool and 9% for normalactivity pool specimens. Between-run precision studies using a single donor …

Effects Of Air Polishing And Rubber Cup Polishing On Enamel Abrasion, April Kee

Dental Hygiene Theses & Dissertations

An investigation was conducted to determine if statistically significant differences in enamel abrasion occurred when molar specimens were air polished (AP) and rubber cup polished (RCP). Thirty human molars were randomly divided into two groups. Molar buccal surfaces were masked longitudinally to provide control surfaces. Each polishing technique was applied for two minutes and thirty seconds on fifteen exposed enamel surfaces. Buccal enamel surfaces were divided into coronal and cervical sections for microscopic review. Six enamel thickness measurements were determined for each coronal and cervical enamel section using the scanning electron microscope. Measurements of AP and RCP coronal and cervical …

Factors That Influence Prepared Childbirth Couples' Use Of Epidural Anesthesia For Labor And Delivery, Terri S. Chambers

Community & Environmental Health Theses & Dissertations

The purpose of this study was to identify factors that influence a Prepared Childbirth couple's decision to utilize epidural anesthesia for labor and delivery. Review of the literature indicated a high correlation between epidural use for uncomplicated labors and deliveries and a high incidence of maternal complications and low neonatal neurological and behavioral scores.

A sample of twenty-nine couples was used in this prospective, non-experimental field study for the research. Data were collected utilizing two developed demographic and factual event tools, Rotter's Internal-External Locus of Control Tool and Spanier's Dyadic Marital Adjustment Tool.

Three hypotheses were developed and data were …

Preferred Provider Organizations: Developmental Indicators, Marcia Anne Guida

Community & Environmental Health Theses & Dissertations

The purpose of this research was to determine what factors, if any, led to the development of a preferred provider organization and if these factors were related to sponsorship. A survey instrument was developed and mailed to a random sampling of 90 existing preferred provider organizations' executive directors for their completion. A Two-Factor Contingency Table Analysis was compiled. Chi-square, and the Contingency factor, C, were computed and tested at the .05 level of significance. First and second preference analyses were done on the responses to developmental indicators. Mean percentages were tallied for: sponsorship, tax status, alternative delivery systems in the …

Pregravid Weight, Prenatal Weight Gain And Maternal Age As Risk Factors In Pregnancy-Induced Hypertension Development, Maryellen C. Remich

Nursing Theses & Dissertations

This study examined whether the factors of pregravid weight, total prenatal weight gain at twenty-eight weeks and maternal age correlated with the development of pregnancy-induced hypertension in the third trimester. An ex post facto chart review of low risk primigravidas attending a public health maternity clinic was performed. A multiple regression correlation procedure demonstrated no significant correlation between the variables. Significant results of Chi-sguare tests of independence were demonstrated between low maternal age and pregnancy-induced hypertension development and between the failure of the mean arterial pressure to decrease in the second trimester and the development of pregnancy-induced hypertension in the …

The Effects Of Luteinizing Hormone And Adenosine 3',5'-Cyclic Monophosphate On Phospholipid Metabolism By Luteal Mitochondria, Jim John Sadighian

Chemistry & Biochemistry Theses & Dissertations

Luteinizing hormone (LH) increases intracellular concentrations of adenosine 3', 5 '-cyclic monophosphate and the phosphoinositides, phosphatidylinositol (PI), PI 4'-phosphate (PIP) and PI 4' .5 1 - bispbosphate (PIP₂). It is believed that cAMP and the phosphoinositides act concertedly to regulate mitochondrial conversion of cholesterol to pregnenolone. This study examined the effects of LH and N⁶ ,O² -dibutyryl cAMP (dbcAMP) on phospholipids metabolism by luteal mitochondria and the influence of dbcAMP and the phosphoinosi tides on mitochondrial steroid production. Mitochondria were isolated from unincubated and incubated luteal tissue by differential centrifugation. Phospholipids were extracted from the mitochondria …

Clinical Effectiveness Of ListerineR And ViadentR Mouthrinses On Bacterial Plaque And Gingivitis, Debra Pizzola Powell

Dental Hygiene Theses & Dissertations

The purpose of this investigation was to determine the effects of two commercial mouth rinses, Listerine^R and Viadent^R, on bacterial plaque and gingivitis. over a sixweek period, 24 adults, ages 18-41, were examined for the amount of bacterial plaque and level of gingivitis using Silness and toe's Plaque Index (PLI) and Gingival Index (GI). At the beginning of each two week period, subjects were examined for the amount of plaque and level of gingivitis and given a different mouthrinse: appointment one--viadent^R (mouthrinse A), appointment two--placebo mouthrinse (mouthrinse B), and appointment three--Listerine^R (mouthrinse C). Additionally, subjects …