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Full-Text Articles in Medicine and Health Sciences

Atomic Force Microscopy Characterization Of Collagen ‘Nanostraws’ In Human Costal Cartilage, Michael W. Stacey, Diganta Dutta, Anthony Asmar, H. Elsayed-Ali, R. Kelly Jr., A. Beskok Jan 2013

Atomic Force Microscopy Characterization Of Collagen ‘Nanostraws’ In Human Costal Cartilage, Michael W. Stacey, Diganta Dutta, Anthony Asmar, H. Elsayed-Ali, R. Kelly Jr., A. Beskok

Bioelectrics Publications

Costal cartilage, a type of hyaline cartilage that bridges the bony ribs and sternum, is relatively understudied compared to the load bearing cartilages. Deformities of costal cartilage can result in deformation of the chest wall, where the sternum is largely pushed toward or away from the spine, pectus excavatum and pectus carinatum, respectively, with each condition having significant clinical impact. In the absence of extensive literature describing morphological features of costal cartilage, we characterized a sample from the costal margin immunohistologically and through atomic force microscopy. We had previously observed the presence of collagen ‘nanostraws’ running the length of costal …


Comparing Responsiveness Of Six Common Patient-Reported Outcomes To Changes Following Autologous Chondrocyte Implantation: A Systematic Review And Meta-Analysis Of Prospective Studies, Jennifer S. Howard, Christian Lattermann, Johanna M. Hoch, Carl G. Mattacola, Jennifer M. Medina Mckeon Jan 2013

Comparing Responsiveness Of Six Common Patient-Reported Outcomes To Changes Following Autologous Chondrocyte Implantation: A Systematic Review And Meta-Analysis Of Prospective Studies, Jennifer S. Howard, Christian Lattermann, Johanna M. Hoch, Carl G. Mattacola, Jennifer M. Medina Mckeon

Rehabilitation Sciences Faculty Publications

Objective: To compare the responsiveness of six common patient-reported outcomes (PROs) following autologous chondrocyte implantation (ACI). Design: A systematic search was conducted to identify reports of PROs following ACI. Study quality was evaluated using the modified Coleman Methodology Score (mCMS). For each outcome score, pre- to postoperative paired Hedge's g effect sizes were calculated with 95% confidence intervals (CIs). Random effects meta-analyses were performed to provide a summary response for each PRO at time points (TP) I (<1 year), II (1 year to <2 years), III (2 years to <4 years), IV (>= 4 years), and overall. Results: The mean mCMS for the 42 articles included was 50.9 +/- 9.2. For all evaluated instruments, …