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Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Electrically Mediated Plasmid Dna Delivery To Hepatocellular Carcinomas In Vivo, L. Heller, M. J. Jaroszeski, D. Coppola, C. Pottinger, R. Gilbert, Richard Heller
Electrically Mediated Plasmid Dna Delivery To Hepatocellular Carcinomas In Vivo, L. Heller, M. J. Jaroszeski, D. Coppola, C. Pottinger, R. Gilbert, Richard Heller
Bioelectrics Publications
Gene therapy by direct delivery of plasmid DNA has several advantages over viral gene transfer, but plasmid delivery is less efficient. In vivo electroporation has been used to enhance delivery of chemotherapeutic agents to tumors in both animal and human studies. Recently, this delivery technique has been extended to large molecules such as plasmid DNA. Here, the successful delivery of plasmids encoding reporter genes to rat hepatocellular carcinomas by in vivo electroporation is demonstrated.
Comparison Of Neonatal Nurse Practitioners' And Pediatric Residents' Care Of Extremely Low-Birth-Weight Infants, M. Gary Karlowicz, Jennifer L. Mcmurray
Comparison Of Neonatal Nurse Practitioners' And Pediatric Residents' Care Of Extremely Low-Birth-Weight Infants, M. Gary Karlowicz, Jennifer L. Mcmurray
Nursing Faculty Publications
Objective: To compare outcomes and charges of health care delivery to extremely low-birth-weight infants by neonatal nurse practitioners (NNP) and pediatric residents.
Design: Retrospective cohort study.
Setting: A 56-bed neonatal intensive care unit (NICU) in a university teaching hospital.
Methods: Study population included all infants with birth weights less than 1000 g who were admitted to the NICU during the 2-year period between September 1, 1994, and August 31, 1996. Infants who died earlier than 12 hours of age, or who were admitted after 1 week of age or with major malformations, chromosomal abnormalities, or congenital infections were excluded. There …
Identification Of Violence In The Home - Pediatric And Parental Reports, Bonnie D. Kerker, Sarah Mccue Horwitz, John M. Leventhal, Stacey Plichta, Phillip J. Leaf
Identification Of Violence In The Home - Pediatric And Parental Reports, Bonnie D. Kerker, Sarah Mccue Horwitz, John M. Leventhal, Stacey Plichta, Phillip J. Leaf
Community & Environmental Health Faculty Publications
Objectives: To compare the rates of domestic violence reported by mothers with those identified by physicians, to compare the rates of harsh discipline practices reported by mothers with the rates of abuse identified by physicians, and to examine the relationship between reported domestic violence and harsh discipline practices.
Design: Interviews with parents and pediatricians to compare pediatric detection of domestic violence and child abuse with parental reports of domestic violence and harsh discipline practices.
Setting: Community-based pediatric practices in the 13-town greater New Haven, Conn, area.
Participants: Of the 23 practices invited, 19 agreed to participate. Of the 2006 parents …
Applications Of Wavelet Transforms In Biomedical Optoacoustics, Zibiao Wei, Shujun Yang, Amin N. Dharamsi, Barbara Hargrave
Applications Of Wavelet Transforms In Biomedical Optoacoustics, Zibiao Wei, Shujun Yang, Amin N. Dharamsi, Barbara Hargrave
Biological Sciences Faculty Publications
We discuss the utility of wavelet transform methods in signal processing in general, and in particular, demonstrate the technique in optoacoustic applications. In several optoacoustic experiments with different samples, we have successfully enhanced the signal to noise ratios. Wavelet transforms optimize resolution by utilizing a tailored, variable time-window in different frequency regions. The technique's great advantage lies in the fact that the wavelet transform adds some redundancy to the original signal, and some desired features can be enhanced in the transformed space. In addition, proper choice of the basis set allows a sparse representation of the signal. Therefore, even when …