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Full-Text Articles in Medicine and Health Sciences
Race, Ethnicity, Psychosocial Factors, And Telomere Length In A Multicenter Setting, Shannon M. Lynch, M. K. Peek, Nandita Mitra, Krithika Ravichandran, Charles Branas, Elaine Spangler, Wenting Zhou, Electra D. Paskett, Sarah Gehlert, Cecilia Degraffinreid, Timothy R. Rebbeck, Harold Riethman
Race, Ethnicity, Psychosocial Factors, And Telomere Length In A Multicenter Setting, Shannon M. Lynch, M. K. Peek, Nandita Mitra, Krithika Ravichandran, Charles Branas, Elaine Spangler, Wenting Zhou, Electra D. Paskett, Sarah Gehlert, Cecilia Degraffinreid, Timothy R. Rebbeck, Harold Riethman
Medical Diagnostics & Translational Sciences Faculty Publications
Background
Leukocyte telomere length(LTL) has been associated with age, self-reported race/ethnicity, gender, education, and psychosocial factors, including perceived stress, and depression. However, inconsistencies in associations of LTL with disease and other phenotypes exist across studies. Population characteristics, including race/ethnicity, laboratory methods, and statistical approaches in LTL have not been comprehensively studied and could explain inconsistent LTL associations.
Methods
LTL was measured using Southern Blot in 1510 participants from a multi-ethnic, multi-center study combining data from 3 centers with different population characteristics and laboratory processing methods. Main associations between LTL and psychosocial factors and LTL and race/ethnicity were evaluated and then …