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Northern Michigan University

All NMU Master's Theses

Depression

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Concussion And Mental Health: Case Series, Haley M. Clark Aug 2022

Concussion And Mental Health: Case Series, Haley M. Clark

All NMU Master's Theses

Concussion is the most common traumatic brain injury in the United States, and is thought to lead to adverse effects on mental health. No studies to date have examined mental health throughout concussion recovery. This project examined the effect of concussion on three aspects of mental health: anxiety (Hamilton Anxiety Rating Scale), depression (Beck’s Depression Inventory), and aggression, (Buss-Perry Aggression Questionnaire) at three time points (baseline, mid-season, and postseason) and if the athlete had a concussion, they completed the questionnaire once upon diagnosis, bi-weekly until return-to-play, and bi-weekly for two weeks after being cleared for participation. Each concussion showed an …


Antidepressant Effects Of The Nts1 Agonist Pd149163 In The Forced Swim Test, Lawrence Carey Iv Aug 2014

Antidepressant Effects Of The Nts1 Agonist Pd149163 In The Forced Swim Test, Lawrence Carey Iv

All NMU Master's Theses

Neurotensin is a neuropeptide that influences monoaminergic neurotransmission in areas of the brain involved in the pathophysiology of depression. The forced swim test is a commonly used screening model for putative antidepressant medications. Drugs that have antidepressant effects in humans reliably decrease the time animals spend in an immobile posture in the forced swim test without increasing general locomotor activity as measured in an open field test. The present study sought to examine the effects of the neurotensin NTS1 receptor agonist PD149163 and the tricyclic antidepressant drug imipramine on immobility in the forced swim test and on locomotor activity …